The Impact of Post-tetanic Count on Subsequent Train-of-four During Recovery From Rocuronium

The purpose of this study is to see how long does the effect of a post-tetanic facilitation last on subsequent train-of-four. The investigators hypothesis is that the effect last at least 30 minutes.

Study Overview

• Status: Completed
• Conditions: Post-tetanic Count on One Arm, the Other Arm is the Control
• Intervention / Treatment: Device: NMT (a device that can do neurostimulation and can record the response on the stimulation by Datex)

• Study Type: Observational
• Enrollment (Anticipated): 22

Contacts and Locations

Study Locations

• Canada
  • Quebec
    • Montréal, Quebec, Canada, H1T 2M4
      • Hopital Maisonneuve-Rosemont

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 75 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Poeple having general anesthesia at HMR

Description

Inclusion Criteria:

• Patient having general anesthesia in dorsal decubitus with both arm available for at least an hour and a half

Exclusion Criteria:

• Age >75 or <18
• Neuromuscular disease
• difficult laryngoscopy predicted
• Allergy to rocuronium
• Malignant hyperthermia
• Full stomach
• Drugs the influence neuromuscular blockers
• Decision of the clinician to exclude his patient

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Patient-control	Device: NMT (a device that can do neurostimulation and can record the response on the stimulation by Datex); on one side, we do a post-tetanic count, on the other side we don't, after, we do train-of-four on both sides and check the difference

What is the study measuring?

Primary Outcome Measures

Outcome Measure
The difference at 30 minutes after the post-tetanic count between the TOF% in both arms, we expect a difference of more than 10%

Secondary Outcome Measures

Outcome Measure
The difference at 30 minutes after the post-tetanic count on the T1% (of the calibrated T1) in both arms, we expect a difference of more than 10%
The difference of the slope of recuperation on TOF and T1% after a post-tetanic count vs the control arm that had no tetanic stimulation

Collaborators and Investigators

• Sponsor: Maisonneuve-Rosemont Hospital

Study record dates

Study Major Dates

• Study Start: March 1, 2010
• Primary Completion (ACTUAL): April 1, 2010
• Study Completion (ACTUAL): April 1, 2010

Study Registration Dates

• First Submitted: March 10, 2010
• First Submitted That Met QC Criteria: March 11, 2010
• First Posted (ESTIMATE): March 12, 2010

Study Record Updates

• Last Update Posted (ESTIMATE): April 27, 2010
• Last Update Submitted That Met QC Criteria: April 26, 2010
• Last Verified: March 1, 2010

More Information

Terms related to this study

• Other Study ID Numbers: MaisonneuveRH-09092