Intraoperative Sedation and Postoperative Delirium

Prevalence of Postoperative Delirium According to the Use of Dexmedetomidine or Propofol in Elderly Patients Undergoing Orthopedic Surgery: Retrospective Study

Delirium are common after orthopedic surgery in the elderly and are directly associated with loss of independence, reduction in the quality of life and increased mortality. The cause of postoperative delirium still remains unclear and may be multifactorial. The aim of this retrospective study is to examine prevalence of postoperative delirium according to the use of dexmedetomidine or propofol in elderly patients undergoing orthopedic surgery under regional anesthesia.

Study Overview

• Status: Completed
• Conditions: Orthopedics
• Intervention / Treatment: Drug: Dexmedetomidine; Drug: Propofol

• Study Type: Observational
• Enrollment (Actual): 855

Contacts and Locations

Study Locations

• Korea, Republic of
  • Gyeonggi
    • Seongnam, Gyeonggi, Korea, Republic of
      • Seoul National University Bundang Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years and older (Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Patients who underwent orthopedic surgery under regional anesthesia, and age of 65 years or greater

Description

Inclusion Criteria:

• Patients who underwent orthopedic surgery under regional anesthesia
• age of 65 years or greater

Exclusion Criteria:

• General anesthesia
• age < 65 years
• central nervous system disease, including dementia and Parkinson's disease
• Patients who were not received sedation with propofol or dexmedetomidine during the operation

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
DEX; patients who received dexmedetomidine during the operation	Drug: Dexmedetomidine
PPF; patients who received propofol during the operation	Drug: Propofol

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
delirium	within 7 day postoperatively

Secondary Outcome Measures

Outcome Measure	Time Frame
Wound infection	within 7 day postoperatively
Pulmonary thromboembolism	within 7 day postoperatively
Hospital stay	through study completion, an average of 7days

Other Outcome Measures

Outcome Measure	Time Frame
Myocardial ischemia	within 7 day postoperatively
Renal failure	within 7 day postoperatively
Hepatic failure	within 7 day postoperatively

Collaborators and Investigators

• Sponsor: Seoul National University Bundang Hospital

Study record dates

Study Major Dates

• Study Start: October 1, 2015
• Primary Completion (Actual): January 1, 2016
• Study Completion (Actual): January 1, 2016

Study Registration Dates

• First Submitted: October 6, 2015
• First Submitted That Met QC Criteria: October 7, 2015
• First Posted (Estimate): October 12, 2015

Study Record Updates

• Last Update Posted (Estimate): April 6, 2016
• Last Update Submitted That Met QC Criteria: April 5, 2016
• Last Verified: April 1, 2016

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Nervous System Diseases; Neurologic Manifestations; Confusion; Neurobehavioral Manifestations; Neurocognitive Disorders; Delirium; Physiological Effects of Drugs; Adrenergic Agents; Neurotransmitter Agents; Molecular Mechanisms of Pharmacological Action; Central Nervous System Depressants; Peripheral Nervous System Agents; Analgesics; Sensory System Agents; Anesthetics, Intravenous; Anesthetics, General; Anesthetics; Analgesics, Non-Narcotic; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic Agonists; Hypnotics and Sedatives; Propofol; Dexmedetomidine
• Other Study ID Numbers: B-1510/318-104