Hämeenlinna Metabolic Syndrome Research Program: Oxidized LDL and Arterial Elasticity in Metabolic Syndrome and Controls (HMS-01) (HMS-01)

Hämeenlinna Metabolic Syndrome Research Program (HMS): Comparison of Men With Metabolic Syndrome and Their Physically Active Controls - Circulating Oxidized LDL and Arterial Elasticity

Mechanisms that link metabolic syndrome to atherosclerosis are incompletely understood. As a part of Hämeenlinna Metabolic Syndrome Research Program (HMS), 40 men with metabolic syndrome and their 40 physically active controls (age: 30 to 65 years) are compared in a cross-sectional study. Except routine laboratory parameters, arterial elasticity and levels of oxidized LDL are determined.

Study hypothesis: Levels of oxidized LDL and findings in arterial elasticity may differ between subjects with metabolic syndrome and controls explaining the elevated risk for cardiovascular diseases among patients with metabolic syndrome.

Study Overview

• Status: Completed
• Conditions: Metabolic Syndrome

Detailed Description

Accumulation of oxidized low-density lipoproteins in the intimae of arteries together with risk factors known to enhance atherosclerosis, damage the endothelium of the arterial wall. Dysfunction of the endothelium leads into loss of elasticity of the artery. Especially a reduction in the elasticity of small arteries has been found prominent in atherosclerosis and is believed to serve as a marker for early stages of atherosclerosis.

In this study, we investigate whether the levels of oxidized LDL and arterial elasticity differ between patients with metabolic syndrome and their physically active controls. Oxidized LDL is assessed by a two-site ELISA immunoassay (Mercodia, Uppsala, Sweden). The capacitive elasticity of large arteries (C1) and the reflective elasticity of small arteries (C2) are automatically assessed by the CR-2000 as a mean of five most similar pulse waves appearing during the measurement. C1 identifies the elastic properties of aorta and other large arteries, C2 the endothelial function of the microvascular circulation. Proper statistical methods are used to reveal possible differences and their significance between the patients and controls.

• Study Type: Observational
• Enrollment (Actual): 80

Contacts and Locations

Study Locations

• Finland
  • Hämeenlinna, Finland, 13100
    • Linnan Klinikka
  • Hämeenlinna, Finland, 13530
    • Central Hospital of Kanta-Häme

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 30 years to 65 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

• Sampling Method: Non-Probability Sample

Study Population

Primary care clinic.

Description

Inclusion Criteria:

Group 1: Metabolic syndrome

• 40 Finnish men with metabolic syndrome (MetS) defined according to National Cholesterol Education Program (NCEP) Adult Treatment Panel III
• MetS diagnosed in routine health examination and laboratory tests
• Age: 30 to 65 years

Group 2: Control

• 40 age-matched men
• Exercise physically more than three times a week and more than 30 minutes per exercise on regular basis
• Never been studied or treated because of cardiovascular disease

Exclusion Criteria:

• Cholesterol-lowering medication
• ACE-inhibitor medication
• Angiotensin-receptor blocker medication

Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Control
• Time Perspectives: Cross-Sectional

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Metabolic syndrome; 40 men with metabolic syndrome
Control; 40 physically active men

Collaborators and Investigators

• Sponsor: Kanta-Häme Central Hospital
• Collaborators: Linnan Klinikka Oy

Publications and helpful links

General Publications

• Pohjantahti-Maaroos H, Palomaki A, Kankkunen P, Laitinen R, Husgafvel S, Oksanen K. Circulating oxidized low-density lipoproteins and arterial elasticity: comparison between men with metabolic syndrome and physically active counterparts. Cardiovasc Diabetol. 2010 Aug 20;9:41. doi: 10.1186/1475-2840-9-41.

Study record dates

Study Major Dates

• Study Start: June 1, 2003
• Primary Completion (Actual): November 1, 2005
• Study Completion (Actual): September 1, 2007

Study Registration Dates

• First Submitted: April 30, 2010
• First Submitted That Met QC Criteria: April 30, 2010
• First Posted (Estimate): May 3, 2010

Study Record Updates

• Last Update Posted (Estimate): May 4, 2010
• Last Update Submitted That Met QC Criteria: May 3, 2010
• Last Verified: April 1, 2010

More Information

Terms related to this study

• Keywords: Cardiovascular Diseases; Diabetes Mellitus; Metabolic Syndrome; Arterial Elasticity; Oxidized Low Density Lipoprotein
• Additional Relevant MeSH Terms: Pathologic Processes; Glucose Metabolism Disorders; Metabolic Diseases; Disease; Insulin Resistance; Hyperinsulinism; Syndrome; Metabolic Syndrome
• Other Study ID Numbers: KHMetS-01-AP