- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03933137
P-POSSUM Score and Length of Stay
Correlation Between P-POSSUM Score and Length of Stay in Kidney Transplant Recipients
Study Overview
Status
Conditions
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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DKI Jakarta
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Jakarta Pusat, DKI Jakarta, Indonesia, 10430
- Rumah Sakit Cipto Mangunkusumo
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Subjects are medical record of recipients who underwent kidney transplant
Exclusion Criteria:
- Medical record was incomplete
- Patients who died during surgery or before the patient was discharged.
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Retrospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
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Not prolonged length of stay
Living donor patients who had ≤ 6 days length of stay after laparoscopic nephrectomy procedure
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P-POSSUM score's variables are divided into physiological parameters (age, cardiac, respiratory, ECG, systolic blood pressure, pulse rate, haemoglobin, leukocyte count, urea, sodium plasma, potassium plasma, and GCS) and operative parameters (operation type, number of procedures, operative blood loss, peritoneal contamination, malignancy status, CEPOD).
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Prolonged length of stay
Living donor patients who had > 6 days length of stay after laparoscopic nephrectomy procedure
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P-POSSUM score's variables are divided into physiological parameters (age, cardiac, respiratory, ECG, systolic blood pressure, pulse rate, haemoglobin, leukocyte count, urea, sodium plasma, potassium plasma, and GCS) and operative parameters (operation type, number of procedures, operative blood loss, peritoneal contamination, malignancy status, CEPOD).
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Correlation between each variable of P-POSSUM and length of stay
Time Frame: 1 day before surgery until discharged from hospital, up to 30 days
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Correlation between 18 variables (12 variables as physical parameters and 6 variables as operative parameters) and length of stay
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1 day before surgery until discharged from hospital, up to 30 days
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P-POSSUM score Discrimination
Time Frame: 1 day before surgery until discharged from hospital, up to 30 days
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P-POSSUM score ability to discriminate length of stay based on variable scores: physical parameters and operative parameters
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1 day before surgery until discharged from hospital, up to 30 days
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P-POSSUM score Calibration
Time Frame: 1 day before surgery until discharged from hospital, up to 30 days
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P-POSSUM score cutoff to predict length of stay based on variable scores: physical parameters and operative parameters
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1 day before surgery until discharged from hospital, up to 30 days
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Patient's length of stay post kidney transplantation
Time Frame: From post surgery until discharged from hospital, up to 30 days
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Patient's length of stay post kidney transplantation
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From post surgery until discharged from hospital, up to 30 days
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P-POSSUM score (physical parameters): Age
Time Frame: 1 day before surgery
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The score for Age variable cut-off:
4 point >71 years |
1 day before surgery
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P-POSSUM score (physical parameters): Heart disease
Time Frame: 1 day before surgery
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The score for heart disease variable cut-off:
4 point for peripheral edema, warfarin, or borderline cardiomegaly on chest X-ray (CXR) |
1 day before surgery
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P-POSSUM score (physical parameters): Lung disease
Time Frame: 1 day before surgery
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The score for lung disease variable cut-off:
4 points for limiting dyspnea or moderate COPD on CXR 8 points for dyspnea at rest or fibrosis/consolidation on CXR |
1 day before surgery
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P-POSSUM score (physical parameters): ECG abnormality
Time Frame: 1 day before surgery
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The score for ECG abnormality variable cut-off: 1 point for normal ECG 4 points for atrial fibrillation (HR 60-90 8 points for 5 ectopic beats/min, Q waves or ST/T wave change |
1 day before surgery
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P-POSSUM score (physical parameters): Systolic blood pressure
Time Frame: 1 day before surgery
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The score for systolic blood pressure variable cut-off:
4 points for > 170 mmHg or 90-99 mmHg 8 points for < 90 mmHg |
1 day before surgery
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P-POSSUM score (physical parameters): Pulse rate
Time Frame: 1 day before surgery
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The score for pulse rate variable cut-off:
4 points for 101-120 bpm 8 points for > 121 bpm or < 40 bpm |
1 day before surgery
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P-POSSUM score (physical parameters): Hemoglobin
Time Frame: 1 day before surgery
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The score for hemoglobin variable cut-off:
4 points for 10-11.4 or 17.1-18 g/dL 8 points for <10 or >18 g/dL |
1 day before surgery
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P-POSSUM score (physical parameters): Leukocyte count
Time Frame: 1 day before surgery
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The score for leukocyte count variable cut-off:
4 points for >20.000 atau <3.000/mm3 |
1 day before surgery
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P-POSSUM score (physical parameters): Plasma potassium concentration
Time Frame: 1 day before surgery
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The score for plasma potassium concentration variable cut-off:
4 points for 2.9-3.1 or 5.4-5.9 mmol/L 8 points for <2.9 or >5.9 mmol/L |
1 day before surgery
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P-POSSUM score (physical parameters): Plasma sodium concentration
Time Frame: 1 day before surgery
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The score for plasma sodium concentration variable cut-off:
4 points for 126-130 mmol/L 8 points for <126 mmol/L |
1 day before surgery
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P-POSSUM score (operative parameters): Number of procedures
Time Frame: 1 day before surgery
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The score for number of procedures variable cut-off: 1 point for one 4 points for two 8 points for more than two |
1 day before surgery
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P-POSSUM score (operative parameters): Intraoperative blood loss
Time Frame: Intraoperative
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The score for intraoperative blood loss variable cut-off:
4 points for 501-999 mL 8 points for > 999 mL |
Intraoperative
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P-POSSUM score (operative parameters): Peritoneal contamination/soiling
Time Frame: Intraoperative
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The score for peritoneal contamination/soiling variable cut-off:
4 points for local pus 8 points for free bowel content, pus or blood |
Intraoperative
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P-POSSUM score (operative parameters): Presence of malignancy
Time Frame: 1 day before surgery
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The score for presence of malignancy variable cut-off:
4 points for nodal metastases 8 points for distant metastases |
1 day before surgery
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P-POSSUM score (operative parameters): Mode of surgery
Time Frame: 1 day before surgery
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The score for mode of surgery variable cut-off: 1 point for elective 4 points for emergency resuscitation of > 2 hours possible operation < 24 hours after admission 8 points for emergency (immediate surgery < 2 hours needed) |
1 day before surgery
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Collaborators and Investigators
Sponsor
Investigators
- Study Chair: Dita Aditianingsih, M.D, PhD, Department of Anesteshiology and Intensive Care, Cipto Mangunkusumo Hospital, Universitas Indonesia
Publications and helpful links
General Publications
- Reyna-Sepulveda F, Ponce-Escobedo A, Guevara-Charles A, Escobedo-Villarreal M, Perez-Rodriguez E, Munoz-Maldonado G, Hernandez-Guedea M. Outcomes and Surgical Complications in Kidney Transplantation. Int J Organ Transplant Med. 2017;8(2):78-84. Epub 2017 May 1.
- Howes TE, Cook TM, Corrigan LJ, Dalton SJ, Richards SK, Peden CJ. Postoperative morbidity survey, mortality and length of stay following emergency laparotomy. Anaesthesia. 2015 Sep;70(9):1020-7. doi: 10.1111/anae.12991. Epub 2015 Apr 15.
- McAdams-DeMarco MA, King EA, Luo X, Haugen C, DiBrito S, Shaffer A, Kucirka LM, Desai NM, Dagher NN, Lonze BE, Montgomery RA, Walston J, Segev DL. Frailty, Length of Stay, and Mortality in Kidney Transplant Recipients: A National Registry and Prospective Cohort Study. Ann Surg. 2017 Dec;266(6):1084-1090. doi: 10.1097/SLA.0000000000002025.
- Khambalia HA, Moinuddin Z, Summers AM, Tavakoli A, Pararajasingam R, Campbell T, Dhanda R, Forgacs B, Augustine T, van Dellen D. A prospective cohort study of risk prediction in simultaneous pancreas and kidney transplantation. Ann R Coll Surg Engl. 2015 Sep;97(6):445-50. doi: 10.1308/rcsann.2015.0001. Epub 2015 Aug 14.
- Grocott MP, Levett DZ, Matejowsky C, Emberton M, Mythen MG. ASA scores in the preoperative patient: feedback to clinicians can improve data quality. J Eval Clin Pract. 2007 Apr;13(2):318-9. doi: 10.1111/j.1365-2753.2006.00736.x. No abstract available.
- Chen T, Wang H, Wang H, Song Y, Li X, Wang J. POSSUM and P-POSSUM as predictors of postoperative morbidity and mortality in patients undergoing hepato-biliary-pancreatic surgery: a meta-analysis. Ann Surg Oncol. 2013 Aug;20(8):2501-10. doi: 10.1245/s10434-013-2893-x. Epub 2013 Feb 23.
- Moonesinghe SR, Mythen MG, Das P, Rowan KM, Grocott MP. Risk stratification tools for predicting morbidity and mortality in adult patients undergoing major surgery: qualitative systematic review. Anesthesiology. 2013 Oct;119(4):959-81. doi: 10.1097/ALN.0b013e3182a4e94d.
- Baron DM, Hochrieser H, Posch M, Metnitz B, Rhodes A, Moreno RP, Pearse RM, Metnitz P; European Surgical Outcomes Study (EuSOS) group for Trials Groups of European Society of Intensive Care Medicine; European Society of Anaesthesiology. Preoperative anaemia is associated with poor clinical outcome in non-cardiac surgery patients. Br J Anaesth. 2014 Sep;113(3):416-23. doi: 10.1093/bja/aeu098. Epub 2014 May 14.
- Li S, Zhou K, Lai Y, Shen C, Wu Y, Che G. Estimated intraoperative blood loss correlates with postoperative cardiopulmonary complications and length of stay in patients undergoing video-assisted thoracoscopic lung cancer lobectomy: a retrospective cohort study. BMC Surg. 2018 May 23;18(1):29. doi: 10.1186/s12893-018-0360-0.
- Amer MS, Hamza SA, Wahba HMF, Barakat DB. Effects of Anemia on The Outcome in Elderly Admitted to The ICU. Indian J Med Res Pharm Sci. 2016;3(April):27-32.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- IndonesiaUAnes034
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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