- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01031459
Telephone Interview of Patients That Participated in the the Pivotal Betaferon MS Trial.
January 3, 2012 updated by: Bayer
An Observational 20-year, Cross-sectional, Long-term Follow up of the Patient Cohort Enrolled in the Pivotal Study of Betaseron® (Interferon Beta-1b) in Relapsing-remitting Multiple Sclerosis
The purpose of this study is to investigate the clinical status of patients who participated in the original pivotal Betaseron study at 20 years after randomized treatment initiationStudy end-points include:
- Mortality - All-cause mortality - Cause specific mortality - Multiple sclerosis-related mortality
- EDSS (Expanded Disability Status Scale)
- Cognition
- Resource use
- SPMS (Secondary Progressive Multiple Sclerosis) status
- Employment history
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Observational
Enrollment (Actual)
176
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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British Columbia
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Vancouver, British Columbia, Canada, V6T 2B5
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Ontario
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London, Ontario, Canada, N6A 5A5
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Quebec
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Montreal, Quebec, Canada, H3A 2B4
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Montreal, Quebec, Canada, H2L 4M1
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Alabama
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Birmingham, Alabama, United States, 35249
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Arizona
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Tucson, Arizona, United States, 85741-3537
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California
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San Francisco, California, United States, 94117
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Illinois
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Chicago, Illinois, United States, 60637-1470
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Maryland
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Baltimore, Maryland, United States, 21201
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Pennsylvania
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Philadelphia, Pennsylvania, United States, 19107
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Patients with MS that participated in the 16Y-LTF and Pivitol studies
Description
Inclusion Criteria:
- Previously enrolled in the Betaseron pivotal study protocols TB01-35686 in the US and TB01-35886 in Canada (total, N=372)
- Patient, caregiver, or legal guardian must provide written informed consent
- Patient must confirm her/his ability and agreement to participate in the study at the beginning of the phone call
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Cross-Sectional
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
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Group 1
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Telephone survey of all patients.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
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Descriptive exploration of mortality, EDSS, cognition, resource use, SPMS status and employment history by length of exposure to Betaseron and stratified by the original clinical trial group assignment (1.6 MIU, 8 MIU, placebo)
Time Frame: 20 years
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20 years
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2010
Primary Completion (Actual)
December 1, 2010
Study Completion (Actual)
December 1, 2010
Study Registration Dates
First Submitted
December 8, 2009
First Submitted That Met QC Criteria
December 10, 2009
First Posted (Estimate)
December 14, 2009
Study Record Updates
Last Update Posted (Estimate)
January 5, 2012
Last Update Submitted That Met QC Criteria
January 3, 2012
Last Verified
January 1, 2012
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pathologic Processes
- Nervous System Diseases
- Immune System Diseases
- Demyelinating Autoimmune Diseases, CNS
- Autoimmune Diseases of the Nervous System
- Demyelinating Diseases
- Autoimmune Diseases
- Multiple Sclerosis
- Sclerosis
- Physiological Effects of Drugs
- Anti-Infective Agents
- Antiviral Agents
- Antineoplastic Agents
- Immunologic Factors
- Adjuvants, Immunologic
- Interferons
- Interferon-beta
- Interferon beta-1b
Other Study ID Numbers
- 14261
- 20Y-LTF (Other Identifier: company internal)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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Clinical Trials on Betaseron (Interferon beta-1b, BAY86-5046)
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BayerCompletedMultiple SclerosisSwitzerland, Poland, France, Germany, Hungary, Spain, Sweden, Austria, Czech Republic, Italy, Slovenia, Israel, Belgium, Denmark, Netherlands, Canada, Norway, Finland
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BayerCompletedMultiple SclerosisFrance
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BayerCompletedRelapsing-Remitting Multiple SclerosisGermany
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BayerCompletedRelapsing Remitting Multiple Sclerosis (RRMS)China, Slovakia, France, Germany, Korea, Republic of, Saudi Arabia, Singapore, Sweden, Taiwan, Colombia, Czech Republic, Estonia, Italy, Jordan, Lebanon, Mexico, Slovenia, United Kingdom, Argentina, Bahrain, Egypt, United Arab Emirates and more
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BayerCompletedMultiple Sclerosis, Chronic ProgressiveChina
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BayerCompleted
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BayerCompleted
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BayerCompletedMultiple SclerosisSwitzerland, France, Germany, Indonesia, Korea, Republic of, Spain, Sweden, Thailand, Taiwan, Australia, Austria, Colombia, Czech Republic, Italy, Jordan, Kazakhstan, Lebanon, Mexico, Slovenia, United Kingdom, Bahrain, Egypt, United... and more
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BayerCompletedMultiple SclerosisGermany, Austria, United Kingdom, Israel, Belgium, Finland
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BayerCompletedMultiple SclerosisBelgium, Italy, Spain, France, Germany, Canada, Switzerland, Austria, Denmark, Hungary, Netherlands, Poland, Israel, United Kingdom, Finland, Sweden, Norway, Czech Republic, Portugal, Slovenia