- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00428428
Pharmacological Modulation of the Intrarenal Pressure During Endourological Procedures in the Upper Urinary Tract
November 15, 2007 updated by: Fredericia Hosptial
The purpose of the study is to examine the effect of endoluminally administrated isoproterenol on pelvic pressure increase during flexible ureterorenoscopy in 14 humans.
We propose that isoproterenol has potential of reducing intrarenal pressure during ureterorenoscopies.
Lower intrarenal pressures may have the advantage of facilitating the procedure and reducing intraoperative complications as bleeding and infections.
Study Overview
Status
Completed
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
12
Phase
- Phase 2
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Fredericia, Denmark, 7000
- Dp. of Urology, Fredericia & Kolding Hospitals
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Indication for ureterorenoscopy
- Age> 18 years
- Normal blood pressure
Exclusion Criteria:
- Malignant disease in the upper urinary tract
- Heart disease
- Allergy to Isoproterenol
- Use of α-blocking or β-blocking medicine
- Use of Calcium-antagonists
- Use of NSAIDs the last 48 hours
- Present stone or JJ-stent in the ureter
- Neurologic disease in the bladder
- Pregnancy
- Nursing mothers
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Single Group Assignment
- Masking: Triple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Placebo Comparator: 1
Saline irrigation
|
ISO 0.1 microgram/ml, 8 ml/min irrigation compared to saline irrigation
|
Active Comparator: 2
ISO irrigation
|
ISO 0.1 microgram/ml, 8 ml/min irrigation compared to saline irrigation
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
---|
pelvic pressure
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Study Director: Palle JS Osther, PhD, MD, Dp. of Urology, Fredericia & Kolding Hospitals, Fredericia, denmark
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
February 1, 2007
Study Completion (Actual)
November 1, 2007
Study Registration Dates
First Submitted
January 29, 2007
First Submitted That Met QC Criteria
January 29, 2007
First Posted (Estimate)
January 30, 2007
Study Record Updates
Last Update Posted (Estimate)
November 16, 2007
Last Update Submitted That Met QC Criteria
November 15, 2007
Last Verified
November 1, 2007
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Pathologic Processes
- Kidney Diseases
- Urologic Diseases
- Hemorrhage
- Urination Disorders
- Pathological Conditions, Anatomical
- Urolithiasis
- Urinary Calculi
- Calculi
- Kidney Calculi
- Nephrolithiasis
- Hematuria
- Physiological Effects of Drugs
- Adrenergic Agents
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Autonomic Agents
- Peripheral Nervous System Agents
- Protective Agents
- Adrenergic Agonists
- Cardiotonic Agents
- Bronchodilator Agents
- Anti-Asthmatic Agents
- Respiratory System Agents
- Adrenergic beta-Agonists
- Sympathomimetics
- Isoproterenol
Other Study ID Numbers
- HJ2
- EudraCT nummer: 2006-005756-32
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Kidney Stone
-
Washington University School of MedicineRecruiting
-
Société Internationale d'UrologieCompletedStone Ureter | Stone, Kidney | Stone;RenalUnited States, China, Korea, Republic of, Malaysia, Saudi Arabia, Greece, India, Indonesia, Iran, Islamic Republic of, Iraq, Kenya, Romania, South Africa, Taiwan, Turkey
-
Wake Forest University Health SciencesCogenix Medical CorporationWithdrawnKidney Stone | Renal Stone | Ureter StoneUnited States
-
Advance Shockwave Technology GmbHUnknownKidney StonesUnited States
-
Mansoura UniversityCompletedUrologic Diseases | Stone, Kidney | Stone, Urinary | ESWL | Radiolucent Calculus of Urinary Tract | DissolutionEgypt
-
University of British ColumbiaActive, not recruiting
-
Mansoura UniversityUnknownUrologic Diseases | Stones, Kidney | Stone, Urinary | Shock Wave LithotripsyEgypt
-
Selçuk UniversityThe Scientific and Technological Research Council of TurkeySuspendedKidney StonesTurkey
-
Mansoura UniversityCompleted
-
Alnylam PharmaceuticalsTerminatedRecurrent Calcium Oxalate Kidney Stone Disease | Elevated Urinary Oxalate LevelsUnited States, Italy, Spain, Belgium, Switzerland, United Kingdom
Clinical Trials on Isoproterenol
-
ViriomCompleted
-
Pennington Biomedical Research CenterLipotheraCompleted
-
BayerCompletedContraceptionFinland, Estonia, Lithuania, Austria
-
Seoul National University HospitalNational Institute of Food and Drug Safety Evaluation, KoreaCompleted
-
Hadassah Medical OrganizationCompleted
-
Fredericia HosptialUnknownKidney Stone | UreteroscopyDenmark
-
Laureate Institute for Brain Research, Inc.National Institute of Mental Health (NIMH)CompletedAnorexia Nervosa | Brain Injury | Generalized Anxiety Disorder | Major Depressive Disorder | Panic DisorderUnited States
-
Laureate Institute for Brain Research, Inc.Brain & Behavior Research FoundationActive, not recruiting
-
University of AlbertaRecruitingVasodilation | VasoconstrictionCanada
-
NYU Langone HealthCompletedIntraoperative AwarenessUnited States