- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02647177
A Prospective Study To Identify Predictive Biological Markers In Blood And Cyst Fluid Aspirates From Patients With Pancreatic Cyst Lesions
The purpose To determine the diagnostic potential of various biological markers in blood and cyst fluid aspirates from patients with Pancreatic Cystic Lesions (PCLs).
Research design This is a 10-year prospective cohort and pancreatic cyst fluid repository study enrolling all patients diagnosed with pancreatic cyst and undergoing the cyst aspiration.
Procedures to be used Blood Sample Cyst Fluid Sample
Data Collection:
Medical Record Number Demographics (age, sex, gender, race) Contact information History of alcohol use and IV and other recreational drugs and narcotics use/abuse Medication history Past hospitalizations, diagnoses, and treatment Physical examination findings Imaging data of abdominal and chest regions, including and not limited to ultrasonography, magnetic resonance imaging (MRI), computed tomography (CT) Future admissions, diagnoses, treatment including histopathological findings of resected specimens and blood reports End of study data: clinical progression of disease, cyst size, wall thickening, calcification, communication with pancreatic duct, string sign, cytology, immunohistochemical findings, assay levels of lipase, amylase CEA (carcinoembryonic antigen), carbohydrate antigen19-9 (CA 19-9), and other biomarkers.
Risks and potential benefits The risks associated with this study are slight discomfort or bruising from the blood sampling and the possible loss of confidentiality if the patient data or information is inadvertently disclosed outside of this study. The patient will not receive any additional benefit from the study aside from those received as part of routine standard of care.
Importance of knowledge that may reasonably be expected to result The knowledge gained from this study may benefit other patients with Pancreatic Cyst Lesions in the future.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Prithvi Patil, MS
- Phone Number: (713) 500-6654
- Email: prithvi.b.patil@uth.tmc.edu
Study Contact Backup
- Name: Priyanka Priyanka, BAMS, MPH
- Phone Number: 7135006457
- Email: priyanka.priyanka@uth.tmc.edu
Study Locations
-
-
Texas
-
Houston, Texas, United States, 77030
- Recruiting
- The University of Texas Health Science Center at Houston
-
Contact:
- Bijun Kannadath, MBBS
- Phone Number: 713-500-6654
- Email: bijun.s.kannadath@uth.tmc.edu
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Diagnosis of Pancreatic Cystic Lesions (PCLs) or Acute Pancreatitis (AP) or chronic pancreatitis(CP) or Pancreatic Cancer (PC) (any stage/grade) or congenital developmental anomalies of the pancreas.
- Any combination of the diagnoses above.
- Patients must provide written informed consent for the collection of blood specimens for research purposes.
- Patients with PCLs must provide informed consent for collection of excess cyst fluid aspirate remaining after testing for routine standard of care
- Patients with pancreatic Cystic Lesions (PCLs) or AP or CP or PC (any stage/grade) or congenital developmental anomalies of the pancreas undergoing surgery must provide informed consent for collection of surgical specimen
Exclusion Criteria:
- Patients with co-existing malignancies of other organs (or prior history of such)
- Patients unable to provide informed consent
- Patients unable to complete follow up
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Pancreatic Cyst Group
Only the eligible participant in the study are considered for inclusion in this group.
|
10 CC of pancreatic cyst aspiration
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Detection of early progression to Tumor
Time Frame: 2 years
|
To identify any correlation between higher expression levels with early progression to malignant changes in the pancreas
|
2 years
|
Collaborators and Investigators
Investigators
- Principal Investigator: Nirav C Thosani, MD MHA, The University of Texas Health Science Center, Houston
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- HSC-MS-14-0980
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Pancreatic Cystic Lesions
-
Boston Scientific CorporationCompletedPancreatic Cystic LesionsUnited States, China, India
-
The Mediterranean Institute for Transplantation...Not yet recruitingStress | Pancreatic Cancer | Anxiety | Pancreatic Cystic LesionsItaly
-
The University of Texas Health Science Center,...Recruiting
-
National Taiwan University HospitalCompleted
-
National Taiwan University HospitalRecruiting
-
The Third Xiangya Hospital of Central South UniversityCompletedPancreatic Solid LesionsChina
-
ARNAS Civico Di Cristina Benfratelli HospitalCompletedPancreatic Solid LesionsItaly
-
University of Alabama at BirminghamCompleted
-
Nanfang Hospital of Southern Medical UniversityShenzhen People's Hospital; Second Affiliated Hospital of Guangzhou Medical...Not yet recruitingSolid Pancreatic Lesions | EUS-FNB
-
Università Vita-Salute San RaffaeleCompletedPancreatic Lesions Located at Body or Tail.Italy
Clinical Trials on Pancreatic Cyst Aspiration
-
Hillel Yaffe Medical CenterUnknown
-
Mayo ClinicNational Cancer Institute (NCI)Recruiting
-
University of PittsburghVA Pittsburgh Healthcare System; American Society for Gastrointestinal EndoscopyCompletedPancreatic Cyst | Pancreatic Neoplasm | Pancreatic PseudocystUnited States
-
Shaimaa Mostafa Mohammed Refaay El shemyCompletedOvarian EndometriomaEgypt
-
Ochsner Health SystemCompleted
-
Ohio State UniversityRecruitingPancreatic Cyst | Radiofrequency AblationUnited States
-
University Hospital, ToursCompletedOvarian Cyst | Ultrasonography PrenatalFrance
-
Hospital St. Joseph, Marseille, FranceRamsay Générale de SantéActive, not recruitingPancreatic Cyst | IPMN | Pancreas Cyst | Serous Cystadenoma | Mucinous CystadenomaFrance
-
AdventHealthUnknown
-
Asian Institute of Gastroenterology, IndiaNot yet recruiting