European/Euro-ELSO Survey on Adult and Neonatal/ Pediatric COVID-19 Patients in ECMO (EuroECMO-COVID)

European/Euro-ELSO Survey on Adult and Neonatal/ Pediatric COVID Patients in ECMO

In the last 10 years, severe acute respiratory infection (SARI) was responsible of multiple outbreaks putting a strain on the public health worldwide. Indeed, SARI had a relevant role in the development of pandemic and epidemic with terrible consequences such as the 2009 H1N1 pandemic which led to more than 200.000 respiratory deaths globally.

In late December 2019, in Wuhan, Hubei, China, a new respiratory syndrome emerged with clinical signs of viral pneumonia and person-to-person transmission. Tests showed the appearance of a novel coronavirus, namely the 2019 novel coronavirus (COVID-19). Two other strains, the severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) have caused severe respiratory illnesses, sometimes fatal. In particular, the mortality rate associated with SARS-CoV and MERS-CoV, was of 10% and 37% respectively.

Even though COVID-19 appeared from the first time in China, quickly it spread worldwide and cases have been described in other countries such as Thailand, Japan, South Korea, Germany, Italy, France, Iran, USA and many other countries. An early paper reported 41 patients with laboratory-confirmed COVID-19 infection in Wuhan. The median age of the patients was 49 years and mostly men (73%). Among those, 32% were admitted to the ICU because of the severe hypoxemia. The most associated comorbidities were diabetes (20%), hypertension (15%), and cardiovascular diseases (15%). On admission, 98% of the patients had bilateral multiple lobular and sub-segmental areas of consolidation. Importantly, acute respiratory distress syndrome (ARDS) developed in 29% of the patients, while acute cardiac injury in 12%, and secondary infection in 10%. Invasive mechanical ventilation was required in 10% of those patients, and two of these patients (5%) had refractory hypoxemia and received extracorporeal membrane oxygenation (ECMO). In a later retrospective report by Wang and collaborators, clinical characteristics of 138 patients with COVID-19 infection were described. ICU admission was required in 26.1% of the patients for acute respiratory distress syndrome (61.1%), arrhythmia (44.4%), and shock (30.6%). ECMO support was needed in 11% of the patients admitted to the ICU. During the period of follow-up, overall mortality was 4.3%.

The use of ECMO in COVID-19 infection is increasing due to the high transmission rate of the infection and the respiratory-related mortality.

Therefore, the investigators believe that ECMO in case of severe interstitial pneumonia caused by COVID could represent a valid solution in order to avoid lung injuries related to prolonged treatment with non-invasive and invasive mechanical ventilation. In addition, ECMO could have a role for the systemic complications such as septic and cardiogenic shock as well myocarditis scenarios. Potential clinical effects and outcomes of the ECMO support in the novel coronavirus pandemic will be recorded and analyzed in our project.

The researchers hypothesize that a significant percentage of patients with COVID-19 infection will require the utilize of ECMO for refactory hypoxemia, cardiogenic shock or septic shock. This study seeks to prove this hypothesis by conducting an observational retrospective/prospective study of patients in the ICU who underwent ECMO support and describe clinical features, severity of pulmonary dysfunction and risk factors of COVID-patients who need ECMO support, the incidence of ECMO use, ECMO technical characteristics, duration of ECMO, complications and outcomes of COVID-patients requiring ECMO support.

Study Overview

• Status: Recruiting
• Conditions: Septic Shock; Extracorporeal Membrane Oxygenation; COVID; SARS-CoV-2; Cardiogenic Shock; ARDS, Human; Refractory Hypoxemia

• Study Type: Observational
• Enrollment (Anticipated): 150

Contacts and Locations

• Study Contact: Name: Lorusso, Prof. Dr.; Phone Number: + 31(0) 433877095; Email: roberto.lorussobs@gmail.com

Study Locations

• Austria
  • Innsbruck, Austria
    • Recruiting
    • Universitätskliniken Innsbruck
    • Contact: Nikolaos Bonaros, Prof.
    • Contact: Christoph Krapf, Dr.
  • St.Pölten, Austria
    • Recruiting
    • Landesklinikum Sankt Pölten
    • Contact: Nikolaos Bonaros, Prof.
  • Vienna, Austria
    • Recruiting
    • Medical University of Vienna
    • Contact: Peter Schellongowski, Dr.
• Belgium
  • Aalst, Belgium
    • Recruiting
    • Onze Lieve Vrouwziekenhuis Aalst
    • Contact: Bernard Stockman, Dr.
  • Antwerp, Belgium
    • Recruiting
    • University Hospital, Antwerp
    • Contact: Gerdy Debeuckelaere
  • Brussel, Belgium
    • Recruiting
    • Erasme University Hospital
    • Contact: Fabio Taccone, Prof.
  • Brussel, Belgium
    • Recruiting
    • Universitair Ziekenhuis Brussel
    • Contact: Dimitri Vandeweghe
  • Brussels, Belgium
    • Recruiting
    • Centre Hospitalier Universitaire Saint Pierre
    • Contact: Olivier Germay
  • Brussels, Belgium
    • Recruiting
    • CHIREC
    • Contact: Daniel De Backer, Dr.
  • Charleroi, Belgium
    • Recruiting
    • Hôpital Civil Marie Curie de Charleroi
    • Contact: Patrick Biston, Dr.
    • Contact: Michael Piagnerelli
  • Ghent, Belgium
    • Recruiting
    • University Hospital, Ghent
    • Contact: Harlinde Peperstraete
  • La Louvière, Belgium
    • Recruiting
    • La Louvière Hopital
    • Contact: Romain Courcelle
  • Leuven, Belgium
    • Recruiting
    • Universitaire Ziekenhuizen Leuven
    • Contact: Leen Vercaemst, Dr.
  • Liège, Belgium
    • Recruiting
    • CHU de Liege
    • Contact: Marc Lagny
• Czechia
  • Praha, Czechia
    • Recruiting
    • Charles University, Czech Republic
    • Contact: Vaclav Vobruba
  • Praha, Czechia
    • Recruiting
    • General University Hospital, Prague
    • Contact: Jan Belohlavek, Prof.
• Denmark
  • Copenhagen, Denmark
    • Recruiting
    • Copenhagen University Hospital at Herlev
    • Contact: Finn Moeller Pedersen, Dr.
• France
  • Bourdeaux, France
    • Recruiting
    • University Hospital, Bordeaux
    • Contact: Olivier Brissaud
  • Lyon, France
    • Recruiting
    • Hospices Civils de Lyon
    • Contact: Matteo Pozzi, Dr.
  • Montpellier, France
    • Recruiting
    • University Hospital, Montpellier
    • Contact: Phillipe Gaudard
  • Paris, France
    • Recruiting
    • Pitie-Salpêtrière Hospital
    • Contact: Alain Combes, Prof.
    • Contact: Thierry Folliguet, Prof.
  • Paris, France
    • Recruiting
    • Henri Mondor University Hospital
    • Contact: Gabriel Saiydoun, Dr.
  • Paris, France
    • Recruiting
    • Paris South University Hospitals
    • Contact: Pierre Tissieres
  • Rennes, France
    • Recruiting
    • Rennes University Hospital
    • Contact: Alessandro Paradiso, Dr.
• Germany
  • Aachen, Germany
    • Recruiting
    • University Hospital, Aachen
    • Contact: Alexander Kersten, Dr.
  • Berlin, Germany
    • Recruiting
    • German Heart Center
    • Contact: Felix Hennig, Dr.
  • Düsseldorf, Germany
    • Recruiting
    • Universitätsklinikum Düsseldorf
    • Contact: Udo Boeken, Prof.
  • Essen, Germany
    • Recruiting
    • Children's Medical Hospital, University of Essen, Essen, Germany
    • Contact: Malaika Mendoca
  • Essen, Germany
    • Recruiting
    • University Hospital, Essen
    • Contact: Matthias Thielman, Prof.
  • Freiburg, Germany
    • Recruiting
    • University Heart Center Freiburg - Bad Krozingen
    • Contact: David Schibilsky, Dr.
    • Contact: Sven Maier, Dr.
  • Hannover, Germany
    • Recruiting
    • Hannover Medical School
    • Contact: Jan Schmitto, Prof.
    • Contact: Christian Napp, Dr.
  • Kassel, Germany
    • Recruiting
    • Klinikum Kassel
    • Contact: Ralf Muellenbach, Prof
    • Contact: Torje Iuliu, Dr.
  • Köln, Germany
    • Recruiting
    • Universitätsklinikum Köln
    • Contact: Simone Schafer, Dr.
  • Leipzig, Germany
    • Recruiting
    • Heart Center Leipzig - University Hospital
    • Contact: Diyar Saeed, Prof.
  • Nürnberg, Germany
    • Recruiting
    • Klinikum Nürnberg
    • Contact: Justyna Swol, Dr.
  • Regensburg, Germany
    • Recruiting
    • University Hospital Regensburg
    • Contact: Maximillian Malfertheiner, Dr.
    • Contact: Esther Dreier, Dr.
  • Tuebingen, Germany
    • Recruiting
    • University Hospital Tuebingen
    • Contact: Philipp Hen, Dr.
    • Contact: Aron Frederik Popov, Prof.
• Greece
  • Alexandroupolis, Greece
    • Recruiting
    • University Hospital, Alexandroupolis
    • Contact: Dimitrios Soufleris
• Hungary
  • Budapest, Hungary
    • Recruiting
    • Heim Pal Children's Hospital
    • Contact: Veronika Maraczi
• Israel
  • Jerusalem, Israel
    • Recruiting
    • ECMO Centers Israel
    • Contact: Maged Makhoul, Dr.
    • Contact: Gil Bolotin, Dr.
• Italy
  • Alessandria, Italy
    • Recruiting
    • San Giorgio Clinic
    • Contact: Sandrelli Luca, Dr.
  • Ancona, Italy
    • Recruiting
    • Ospedali Riuniti Ancona
    • Contact: Roberto Carozza
  • Bergamo, Italy
    • Recruiting
    • Papa Giovanni XXIII Hospital
    • Contact: Davide Ghitti, Dr.
  • Bologna, Italy
    • Recruiting
    • St. Orsola Hospital
    • Contact: Antonio Loforte, Dr.
  • Brescia, Italy
    • Recruiting
    • Azienda Ospedaliera Spedali Civili di Brescia
    • Contact: Giovanni Chiarini, Dr.
  • Cesena, Italy
    • Recruiting
    • Ospedale Maurizio Bufalini
    • Contact: Allesandro Circelli, Dr.
  • Genua, Italy
    • Recruiting
    • Gaslini Children's Hospital
    • Contact: Andrea Moscatelli
  • Massa, Italy
    • Recruiting
    • G. Pasquinucci Heart Hospital, Massa
    • Contact: Paolo Del Sarto
  • Milan, Italy
    • Recruiting
    • Niguarda Hospital
    • Contact: Paolof Meani, Dr.
    • Contact: Antioco Cappai, Dr.
  • Milan, Italy
    • Recruiting
    • Ospedale San Donato
    • Contact: Dario Fina, Dr.
    • Contact: Marco Ranucci, Dr.
  • Milan, Italy
    • Recruiting
    • San Raffaele University Hospital, Italy
    • Contact: Giovenni Landoni
    • Contact: Mara Scandroglio
  • Milano, Italy
    • Recruiting
    • Policlinico Hospital Milan
    • Contact: Giacomo Cavallaro
  • Monza, Italy
    • Recruiting
    • San Gerardo Hospital
    • Contact: Marco Giani, Dr.
    • Contact: Roberto Rona, Dr.
  • Pavia, Italy
    • Recruiting
    • IRCCS Policlinico S. Matteo
    • Contact: Mirko Belliato, Dr.
    • Contact: Antonella Degani
  • Puglia, Italy
    • Recruiting
    • GVM Care & Research
    • Contact: Ignazio Condello
    • Contact: Marco Moscarelli, Dr.
  • Roma, Italy
    • Recruiting
    • Bambino Gesù Hospital and Research Institute
    • Contact: Matteo Di Nardo
  • Roma, Italy
    • Recruiting
    • San Camillo Hospital, Rome
    • Contact: Andrea Montalto, Dr.
  • Turin, Italy
    • Recruiting
    • A.O.U. Città della Salute e della Scienza - Molinette Hospital
    • Contact: Vito Fanelli, Dr.
  • Turin, Italy
    • Recruiting
    • Mauriziano Umberto I Hospital
    • Contact: Maria Elena De Piero, Dr.
  • Turin, Italy
    • Recruiting
    • Ospedale S. Giovanni Bosco
    • Contact: Maria Elena De Piero, Dr.
  • Udine, Italy
    • Recruiting
    • University Hospital, Udine, Italy
    • Contact: Sandro Sponga, Dr.
  • Venice, Italy
    • Recruiting
    • Ospedale dell'Angelo, Venezia-Mestre
    • Contact: Reina Gianfranco, Dr.
  • Vicenza, Italy
    • Recruiting
    • Ospedale San Bortolo di Vicenza
    • Contact: Marco Piccichè
• Lithuania
  • Vilnius, Lithuania
    • Recruiting
    • Vilnius University hospital Santaros klinikos
    • Contact: Robertas Samalavicius, Dr.
• Netherlands
  • Groningen, Netherlands
    • Recruiting
    • University of Groningen
    • Contact: Martin Kneyber
  • Leiden, Netherlands
    • Recruiting
    • Leiden University Medical Center
    • Contact: Dario Candura, Dr.
    • Contact: Jacinta Maas, Dr.
  • Maastricht, Netherlands
    • Recruiting
    • Maastricht University Medical Center
    • Contact: Lorusso, Prof. Dr.
    • Sub-Investigator: Lo Coco, Drs.
    • Sub-Investigator: De Piero, Drs.
  • Rotterdam, Netherlands
    • Recruiting
    • Erasmus Medical Center
    • Contact: Dinis Reis Miranda, Dr.
  • Utrecht, Netherlands
    • Recruiting
    • UMC Utrecht
    • Contact: J.J. van der Heijden, Dr.
• Poland
  • Warsaw, Poland
    • Recruiting
    • Medical University of Warsaw
    • Contact: Mariusz Kowaleswsky, Dr.
• Portugal
  • Porto, Portugal
    • Recruiting
    • Hospital Sao Joao
    • Contact: Luis Filipe Pinto, Dr.
• Russian Federation
  • Chelyabinsk, Russian Federation
    • Recruiting
    • Chelyabinsk Regional Clinical Hospital
    • Contact: Alexandr Turchaninov
  • Ekaterinburg, Russian Federation
    • Recruiting
    • City Hospital No 41, Ekaterinburg, Russia
    • Contact: Alexandr Turchaninov
  • Kemerovo, Russian Federation
    • Recruiting
    • Kemerovo Regional Clinical Cardiological Center named after academician L.S. Barbarash
    • Contact: Roman Komelyuk
  • Krasnodar, Russian Federation
    • Recruiting
    • Krasnodar Regional Hospital no 1
    • Contact: Alexander Skopets
  • Moscow, Russian Federation
    • Recruiting
    • City Clinical Hospital No. 67, Moscow, Russia
    • Contact: Ivan Akufov
    • Contact: Alexandra Shilova
  • Novosibirsk, Russian Federation
    • Recruiting
    • Novosibirsk City Hospital #2
    • Contact: Igor Komilov
  • Saint Petersburg, Russian Federation
    • Recruiting
    • City Hospital No 40, Saint Petersburg, Russia
    • Contact: Daniil Shelukhin
    • Contact: Sergei Minin
• Spain
  • Barcelona, Spain
    • Recruiting
    • Hospital Sant Joan de Deu
    • Contact: Susana Segura Matute
  • Barcelona, Spain
    • Recruiting
    • Hospital Vall d'Hebron
    • Contact: Jordi Riero del Brio, Dr.
  • Madrid, Spain
    • Recruiting
    • Hospital Universitario Ramon y Cajal
    • Contact: Aaron Blandino, Ortiz
  • Zaragoza, Spain
    • Recruiting
    • Hospital Miguel Servet
    • Contact: Pablo Ruiz, Dr.
• Sweden
  • Lund, Sweden
    • Recruiting
    • Lund University Hospital
    • Contact: Edgars Grins
  • Stockholm, Sweden
    • Recruiting
    • Karolinska University Hospital
    • Contact: Lars Broman, Dr.
• Switzerland
  • Basel, Switzerland
    • Recruiting
    • University Hospital, Basel, Switzerland
    • Contact: Thomas Doebele
  • Bern, Switzerland
    • Recruiting
    • University of Bern
    • Contact: Jolanda Consiglio
    • Contact: Jenni Hansjoerg
  • Geneva, Switzerland
    • Recruiting
    • University Hospital, Geneva
    • Contact: Angelo Polito
  • Lausanne, Switzerland
    • Recruiting
    • University of Lausanne Hospitals
    • Contact: Xavier Bechtold
  • Lugano, Switzerland
    • Recruiting
    • Cardiocentro Ticino
    • Contact: Gianluca Agus, Dr.
  • Zürich, Switzerland
    • Recruiting
    • Klinik Hirslanden, Zurich
    • Contact: Halbe Maximillian, Dr.
  • Zürich, Switzerland
    • Recruiting
    • University of Zurich
    • Contact: Alberto Weber, Prof. Dr.
    • Contact: Grünenfelder Jürg, Prof. Dr.
• United Kingdom
  • Brompton, United Kingdom
    • Recruiting
    • Royal Brompton & Harefield NHS Foundation Trust
    • Contact: Verna Aquino
  • Glasgow, United Kingdom
    • Recruiting
    • Paediatric Intensive Care Glasgow
    • Contact: Mark Davidson
  • Leicester, United Kingdom
    • Recruiting
    • Leicester Children's Hospital
    • Contact: Claire Westrope
  • London, United Kingdom
    • Recruiting
    • Guy's and St Thomas' NHS Foundation Trust
    • Contact: Nicholas Bartlett, Dr.
  • London, United Kingdom
    • Recruiting
    • Great Ormond Street Hospital For Children NHS Foundation Trust
    • Contact: Katherine Brown
  • Newcastle Upon Tyne, United Kingdom
    • Recruiting
    • Newcastle-upon-Tyne Hospitals NHS Trust
    • Contact: Judit Llevadias

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

patients with confirmed COVID-19 infection who require ECMO support

Description

Inclusion Criteria:

• Laboratory-confirmed COVID-19 infection by real-time PCR (polymerase chain reaction)
• ECMO for treatment severe lung disease COVID-19 related

Exclusion Criteria:

• Patients treated with ECMO for other concomitant causes.

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Age	age in years	at baseline
Gender	male/female	at baseline
Weight	in kilograms	at baseline
Height	in meters	at baseline
BMI	weight and height combined to calculate BMI in kg/m^2	at baseline
Pre-existing pulmonary disease y/n	Asthma y/n, cystic fibrosis y/n, chronic obstructive pulmonary disease y/n, pulmonary hypertension y/n, pulmonary fibrosis y/n, chronic restrictive lung disease y/n	at baseline
Main co-morbidities y/n	diabetes mellitus y/n, chronic renal failure y/n, ischemic heart disease y/n, heart failure y/n, chronic liver failure y/n, neurological impairment y/n	at baseline
Date of signs of COVID-19 infection	in dd-mm-yyyy or mm-dd-yyyy	at baseline or date of occurence
Date of positive swab	in dd-mm-yyyy or mm-dd-yyyy	at baseline or date of occurence
Pre-ECMO length of hospital stay	in days	at or during ECMO-implant
Pre-ECMO length of ICU stay	in days	at or during ECMO-implant
Pre-ECMO length of mechanical ventilation days	in days	at or during ECMO-implant
Use of antibiotics	y/n, what kind	up to 6 months
Use of anti-viral treatment	y/n, what kind	up to 6 months
Use of second line treatment	y/n, what kind (eg prone-position, recruitment manoeuvers, neuromuscular blockade etc)	up to 6 months
Indications for ECMO-implant	respiratory or cardiac	at ECMO-implant
Type of ECMO-implant	veno-venous, veno-arterial or veno-venoarterial	at ECMO-implant
Type of access	peripheral or central	at ECMO-implant
Date of ECMO implant	in dd-mm-yyyy or mm-dd-yyyy	at ECMO-implant
ECMO blood flow rate	l/min	from day of ECMO-implant for every 24 hours until date of weaning or death, up to 6 months
ECMO gas flow rate	l/min	from day of ECMO-implant for every 24 hours until date of weaning or death, up to 6 months
ECMO configuration change	y/n	up to 6 months
Date of ECMO configuration change	in dd-mm-yyyy or mm-dd-yyyy	up to 6 months
New ECMO configuration	veno-venous, veno-arterial, veno-venoarterial, other	up to 6 months
Indications for ECMO configuration change	right ventricular failure, left ventricular failure, refractory hypoxemia	up to 6 months
Ventilator setting on ECMO	settings of ventilator	from day of ECMO-implant for every 24 hours until date of weaning or death, up to 6 months
Anticoagulation during ECMO	heparin, bivalirudin, nothing	from day of ECMO-implant for every 24 hours until date of weaning or death, up to 6 months
Frequency of ECMO circuit change	amount of ECMO circuit changes (1, 2, 3 etc.)	up to 6 months
ECMO complications	Hemorrhagic, infection, other complications	up to 6 months
ECMO Weaning	y/n	from day of ECMO-implant for every 24 hours until date of weaning or death, up to 6 months
ICU discharge	y/n, date	from day of ICU-admission for every 24 hours until date of discharge or death, up to 6 months
Main cause of death		6 months
Type of discharge	Ward, another ICU, rehabilitation center, home	up to 6 months
Alive/deceased		6 months

Collaborators and Investigators

• Sponsor: Maastricht University Medical Center
• Collaborators: Charles University, Czech Republic; Karolinska University Hospital; Hospices Civils de Lyon; IRCCS Azienda Ospedaliero-Universitaria di Bologna; Medical University of Vienna; University of Zurich; University Hospital, Geneva; Universitaire Ziekenhuizen KU Leuven; Hannover Medical School; University Hospital, Essen; University Hospital, Montpellier; UMC Utrecht; Erasmus Medical Center; University Hospital, Basel, Switzerland; Bambino Gesù Hospital and Research Institute; University Hospital, Bordeaux; Guy's and St Thomas' NHS Foundation Trust; Copenhagen University Hospital at Herlev; Ospedale San Donato; University Hospital, Ghent; Universitair Ziekenhuis Brussel; University Hospital, Antwerp; Rennes University Hospital; University of Lausanne Hospitals; University of Bern; Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia; Niguarda Hospital; Hospital Universitario Ramon y Cajal; University Hospital Tuebingen; Royal Brompton & Harefield NHS Foundation Trust; Leiden University Medical Center; Newcastle-upon-Tyne Hospitals NHS Trust; Klinikum Kassel; Medical University of Warsaw; Lund University Hospital; Great Ormond Street Hospital for Children NHS Foundation Trust; IRCCS Policlinico S. Matteo; San Gerardo Hospital; Heart Center Leipzig - University Hospital; Erasme University Hospital; Henri Mondor University Hospital; University of Groningen; Pitié-Salpêtrière Hospital; General University Hospital, Prague; Hospital Vall d'Hebron; Centre Hospitalier Universitaire Saint Pierre; Cardiocentro Ticino; Klinikum Nürnberg; Klinik Hirslanden, Zurich; Hospital Miguel Servet; Centre Hospitalier Universitaire de Liege; University Hospital Regensburg; City Hospital No 41, Ekaterinburg, Russia; University Hospital, Aachen; Onze Lieve Vrouwziekenhuis Aalst; University Hospital, Udine, Italy; Universitätsklinikum Köln; Landesklinikum Sankt Polten; Hospital Sant Joan de Deu; Vilnius University Hospital Santaros Klinikos; City Hospital No 40, Saint Petersburg, Russia; San Raffaele University Hospital, Italy; Papa Giovanni XXIII Hospital; San Camillo Hospital, Rome; Ospedale S. Giovanni Bosco; The Mediterranean Institute for Transplantation and Advanced Specialized Therapies; Hospital Sao Joao; Ospedali Riuniti Ancona; A.O.U. Città della Salute e della Scienza - Molinette Hospital; Ospedale San Bortolo di Vicenza; Gaslini Children's Hospital; Heim Pal Children's Hospital; Ospedale dell'Angelo, Venezia-Mestre; University Heart Center Freiburg - Bad Krozingen; University Hospital, Alexandroupolis; European chapter of the Extracorporeal Life Support Organization; San Giorgio Clinic; GVM Care & Research; Universitätsklinikum Düsseldorf; German Heart Center; Hôpital Civil Marie Curie de Charleroi; Universitätskliniken Innsbruck; Novosibirsk City Hospital #2; City Clinical Hospital No. 67, Moscow, Russia; Krasnodar Regional Hospital no 1; Kemerovo Regional Clinical Cardiological Center named after academician L.S. Barbarash; G. Pasquinucci Heart Hospital, Massa; Policlinico Hospital Milan; Children's Medical Hospital, University of Essen, Essen, Germany; Paediatric Intensive Care Glasgow; Paris South University Hospitals; Chelyabinsk Regional Clinical Hospital; ECMO Centers Israel; Ospedale M. Bufalini Cesena; Mauriziano Umberto I Hospital; Chirec; La Louvière Hopital; Leicester Royal Infirmary NHS Trust
• Investigators: Principal Investigator: Lorusso, Prof. Dr., Maastricht University Hospital

Publications and helpful links

General Publications

• Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24. Erratum In: Lancet. 2020 Jan 30;:
• Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, Xing F, Liu J, Yip CC, Poon RW, Tsoi HW, Lo SK, Chan KH, Poon VK, Chan WM, Ip JD, Cai JP, Cheng VC, Chen H, Hui CK, Yuen KY. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020 Feb 15;395(10223):514-523. doi: 10.1016/S0140-6736(20)30154-9. Epub 2020 Jan 24.
• Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y, Li Y, Wang X, Peng Z. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020 Mar 17;323(11):1061-1069. doi: 10.1001/jama.2020.1585. Erratum In: JAMA. 2021 Mar 16;325(11):1113.
• Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012 Nov 8;367(19):1814-20. doi: 10.1056/NEJMoa1211721. Epub 2012 Oct 17. Erratum In: N Engl J Med. 2013 Jul 25;369(4):394.
• Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, Spitters C, Ericson K, Wilkerson S, Tural A, Diaz G, Cohn A, Fox L, Patel A, Gerber SI, Kim L, Tong S, Lu X, Lindstrom S, Pallansch MA, Weldon WC, Biggs HM, Uyeki TM, Pillai SK; Washington State 2019-nCoV Case Investigation Team. First Case of 2019 Novel Coronavirus in the United States. N Engl J Med. 2020 Mar 5;382(10):929-936. doi: 10.1056/NEJMoa2001191. Epub 2020 Jan 31.
• Ksiazek TG, Erdman D, Goldsmith CS, Zaki SR, Peret T, Emery S, Tong S, Urbani C, Comer JA, Lim W, Rollin PE, Dowell SF, Ling AE, Humphrey CD, Shieh WJ, Guarner J, Paddock CD, Rota P, Fields B, DeRisi J, Yang JY, Cox N, Hughes JM, LeDuc JW, Bellini WJ, Anderson LJ; SARS Working Group. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med. 2003 May 15;348(20):1953-66. doi: 10.1056/NEJMoa030781. Epub 2003 Apr 10.
• Spina S, Marrazzo F, Migliari M, Stucchi R, Sforza A, Fumagalli R. The response of Milan's Emergency Medical System to the COVID-19 outbreak in Italy. Lancet. 2020 Mar 14;395(10227):e49-e50. doi: 10.1016/S0140-6736(20)30493-1. Epub 2020 Feb 28. No abstract available.
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Study record dates

Study Major Dates

• Study Start (Actual): April 10, 2020
• Primary Completion (Anticipated): April 1, 2022
• Study Completion (Anticipated): April 1, 2022

Study Registration Dates

• First Submitted: April 17, 2020
• First Submitted That Met QC Criteria: April 28, 2020
• First Posted (Actual): April 29, 2020

Study Record Updates

• Last Update Posted (Actual): September 5, 2021
• Last Update Submitted That Met QC Criteria: September 3, 2021
• Last Verified: August 1, 2021

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Ischemia; Pathologic Processes; Necrosis; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Respiratory Tract Diseases; Respiration Disorders; Lung Diseases; Signs and Symptoms, Respiratory; Myocardial Infarction; Infarction; Shock; Hypoxia; Respiratory Distress Syndrome; Shock, Cardiogenic
• Other Study ID Numbers: METC 2020-1343

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No