- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02325570
Evaluation of the KLOX BioPhotonic OraLum Gel With a LED Curing Lamp in Moderate to Severe Chronic Periodontitis
February 22, 2016 updated by: KLOX Technologies Inc.
The Evaluation of the Clinical Effects of the KLOX BioPhotonic OraLum Gel With a LED Curing Lamp as an Adjunct to the Non-Surgical Treatment of Moderate to Severe Chronic Periodontitis
Multicenter, prospective, interventional open case series study using a randomized split-mouth design in moderate to severe chronic periodontitis patients having half-mouth treated with the KLOX BioPhotonic OraLum gel with a LED curing lamp as an adjunct to conventional non-surgical periodontal treatment (SRP) versus SRP alone in the second (control) half-mouth.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
30
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Quebec
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Montreal, Quebec, Canada, H4X 2E9
- Dr. Anthony Seminara Inc.
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Signed and dated written informed consent form;
- Male or female patients aged 18 years old and above;
- Good general health, free of systemic diseases such as diabetes, arthritis, HIV infection or genetic disorder that could influence the outcome of the treatment;
- Patient with clinically confirmed signs and symptoms of generalized moderate to severe chronic periodontitis (as defined according to International Classification of Periodontal Diseases, Armitage 1999);
- Patient has had no periodontal treatment for the last year prior to the study;
Females of childbearing potential must not be pregnant nor lactating at study entry and agree to use an adequate contraceptive method during the study.
Inclusion Criteria Post Oral Hygiene Instructions (OHI):
- Patient demonstrates sufficient plaque control as indicated by a plaque score < 30% after hygiene period;
- Patient has at least two sites in each quadrant with probing pocket depth (PPD) equal or more than 5 mm or equal or less than 7 mm.
Exclusion Criteria:
- Patient with an existing aggressive periodontitis;
- Presence of oral local mechanical factor(s) that could, in the opinion of the investigator, influence the outcome of the study;
- Presence of orthodontic appliances, or any removable appliances, that impinges on the tissues being assessed;
- Soft or hard tissue tumours of the oral cavity;
- Systemic antibiotic therapy or anti-inflammatory drugs or any other medication(s) that might interfere with periodontal healing within the last three months prior to study entry and throughout the study duration;
- Patient has participated in any other clinical study within 30 days prior to study entry and throughout the study duration;
- Use of anticoagulants such as warfarin, clopidogrel, enoxaparin or high doses of aspirin (162 mg daily);
- Regular use of chlorhexidine oral rinses / mouthwashes (Non-medicated, over the counter, mouthwashes are acceptable);
- Patient with current alcohol abuse or actively consuming drugs (addiction); as it may interfere with patient's ability to comply with study procedures
- Periodontal surgery planned during the study;
- Female patient pregnant, nursing or planning to become pregnant within the next 12 months;
- Patient is a current smoker or had been smoking or using nicotine product(s) in the last six months;
- Concurrent disease (such as porphyria) or drug(s) (such as methotrexate or chloroquine) known to induce severe photosensitivity of the skin;
- Patient has ongoing malignant disease of any type, or any significant chronic disease which, in the opinion of the investigator, might interfere with the evaluation of the study objectives or would result in non-compliance with the study protocol;
- Patients with known hypersensitivity to peroxide;
- Patients with known photosensitivity or who take drugs to treat photosensitivity.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: KLOX BioPhotonic OraLum Gel + SRP
Split-mouth design:the half-mouth randomly selected will be treated with KLOX BioPhotonic OraLum gel (with a LED curing lamp) as an adjunct to SRP.
|
Klox BioPhotonic OraLum Gel will be used with a LED curing lamp as an adjunct to conventional non-surgical periodontal treatment (SRP).
Scaling and Root Planing (SRP) is the conventional non-surgical treatment of chronic periodontitis.
|
Other: Scaling and Root Planing (SRP)
The second half-mouth will be treated with SRP alone.
|
Scaling and Root Planing (SRP) is the conventional non-surgical treatment of chronic periodontitis.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Adverse events, Serious adverse events and incidents
Time Frame: 3 weeks
|
Number of patients with adverse events, serious adverse events and incidents
|
3 weeks
|
Ease of performing SRP and time required to perform SRP
Time Frame: 2 weeks
|
2 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Impact on tissues (Visual examination of tissues)
Time Frame: 3 weeks
|
Visual examination of tissues
|
3 weeks
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Impact on bleeding (Use of Bleeding on Probing (BOP) results)
Time Frame: 2 weeks
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Use of Bleeding on Probing (BOP) results
|
2 weeks
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Impact on Plaque Index (PI)
Time Frame: 2 weeks
|
2 weeks
|
|
Impact on Gingival index (GI)
Time Frame: 2 weeks
|
2 weeks
|
|
Pain (Visual Analog Scale)
Time Frame: 2 weeks
|
2 weeks
|
Other Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Exploratory endpoint: patient's preference questionnaire
Time Frame: 2 weeks
|
2 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Anthony Seminara, DDM, Dr. Anthony Seminara Inc.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
November 1, 2014
Primary Completion (Actual)
March 1, 2015
Study Completion (Actual)
May 1, 2015
Study Registration Dates
First Submitted
December 17, 2014
First Submitted That Met QC Criteria
December 24, 2014
First Posted (Estimate)
December 25, 2014
Study Record Updates
Last Update Posted (Estimate)
February 23, 2016
Last Update Submitted That Met QC Criteria
February 22, 2016
Last Verified
February 1, 2016
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- CL-K1004-P001
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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