Epileptic Seizures in Intensive Care Units

June 1, 2022 updated by: University Hospital, Basel, Switzerland
This retrospective observational cohort study is to assess and analyze clinical, electroencephalographic, laboratory, comorbidity, and treatment characteristics of Intensive care unit (ICU)-patients with epileptic seizures and to subsequently compare their characteristics with ICU-patients with status epilepticus (SE).

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The aim of this retrospective observational cohort study is to get further insight into adult patients with epileptic seizures in ICUs in an academic tertiary medical care center regarding frequency, clinical and electroencephalogram (EEG) characteristics, treatment, course and outcome. This data could help understanding the epidemiology (including risk factors, influence of EEG), and to guide management and improve outcomes of affected patients.

Study Type

Observational

Enrollment (Actual)

200

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Switzerland
      • Basel, Switzerland, 4031
        • Clinic for Intensive Care Medicine, University Hospital Basel

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

All adult patients (i.e., ≥18 years of age) admitted to the ICUs at the University Hospital Basel that suffered from one or more epileptic seizures (detected clinically and/or by EEG) during their ICU-stay

Description

Inclusion Criteria:

  • admitted to the ICU at the University Hospital Basel
  • suffered from one or more epileptic seizures (detected clinically and/or by EEG) during their ICU-stay

Exclusion Criteria:

  • patients with epileptic seizures transforming into Status epilepticus (SE)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Frequency of epileptic seizures
Time Frame: between 01.01.2005 and 19.12.2018
Frequency of all epileptic seizures in the ICU
between 01.01.2005 and 19.12.2018

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Number of epileptic seizures captured by EEG
Time Frame: between 01.01.2005 and 19.12.2018
Number of epileptic seizures captured by EEG without overt clinical seizure presentation in the ICU
between 01.01.2005 and 19.12.2018
Number of epileptic seizures diagnosed on the basis of clinical symptoms alone
Time Frame: between 01.01.2005 and 19.12.2018
Number of epileptic seizures diagnosed on the basis of clinical symptoms alone in the ICU
between 01.01.2005 and 19.12.2018
Length of epileptic seizure (time)
Time Frame: between 01.01.2005 and 19.12.2018
Duration of epileptic seizure
between 01.01.2005 and 19.12.2018
Semiological feature of epileptic seizure (i.e. seizure types)
Time Frame: between 01.01.2005 and 19.12.2018
Semiological feature of epileptic seizure (i.e. seizure types) emerging in ICU-patients
between 01.01.2005 and 19.12.2018

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Basel, Switzerland

Investigators

  • Principal Investigator: Raoul Sutter, PD Dr. med, Clinic for Intensive Care Medicine, University Hospital Basel

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 1, 2019

Primary Completion (Actual)

April 30, 2022

Study Completion (Actual)

April 30, 2022

Study Registration Dates

First Submitted

February 26, 2019

First Submitted That Met QC Criteria

February 27, 2019

First Posted (Actual)

March 4, 2019

Study Record Updates

Last Update Posted (Actual)

June 2, 2022

Last Update Submitted That Met QC Criteria

June 1, 2022

Last Verified

June 1, 2022

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2018-02361; me19Sutter

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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