- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04191473
Comparison of EMR-P With Conventional EMR
Comparison of Precutting vs Conventional Endoscopic Mucosal Resection of Intermediate-Size Colorectal Polyps
Colorectal cancer is the third most common cancer in men and the second most common cancer in women.There are about 14 million cases of colonoscopy in the United States every year. In recent years, the incidence of colorectal cancer in China has risen sharply, becoming a serious threat to people's health.For small(≤ 9mm) lesions, endoscopic biopsy forceps and cold snare polypectomy can be used to remove.For larger lesions, especially laterally spreading tumor,endoscopic mucosal resection is a classic method of treatment.With the increasing diameter of the lesion size(> 20mm),we also need to adopt endoscopic piecemeal mucosal resection or endoscopic submucosal dissection.
As IT, Hook knife, BB, and other devices appear constantly, foreign researchers recently adopted a variation of conventional EMR(CEMR), namely endoscopic mucosal resection with circumferential precutting(EMR - P).The technology is superior to conventional EMR for 10 to 20 mm polyps.Moreover, preliminary studies suggest that it has good safety and efficacy, and may be a better method for treatment of 10-20mm polyps under colonoscopy.
This clinical trial is being conducted to compare the efficacy and safety of two methods of polypectomy, CEMR and EMR-P, for 10-20mm colorectal polyps.
Study Overview
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Chaohui Yu, PhD
- Phone Number: +8613957161659
- Email: ych623@sina.com
Study Locations
-
-
Zhejiang
-
Hangzhou, Zhejiang, China
- Recruiting
- The First Affiliated Hospital of Zhejiang University
-
Contact:
- Chaohui Yu, PhD
-
Jinhua, Zhejiang, China
- Recruiting
- Jinhua Municipal Central Hospital
-
Contact:
- Xiaoyun Yang, MD
-
Lishui, Zhejiang, China
- Recruiting
- The Central Hospital of Lishui City
-
Contact:
- Bin Ye, PhD
-
Ningbo, Zhejiang, China
- Recruiting
- Ningbo First Hospital
-
Contact:
- Lei Xu, PhD
-
Ningbo, Zhejiang, China
- Recruiting
- Ningbo Medical Center Lihuili Hospital
-
Contact:
- Yufei Song, BD
-
Taizhou, Zhejiang, China
- Recruiting
- Taizhou Hospital of Zhejiang Province
-
Contact:
- Xinli Mao, PhD
-
Yuyao, Zhejiang, China
- Recruiting
- Renmin Hospital of Yuyao City
-
Contact:
- Jianbo Zhou, BD
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- One polyp or lesion of 10-20mm at the most proximal of colorectal
- Adult patients (≥18 years old)
- Polyps other than pedicled polyps
Exclusion Criteria:
- There was submucosal infiltration under endoscope
- Residual lesions after endoscopic resection
- Inflammatory bowel disease, familial polyps, electrolyte abnormalities, coagulation disorders, or severe organ failure
- Pregnant or nursing
- No informed consent has been signed
- Patients taking NSAIDs or other anticoagulants
- sedated colonoscopy
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: group P
|
After submucosal injection, we use ESD knife or the tip of the entrapment device to loop around the lesion, and then overlapped the loop tangent with the entrapment device.
After tightening the entrapment device, all the tumor tissues were confirmed to enter the entrapment device, and the tissues were removed.
|
Other: group C
|
A liquid pad was formed by injecting 0.9% normal saline with meilan solution into submucosa,and then overlapped the loop tangent with the entrapment device.
After tightening the entrapment device, all the tumor tissues were confirmed to enter the entrapment device, and the tissues were removed.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
R0 rate
Time Frame: 7 days
|
en bloc resection with a histologically confirmed negative resection margin
|
7 days
|
En bloc rate
Time Frame: immediately
|
endoscopically assessed removal of the lesion in one piece
|
immediately
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- V2.0
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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