Supraspinal Contributions to the Control of Human Locomotion: Clinical and Fundamental Aspects (SUPLOCO)

Many neurological patients express enhanced deficits while walking in a dark room (or during the night): the supraspinal structures involved in this navigational deficit have not been identified yet. In this project, the investigators will study post-stroke gaits of human patients and compare them to those of a control population during a goal-oriented task performed in different visual conditions.

The investigators want to test the hypothesis that during simple goal-oriented locomotor tasks, only patients with specific (e.g. medio or infero- temporal) lesions will express navigational deficits.

Study Overview

• Status: Completed
• Conditions: Post-stroke Gait Assessments
• Intervention / Treatment: Behavioral: Kinematic measurements

• Study Type: Observational
• Enrollment (Actual): 20

Contacts and Locations

Study Locations

• Switzerland
  • Fribourg, Switzerland, 1700
    • University (UNIFR) and Hospital of Fribourg (HFR)

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 85 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

The selected patients will be described by following parameters:

• Parameters in relation to the person: age, gender.
• Parameters in relation to the pathology: NIHSS, exact localisation, time since start of the symptoms, FIM (functional independence measure) visual field (ophthalmological examen), visual acuity (ophtalmological examen), visual neglect (Bells Cancellation Task), visuo-spatial short term working memory (Corsi span), visual motor integration (3-D cub subtest MoCA)
• Parameters in relation to hospital stay: length of stay.

Description

Inclusion Criteria (for matching controls):

• Adult male and female subjects (18-->85 years old)

Exclusion Criteria (for matching controls):

• Persons with history of an acquired or congenital neurological disorder, e.g. stroke, multiple sclerosis, Parkinson disease, increased intracranial pressure, etc.;
• Persons injured at the time of the experiments (fractures,…);
• Persons having reported repetitive spatial troubles/disorders;
• Persons with eye disorders and non-corrected vision problems;
• Pregnant women.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Post-stroke patients; Patients who experienced stroke and who already recover gait abilities.	Behavioral: Kinematic measurements
Control population; Participants matching the criterion (age and gender) of the patients' group.	Behavioral: Kinematic measurements

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Walking stability indices of post-stroke patients	1 hour and 30 minutes (including pre-tests, instructions delivery...).
Spatial accuracy of walking trajectories in post-stroke patients	1 hour and 30 minutes (including pre-tests, instructions delivery...).

Collaborators and Investigators

• Sponsor: University of Fribourg
• Collaborators: Dr Titus Bihl, Hopital Cantonal Fribourgeois

Study record dates

Study Major Dates

• Study Start: March 1, 2014
• Primary Completion (Actual): January 1, 2015
• Study Completion (Actual): March 1, 2016

Study Registration Dates

• First Submitted: October 6, 2014
• First Submitted That Met QC Criteria: October 8, 2014
• First Posted (Estimate): October 13, 2014

Study Record Updates

• Last Update Posted (Actual): October 25, 2017
• Last Update Submitted That Met QC Criteria: October 24, 2017
• Last Verified: October 1, 2017

More Information

Terms related to this study

• Other Study ID Numbers: UFribourg