Comparison of Blood Cardioplegia and Custodiol

Comparison of Blood Cardioplegia and Custodiol on Patients Operated for Significant Mitral Valve Innsufisiens. An Prospective, Randomized Two-center Study.

Thru the last 20 years it has been a discussion witch solution that gives the best myocardial protection during cardiac arrest by heart operations.

• It has been a tendency that a blood based cardioplegia gives a better protection bye long ischemic times but it has not been possible too conclude in this matter.
• The investigators have two groups of cardioplegia, the blood based and, the crystalloid based cardioplegia.
• It has been done a lot of studies to see what kind of cardioplegia that gives the best myocardial protection. Different temperature, different amount and content, retrograde or antegrade or both, contentiously and further on have been tested without a clear conclusion.
• The investigators decided to make a study with a cohort of patients as homogenous as possible with a cross clamp time around 70 min.
• Adult patients' with a severe aortic stenoses without any other significant heart disease was included in our prospective randomised study.
• Patients with additional significant coronary artery disease (≥ 50% stenoses) were excluded from the study.
• The investigators used the well known biomarkers CK-MB and troponin-T too evaluate the myocardial damage.

Study Overview

• Status: Completed
• Conditions: Myocardial Protection; Mitral Insufficiencies

Detailed Description

Objective: Myocardial protection during a cardiac arrest is mostly managed with cardioplegia. To day we normally used a blood or crystalloid based solutions. It has been published a lot of papers comparing the too groups with different results. To our knowledge no prospective, randomized study has compared modified St Thomas based Blood and Crystalloid cardioplegia on the acknowledged markers (CK-MB, troponin-T) of myocardial damage during aortic valve replacement on patients without additional significant coronary artery disease.

Methods: 100 patients with aorta stenoses undergoing aortic valve replacement without significant coronary artery stenoses or other significant concomitant heart valve disease were included in the study. They were given antegrade cold blood or cold crystalloid cardioplegia delivered through the coronary Ostia every 20 min throughout the period of aortic cross-clamp. CK-MB and troponin-T were compared between the two groups.

Published 2010 in the journal of thoracic and cardiovascular surgery.

• Study Type: Observational
• Enrollment (Actual): 76

Contacts and Locations

Study Locations

• Norway
  • Oslo, Norway
    • thoraxkirurgisk avd, UUS

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Between Mars 2007 and December 2009, 80 consecutive patients undergoing elective mitral valve surgery for mitral regurgitation at Oslo University Hospital Ullevål, Oslo, Norway and Sahlgrenska University Hospital, Gothenburg, Sweden were included in the study after informed written consent.

Description

The study protocol was approved by the local ethical committees. Eligible for operation were:

Inclution Criteria

• patients with mitral regurgitation equal to or larger than grade 3 out of 4.
• Ablation for atrial fibrillation was the only concomitant procedure that was allowed in addition to mitral valve surgery and these patients were block-randomized to ensure equally many patients with ablation in the two groups of cardioplegia.

Exclusion Criteria

• Patients with any other concomitant heart valve disease or coronary artery stenoses (≥ 50%) were excluded from the study.
• Age below 18
• Pregnant

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
1 Custodiol; Custodiol
2 Blood cardioplegia; Blood cardioplegia

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
CK-MB ,troponin-T	72 hours

Collaborators and Investigators

• Sponsor: Ullevaal University Hospital
• Investigators: Study Director: Theis Tønnessen, prof.dr.med, Thoraxkirurgisk avd. UUS; Study Chair: Bjørn Braathen, med.doc, Thoraxkir.avd. UUS

Study record dates

Study Major Dates

• Study Start: March 1, 2007
• Primary Completion (Actual): December 1, 2009
• Study Completion (Actual): January 1, 2010

Study Registration Dates

• First Submitted: May 7, 2012
• First Submitted That Met QC Criteria: September 12, 2013
• First Posted (Estimate): September 13, 2013

Study Record Updates

• Last Update Posted (Estimate): September 13, 2013
• Last Update Submitted That Met QC Criteria: September 12, 2013
• Last Verified: September 1, 2013

More Information

Terms related to this study

• Keywords: CK-MB; troponin-T
• Additional Relevant MeSH Terms: Heart Diseases; Cardiovascular Diseases; Heart Valve Diseases; Mitral Valve Insufficiency
• Other Study ID Numbers: 2007-001780-30