Arterial pH Selectively Predicts Intensive Care Unit Transfer From the Emergency Department in Obese Patients With Acute Dyspnea

Arterial pH Selectively Predicts ICU Transfer in Obese Patients With Acute Dyspnea Presenting to the Emergency Department: a Prospective Comparative Cohort Study

This study evaluates the prognostic value of arterial blood gas analysis in a cohort of Emergency Department patients presenting with shortness of breath of any cause, comparing obese and non-obese patients.

Study Overview

• Status: Completed
• Conditions: Respiratory Failure; Dyspnea

Detailed Description

Factors associated with admission to intensive care unit (ICU) or ED mortality before transfer to the ICU are analyzed in obese (BMI ≥ 30kg.m-2) and non-obese patients subgroups.

• Study Type: Observational
• Enrollment (Actual): 400

Contacts and Locations

Study Locations

• France
  • Montpellier, France, 34295
    • Montpellier University Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Study population was derived from a cohort of adult patients admitted to the ED with acute dyspnea

Description

Inclusion Criteria:

• patients who presented with acute dyspnea in the ED
• patients who had an ABG analysis as part of the ED standard management

Exclusion Criteria:

• Patients with treatment limitation decisions made by the medical teams against ICU admission, including severe cognitive impairment or palliative care ,
• Patients with immediate transfer to ICU due to shock and hemodynamic instability at ED admission

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Composite of admission to the ICU or in ED mortality before ICU admission	Admission to the ICU following ED management will be at the discretion of the attending ICU physician, and in agreement with current guidelines for ICU admission, according to standard management	up to 1 day (direct admission to ICU from ED)

Collaborators and Investigators

• Sponsor: Association pour la Formation du Personnel à la Medecine d'Urgence
• Collaborators: University Hospital, Montpellier
• Investigators: Principal Investigator: Mustapha SEBBANE, MD, PhD, Emergency Department, University Hospital, Montpellier

Study record dates

Study Major Dates

• Study Start (Actual): May 23, 2013
• Primary Completion (Actual): May 30, 2014
• Study Completion (Actual): May 30, 2014

Study Registration Dates

• First Submitted: August 1, 2017
• First Submitted That Met QC Criteria: August 3, 2017
• First Posted (Actual): August 4, 2017

Study Record Updates

• Last Update Posted (Actual): August 4, 2017
• Last Update Submitted That Met QC Criteria: August 3, 2017
• Last Verified: August 1, 2017

More Information

Terms related to this study

• Keywords: Intensive care unit; emergency department; dyspnea; pH; blood gas analysis
• Additional Relevant MeSH Terms: Pathologic Processes; Respiratory Tract Diseases; Respiration Disorders; Disease Attributes; Signs and Symptoms, Respiratory; Emergencies; Respiratory Insufficiency; Dyspnea
• Other Study ID Numbers: pH acute dyspnea

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No