Triclosan Toothpaste and Third Molar Surgery

Effect of a Triclosan Containing Dentifrice on Oral Bacteria and Postoperative Complications Following Third Molar Surgery

Triclosan containing dentifrices are effective in the prevention of inflammatory complications following third molar surgery through reducing preoperative oral bacteria load.

Study Overview

• Status: Completed
• Conditions: Wound Infection; Dry Socket
• Intervention / Treatment: Other: Colgate Total Toothpaste; Other: Colgate Regular Toothpaste

Detailed Description

This study may provide evidence on the effect of triclosan containing dentifrice on oral bacteria and oral inflammation prior to third molar surgery, and on the incidence of inflammatory complications after the surgery. If proven effective, dentifrice containing triclosan may be recommended prior to tooth extractions and replace antibiotics and other antimicrobial products as a prophylactic procedure before oral surgery procedures.

• Study Type: Interventional
• Enrollment (Actual): 141
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • New York
    • Rochester, New York, United States, 14620
      • University of Rochester Eastman Dental Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 16 years to 33 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• must include at least one mandibular third molar with partial or full bony impaction
• no sign of active pericoronal (around the crown) infections
• must have not taken antibiotics for any reason in the past 30 days
• must be healthy and between 18 and 35 years of age
• must be able to read and sign an informed consent

Exclusion Criteria:

• Subjects with systemic diseases and pregnant or lactating women
• Subjects with advanced periodontal diseases or having two or more untreated caries lesions
• Subjects who cannot read and sign an informed consent
• Subjects with signs of pericoronal infections

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Triple

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
dry socket	Development of dry socket (alveolar osteitis) 3 to 7 days after tooth extraction	3 to 7 days

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
wound infection	Development of tooth extraction wound infection 3 to 7 days after extraction	3 to 7 days

Collaborators and Investigators

• Sponsor: University of Rochester
• Investigators: Principal Investigator: Yanfang Ren, DDS, MPH, University of Rochester Eastman Dental Center

Study record dates

Study Major Dates

• Study Start: February 1, 2008
• Primary Completion (Actual): February 1, 2013
• Study Completion (Actual): February 1, 2013

Study Registration Dates

• First Submitted: February 4, 2011
• First Submitted That Met QC Criteria: February 7, 2011
• First Posted (Estimate): February 9, 2011

Study Record Updates

• Last Update Posted (Estimate): October 28, 2015
• Last Update Submitted That Met QC Criteria: October 26, 2015
• Last Verified: October 1, 2015

More Information

Terms related to this study

• Keywords: wound infection; triclosan; toothpaste; dry socket; third molars
• Additional Relevant MeSH Terms: Infections; Stomatognathic Diseases; Mouth Diseases; Wound Infection; Dry Socket; Physiological Effects of Drugs; Molecular Mechanisms of Pharmacological Action; Anti-Infective Agents, Local; Anti-Infective Agents; Antimetabolites; Protective Agents; Hypolipidemic Agents; Lipid Regulating Agents; Cariostatic Agents; Fatty Acid Synthesis Inhibitors; Listerine; Fluorides; Sodium Fluoride; Triclosan
• Other Study ID Numbers: UREDC3rd