End-tidal Carbon Dioxide Monitoring in Low Tidal Volume Ventilation (ETCO2)

Does End-Tidal Carbon Dioxide Value Show The Adequacy Of Ventilation In Low Tidal Volume Ventilation

In cases where there is no ventilation-perfusion problem, the end-tidal carbon dioxide (ETCO2) value is closely associated with partial arterial carbon dioxide pressure (PaCO2); therefore, the PaCO2 value can be estimated using ETCO2 measurements in patients without significant cardiopulmonary disorders. The aim of the investigator's study is to evaluate the reliability of pulmonary ventilation monitoring with ETCO2 value and to investigate at what tidal volume values ETCO2 monitoring provides reliable information.

Study Overview

• Status: Completed
• Conditions: Ventilation; End-Tidal Carbon Dioxide
• Intervention / Treatment: Other: if the ventilation parameter caused desaturation or hypercapnia we will change the parameter

Detailed Description

The patients were grouped as follows: Group 1, if the tidal volume is 4 ml/kg; Group 2, if TV=6 ml/kg; Group 3, if TV=8 ml/kg; and Group 4, if TV=10 ml/kg. It was determined how many breaths per minute (minute ventilation) would be given with tidal volume x respiratory rate=6 L. The patients were ventilated with the same ventilation parameters for 30 minutes and then arterial blood gas analysis was performed. Arterial blood gas was collected at t1 for group 1, t2 for group 2, t3 for group 3, and t4 for group 4. The ETCO2 value, Peak pressure (Ppeak), Plateau pressure (Pplato), mean airway pressure (Pmean) values were recorded at the time of arterial blood gas collection. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), peak heart rate (PHR) values were evaluated. The patients with a mean arterial pressure of less than 65 mmHg were excluded from the study. Partial arterial oxygen pressure (PaO2), partial arterial carbon dioxide pressure (PaCO2), oxygen saturation (SO2) values were recorded from the arterial blood gas analysis. P (a-ET) CO2 gradient value was calculated.

The groups were compared, in each patient, under the same conditions, when the different tidal volume was applied, how the ETCO2 monitorization, PaO2 values and hence the P (a-ET) CO2 gradient changed.

• Study Type: Interventional
• Enrollment (Actual): 50
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Turkey
  • Istanbul, Turkey
    • Istanbul, Istanbul, Turkey, Turkey, 34000
      • Döndü Genç Moralar

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 65 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

American Society of Anesthesiologists (ASA) classification 1, 2 risk group

Head and neck surgery under general anesthesia lasting more than 120 minutes and who progressed normotensive.

Exclusion Criteria:

Cardiac disease

Pulmonary disease

Obese patients

Study Plan

How is the study designed?

Design Details

• Primary Purpose: OTHER
• Allocation: RANDOMIZED
• Interventional Model: SEQUENTIAL
• Masking: TRIPLE

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: Group 1; tidal volüm is 4 ml/kg	Other: if the ventilation parameter caused desaturation or hypercapnia we will change the parameter; we will increased fi02
EXPERIMENTAL: Group 2; tidal volüm is 6 ml/kg	Other: if the ventilation parameter caused desaturation or hypercapnia we will change the parameter; we will increased fi02
EXPERIMENTAL: Group 3; tidal volüm is 8 ml/kg	Other: if the ventilation parameter caused desaturation or hypercapnia we will change the parameter; we will increased fi02
EXPERIMENTAL: Group 4; tidal volüm is 10 ml/kg	Other: if the ventilation parameter caused desaturation or hypercapnia we will change the parameter; we will increased fi02

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
P (a-ET) CO2 gradient	The groups were compared, in each patient, under the same conditions, when the different tidal volume was applied, how the ETCO2 monitorization, PaCO2 values and hence the P (a-ET) CO2 gradient changed.	120 minutes

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Partial arterial oxygen pressure (PaO2)	Partial arterial oxygen pressure (PaO2) were recorded from the arterial blood gas analysis	120 minutes

Collaborators and Investigators

• Sponsor: Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Study record dates

Study Major Dates

• Study Start (ACTUAL): May 7, 2019
• Primary Completion (ACTUAL): January 23, 2020
• Study Completion (ACTUAL): January 23, 2020

Study Registration Dates

• First Submitted: February 17, 2020
• First Submitted That Met QC Criteria: February 21, 2020
• First Posted (ACTUAL): February 24, 2020

Study Record Updates

• Last Update Posted (ACTUAL): February 24, 2020
• Last Update Submitted That Met QC Criteria: February 21, 2020
• Last Verified: February 1, 2020

More Information

Terms related to this study

• Keywords: ETCO2; End-Tidal Carbon Dioxide; P(a-ET)CO2 gradient; low tidal volüm; mekanical Ventilation
• Other Study ID Numbers: dondum

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No