Interaction of Chronic Sleep Restriction and Circadian Misalignment on Sleep and Neuro-cognitive Performance

"Interaction of Chronic Sleep Restriction and Circadian Misalignment on Sleep and Neuro-cognitive Performance"

The primary objectives of the proposed experimental and modeling efforts are to quantify the influences of acute sleep deprivation (short-term homeostatic), chronic sleep restriction (long-term homeostatic), circadian rhythmicity, and their interactions on neurocognitive performance and to develop a new model of sleep homeostasis that can predict the effects of chronic sleep restriction. This model will be based on the underlying neuroanatomy and neurophysiology. This new model will facilitate optimization of human performance in operational settings, such as are seen in military operation and other work environments.

Study Overview

• Status: Completed
• Conditions: Healthy
• Intervention / Treatment: Behavioral: forced desynchrony protocol with sleep restriction

Detailed Description

This protocol involves a baseline period consisting of 14 hours of wakefulness and 10 hour nocturnal sleep episodes each 24 hours. This is followed by a forced desynchrony regimen spanning 21 calendar days and consisting of 12 cycles ("days") of a 42.85-hour wake:bedrest schedule. In each 42.85 hour cycle, there are 32.85 hours of scheduled wakefulness and 10 hour sleep opportunities. This will allow assessment of the independent contributions of circadian phase and homeostatic sleep pressure on sleep and neurobehavioral performance. This forced desynchrony regimen is followed by 10 recovery days consisting of 14 hours of wakefulness and 10 hour nocturnal sleep episodes each 24 hours.

• Study Type: Interventional
• Enrollment (Anticipated): 9
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Massachusetts
    • Boston, Massachusetts, United States, 02115
      • Brigham and Woman's Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 35 years (ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Age 18-35 years old
• Medically healthy

Exclusion Criteria:

• Sleep disorder
• Psychiatric illness
• Chronic medical condition
• No prescription or Non-prescription medications

Study Plan

How is the study designed?

Design Details

• Primary Purpose: HEALTH_SERVICES_RESEARCH
• Allocation: RANDOMIZED
• Interventional Model: CROSSOVER
• Masking: NONE

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Sleep Stage	38 days
Circadian Phase (melatonin rhythm)	38 days
Psychomotor Vigilance Task	38 days
Digit Symbol Substitution Task	38 days
Addition Task	38 days
Karolinska Sleepiness Scale	38 days
Karolinska Drowsiness Test	38 days
Mood Scales	38 days
Flanker Task	38 days
Multiple Object Tracking	38 days

Collaborators and Investigators

• Sponsor: Brigham and Women's Hospital
• Investigators: Principal Investigator: Elizabeth B Klerman, M.D., Ph.D., Brigham and Woman's Hospital; Principal Investigator: Charles A Czeisler, Ph.D., M.D., Brigham and Woman's Hospital

Study record dates

Study Major Dates

• Study Start: April 1, 2006
• Primary Completion (ACTUAL): November 1, 2008
• Study Completion (ACTUAL): November 1, 2008

Study Registration Dates

• First Submitted: February 20, 2007
• First Submitted That Met QC Criteria: February 21, 2007
• First Posted (ESTIMATE): February 22, 2007

Study Record Updates

• Last Update Posted (ESTIMATE): September 2, 2011
• Last Update Submitted That Met QC Criteria: August 31, 2011
• Last Verified: August 1, 2011

More Information

Terms related to this study

• Keywords: neurobehavioral performance; circadian rhythms; sleep restriction; forced desynchrony; sleep homeostasis
• Other Study ID Numbers: 2200-100792