Interferential Electrical Stimulation and Vasodilatation in Healthy Individuals (InterM)

Interferential Electrical Stimulation Improves Peripheral Vasodilatation in Healthy Individuals: A Randomized Crossover Study

Interferential electrical stimulation (IES) increases local blood flow. It is not known whether increases in blood flow may be caused by inhibition of sympathetic activity, mediated by muscle metaboreflex activity. The purpose of this study was to evaluate the effect of IES on metaboreflex activation in healthy subjects.

Study Overview

• Status: Completed
• Conditions: Decreased Vascular Flow
• Intervention / Treatment: Device: Interferential; Device: Interferential Placebo

Detailed Description

The study sample consisted of 11 healthy young individuals. All subjects were non-smokers, non-obese and free of any signs or symptoms of disease, as revealed by medical history, physical examination and electrocardiogram at rest and during cardiopulmonary exercise testing. Exclusion criteria were pregnancy, breast-feeding, alcohol or drug abuse, and any medication with potential effects on cardiovascular variables. Subjects were asked not to drink caffeine-containing drinks or exercise for at least 12 and 48 hours, respectively, before the experimental protocols.

• Study Type: Observational
• Enrollment (Actual): 11

Contacts and Locations

Study Locations

• Brazil
  • DF
    • Brasilia, DF, Brazil
      • University of Brasilia
  • RS
    • Porto Alegre, RS, Brazil, 90035-007
      • Hospital de Clínicas de Porto Alegre
    • Porto Alegre, RS, Brazil, 90820-001
      • Gaspar Rogério da Silva Chiappa

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 40 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Healthy subjects without degenerative diseases.

Description

Inclusion Criteria:

• Subjects are non-smokers
• non-obese
• and free of any signs or symptoms of disease

Exclusion Criteria:

• Pregnancy
• breast-feeding
• alcohol or drug abuse
• medication with potential effects on cardiovascular variables

Study Plan

How is the study designed?

Design Details

• Time Perspectives: Prospective

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Interferential; The individuals are treated acutely with interferential electrical stimulation (IES) during 30 min, providing a continuous flow of symmetrical rectangular interferential current biphasic pulses using bipolar electrodes with two channels and a slope of 1/5/1. The fixed current is adjusted to 4000 Hz, with the current AMF at 100 Hz and an AMF variation of 25 Hz (25% of AMF).	Device: Interferential; The individuals are treated acutely with IES during 30 min, providing a continuous flow of symmetrical rectangular interferential current biphasic pulses using bipolar electrodes with two channels and a slope of 1/5/1. The fixed current is adjusted to 4000 Hz, with the current AMF at 100 Hz and an AMF variation of 25 Hz (25% of AMF).; Other Names: Transcutaenous electrical stimuation
Placebo; The same instructions and electrode positions were provided to the placebo, although the equipment did not provide any stimulation current	Device: Interferential Placebo; The same instructions and electrode positions were provided to the placebo, although the equipment did not provide any stimulation current

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Muscle Metaboreflex Reflex	Calf blood flow	Participants will be followed for the duration of metaboreflex activity (up to 30 minutes)

Collaborators and Investigators

• Sponsor: Hospital de Clinicas de Porto Alegre
• Collaborators: University of Brasilia
• Investigators: Principal Investigator: Gaspar R Chiappa, Dr, Hospital de Clínicas de Porto Alegre

Publications and helpful links

General Publications

• Vieira PJ, Ribeiro JP, Cipriano G Jr, Umpierre D, Cahalin LP, Moraes RS, Chiappa GR. Effect of transcutaneous electrical nerve stimulation on muscle metaboreflex in healthy young and older subjects. Eur J Appl Physiol. 2012 Apr;112(4):1327-34. doi: 10.1007/s00421-011-2084-z. Epub 2011 Jul 28.

Study record dates

Study Major Dates

• Study Start: July 1, 2011
• Primary Completion (Actual): September 1, 2012
• Study Completion (Actual): October 1, 2012

Study Registration Dates

• First Submitted: August 26, 2011
• First Submitted That Met QC Criteria: October 10, 2011
• First Posted (Estimate): October 12, 2011

Study Record Updates

• Last Update Posted (Estimate): January 24, 2013
• Last Update Submitted That Met QC Criteria: January 23, 2013
• Last Verified: January 1, 2013

More Information

Terms related to this study

• Keywords: Exercise; Autonomic Nervous System; Neuromodulation; Blood flow control
• Other Study ID Numbers: 11-0374

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No