Methodological Developments for Magnetic Resonance Imaging (MRI) (METHODO)

March 4, 2026 updated by: Valérie LAURENT, Central Hospital, Nancy, France

Développement Méthodologique de l'Imagerie Par Résonance Magnétique (IRM)

The purpose of this study is to optimize clinical MR protocols and to validate MR acquisition parameters.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

1807

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Nancy, France, 5400
        • CHRU de Nancy

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • to be over 18 year-old,
  • to be able to give an informed consent,
  • to have underwent a pre-inclusion medical examination,
  • to present no contraindication to MR examination,
  • to be enrolled in a social security plan.

Exclusion Criteria:

  • subject refusal,
  • subject under a measure of legal protection,
  • any contraindication to MR examination (active medical device, ferromagnetic foreign body, pregnancy, morbid obesity, claustrophobia, … ).

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: All subjects
All subjects will have an MRI examination
Device: MRI

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Image quality based on standard imaging quality criteria
Time Frame: 6 months after the last inclusion

Image quality criteria will be :

  • Signal to Noise Ratio and Contrast to Noise Ratio measured in arbitrary units.
  • absence of blurring and artefacts will be assessed by at least one radiologist according to an ordinal scale
6 months after the last inclusion

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
T1/T2 Quantitative sub studies
Time Frame: 6 months after the last inclusion
For quantitative studies such as T1/T2 studies a T1/T2 quantification will be calculated. These parameters will be reported in ms.
6 months after the last inclusion
Brain Functional MRI sub studies
Time Frame: 6 months after the last inclusion
For functional MRI studies, brain activity will be described in terms of brain localisation based on blood oxygen level-dependent signal variation and its intensity.
6 months after the last inclusion
Cardiac function MRI sub studies: volume
Time Frame: 6 months after the last inclusion
For cardiac imaging, cardiac function will be evaluated. Parameters such as left ventricle (LV) and right ventricle (RV) end-diastolic volumes end-systolic volumes will be measured and reported in mL/m².
6 months after the last inclusion
Cardiac mass MRI sub studies: mass
Time Frame: 6 months after the last inclusion
For cardiac imaging, cardiac function will be evaluated. LV and RV mass index will be measured and reported in g/m2.
6 months after the last inclusion
Cardiac function MRI sub studies: ejection fraction
Time Frame: 6 months after the last inclusion
For cardiac imaging, cardiac function will be evaluated. Ejection fraction for both ventricles will be calculated and reported in %.
6 months after the last inclusion
Diffusion weighted MRI sub studies
Time Frame: 6 months after the last inclusion
For diffusion studies, the apparent diffusion coefficient (ADC) whic is a measure of the magnitude of diffusion (of water molecules) within tissue will be estimated (mm2/s).
6 months after the last inclusion
Diffusion tensor MRI sub studies
Time Frame: 6 months after the last inclusion
The fractional anisotropy (FA) which is a scalar value between zero and one, which describes the degree of anisotropy of a diffusion process, could also be estimated.
6 months after the last inclusion

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Central Hospital, Nancy, France

Investigators

  • Principal Investigator: Valérie Laurent, MD,PhD, CHRU de Nancy
  • Principal Investigator: Jacques Felblinger, MD,PhD, CHRU de Nancy

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 1, 2008

Primary Completion (Actual)

May 26, 2022

Study Completion (Actual)

May 26, 2022

Study Registration Dates

First Submitted

July 15, 2016

First Submitted That Met QC Criteria

August 31, 2016

First Posted (Estimated)

September 1, 2016

Study Record Updates

Last Update Posted (Actual)

March 5, 2026

Last Update Submitted That Met QC Criteria

March 4, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 2008-A01209-46

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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