- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04706065
SHMT1 Polymorphism in Parkinson's Disease,
May 30, 2021 updated by: Effat AETony, MD, Assiut University
Genetic Polymorphisms of Serine Hydroxylmethyl Transferase 1 (SHMT1) in Patients With Parkinson's Disease
Parkinson Disease (PD) is the most common movement disorder and represents the second most common degenerative disease of the central nervous system .
SHMT has been shown to be associated with various diseases.
Study Overview
Status
Recruiting
Intervention / Treatment
Detailed Description
This case -control observational prospective study will conducted on 40 patients with PD.
Study Type
Observational
Enrollment (Anticipated)
80
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Effat a Tony, MD
- Phone Number: +201097330309
- Email: effattony@aun.edu.eg
Study Contact Backup
- Name: abeer a tony, MD
- Phone Number: +201005389084
- Email: abeer.tony@aswu.edu.eg
Study Locations
-
-
-
Assuit, Egypt, 71515
- Recruiting
- Effat abdelhady tony
-
Contact:
- Effat a tony, MD
- Phone Number: 01097330309
- Email: effattony@aun.edu.eg
-
Contact:
- abeer a tony, MD
- Phone Number: +201005389084
- Email: abeer_tony70@yahoo.com
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
50 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
patient with parkinson diisease
Description
Inclusion Criteria:
- Patients age ≥ 50 years.
- Patients with PD diagnosed according to the United Kingdom Parkinson's Disease Society Brain Bank (UK PDS Brain Bank diagnostic criteria)
Exclusion Criteria:
Patients with parkinsonian plus syndrome
- Patients with secondary parkinsonism
- Patients with other chronic comorbidities (renal, hepatic, and endocrinal disturbances and chronic chest disease.)
- Past and /or present history of epilepsy.
- Patients with disturbed conscious level.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
GROUP 1
Group 1 (patients with PD) All participants will be subjected to thorough history taking, full clinical and neurological examination.
Diagnosis of PD by using Brain Bank Criteria for diagnosis of Parkinson Disease , assessment of the severity of PD by using PDRS and evaluation of cognitive functions using MMSE.
|
It is to identify the role of SHMT1polymorphism in PD and examine the relationship between it and Severity of PD.
|
Group 2
Group 2 (controls) All participants will be subjected to thorough history taking, full clinical and neurological examination.
|
It is to identify the role of SHMT1polymorphism in PD and examine the relationship between it and Severity of PD.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
polymorphism of SHMT1gene
Time Frame: one year
|
one year
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
the role of SHMT1plymorphism in pathogenesis PD
Time Frame: one year
|
one year
|
Study the relationship of Shmt1 polymorphism to the severity of Parkinson disease
Time Frame: One year
|
One year
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Abeer a tony, MD, Assistant Professor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 31, 2021
Primary Completion (Anticipated)
July 1, 2021
Study Completion (Anticipated)
January 1, 2022
Study Registration Dates
First Submitted
January 3, 2021
First Submitted That Met QC Criteria
January 9, 2021
First Posted (Actual)
January 12, 2021
Study Record Updates
Last Update Posted (Actual)
June 2, 2021
Last Update Submitted That Met QC Criteria
May 30, 2021
Last Verified
May 1, 2021
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- aswan
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
UNDECIDED
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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