CSD170301: An Unblinded, Parallel, Randomized Study to Assess Nicotine Uptake in Smokers From Four Different Electronic Cigarettes

Inclusion Criteria:

1. Able to read, understand, and willing to sign an Informed Consent Form (ICF) and complete questionnaires written in English.
2. Generally healthy males and females, 21 to 60 years of age, inclusive, at Screening Visit.

3. Subjects must meet one (a or b) of the following tobacco use conditions:

   1. Exclusive cigarette smoker who self-reports smoking at least (≥) 10 cigarettes per day for at least 6 months prior to Screening Visit. Brief periods of abstinence more than 30 days prior to Screening due to illness, quit attempt or clinical study participation will be allowed at the discretion of the Investigator.
   2. Dual user of combustible cigarettes and ECs who self-reports: 1. Smoking at least (≥) 10 cigarettes per day for at least 6 months prior to Screening Visit. Brief periods of abstinence more than 30 days prior to Screening due to illness, quit attempt or clinical study participation will be allowed at the discretion of the Investigator and 2. Using a nicotine-containing cig-a-like EC or a tank system EC either daily or at least weekly for at least 3 months prior to Screening Visit.
4. Willing to be confined overnight and abstain from tobacco- and nicotine- containing product use for 12 hours prior to IP use through Study Discharge.
5. Willing to use assigned IP during the study according to protocol.
6. Expired breath carbon monoxide (ECO) level is ≥10 parts per million (ppm) at the Screening Visit and Study Day 1.
7. Positive urine cotinine test at the Screening Visit and Study Day 1.
8. No intent to quit smoking or vaping from Screening to Study Day 2.
9. Females of childbearing age must be willing to use a form of contraception acceptable to the Investigator from the time of signing informed consent until Study Discharge, or be surgically sterile for at least 90 days prior to the Screening Visit.

Exclusion Criteria:

1. Presence of clinically significant or unstable/uncontrolled acute or chronic medical conditions at the Screening Visit, as determined by the Investigator, that would preclude a subject from participating safely in the study (e.g., uncontrolled hypertension, diabetes, asthma or other lung disease, cardiac disease, neurological disease or psychiatric disorders) based on safety assessments such as clinical laboratory tests, pregnancy tests, medical history, and physical/oral examinations.
2. At risk for heart disease, as determined by the Investigator.
3. Systolic blood pressure of ≥150 mmHg or a diastolic blood pressure of ≥ 95 mmHg, measured after being seated for 5 minutes.
4. Weight of ≤ 110 pounds.
5. Poor peripheral venous access.
6. Use of medicine for treatment of depression or asthma (e.g., paroxetine [Paxil®], montelukast [Singulair®], albuterol [Proventil® HFA]), as deemed clinically significant by the Investigator.
7. Use of any medication or substance that aids in smoking cessation, including but not limited to any nicotine replacement therapy (NRT) (e.g., nicotine gum, lozenge, patch), varenicline (Chantix®), bupropion (Wellbutrin®, Zyban®), or lobelia extract within 30 days prior to the Screening Visit.
8. History or presence of hemophilia or other bleeding disorders.
9. History or presence of clotting disorders with concomitant use of anticoagulants (e.g., clopidogrel [Plavix®], warfarin [Coumadin®, Jantoven®] and aspirin [> 325 mg/day]).
10. Participation in another clinical trial within (≤) 30 days prior to the time of consent. The 30-day window for each subject will be derived from the date of the last study event in the previous study to the time of consent of the current study.
11. Positive test for human immunodeficiency virus (HIV), Hepatitis B surface antigen (HBsAg), or Hepatitis C virus antibody (anti-HCV).
12. Females who have a positive pregnancy test, are pregnant, breastfeeding, or intend to become pregnant during the course of the study.
13. Females ≥ 35 years of age currently using systemic, estrogen-containing contraception or hormone replacement therapy.
14. A positive urine drug screen without disclosure of corresponding concomitant medication(s) at the Screening Visit or on Study Day 1.
15. A positive alcohol breathalyzer result at Screening Visit or on Study Day 1.
16. Employed by a tobacco or nicotine company, the study site, or handles tobacco or nicotine-containing products as part of their job.
17. Determined by the Investigator to be inappropriate for the study, including a subject who is unable to communicate or unwilling to cooperate with the clinical staff.