Resistance Training in Adults With Obesity

Acute and Chronic Effects of Two Different Types of Resistance Training on Cardiometabolic Health in Adults With Obesity

The purpose of this project is two-fold: (1) to assess if two different resistance training protocols elicit different responses in the acute phase and (2) to assess if the same two different protocols will elicit different long-term responses on muscular strength, body composition and cardiometabolic health. The project will include 30 adults with obesity (defined as BMI ≥ 30 or abdominal obesity according to the International Diabetes Federation). In the acute phase blood lactate, heart rate, enjoyment and perceived exertion will be assessed after the two resistance training protocols. In addition, the mean 24-h blood glucose concentration after exercise will be compared between the two protocols.

For the long-term effects blood markers of cardiometabolic health, blood pressure, body composition, objectively measured physical activity and physical fitness will be assessed before and after the intervention. Also, perceived health-related quality of life will be assessed before and after the intervention.

Study Overview

• Status: Completed
• Conditions: Overweight and Obesity
• Intervention / Treatment: Other: Moderate-repetition resistance training; Other: High-repetition resistance training

• Study Type: Interventional
• Enrollment (Actual): 31
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Norway
  • Trondheim, Norway, 7491
    • Department of Circulation and Medical Imaging

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Obesity (BMI ≥ 30) or
• Central obesity (defined according to the International Diabetes Federation).

Exclusion Criteria:

• Unstable angina
• recent cardiac infarction (last 4 weeks)
• uncompensated heart failure
• severe valvular illness
• pulmonary disease
• uncontrolled hypertension
• kidney failure
• orthopaedic/neurological limitations
• cardiomyopathy
• planned operations during the research period
• participation in a parallel study

Study Plan

How is the study designed?

Design Details

• Primary Purpose: PREVENTION
• Allocation: RANDOMIZED
• Interventional Model: PARALLEL
• Masking: NONE

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: Moderate-repetition resistance training; The participants will undergo a full-body resistance training protocol with moderate repetitions (6-12), moderate load (70-85% of 1RM), and moderate rest between sets (60-90s). Training will be undertaken three times per week.	Other: Moderate-repetition resistance training; Will undertake resistance training with moderate loads, and moderate repetitions 3 times per week for 7 weeks.
EXPERIMENTAL: High-repetition resistance training; The participants will undergo a full-body resistance training protocol with high repetitions (15+), low load (<60% of 1RM), and short rest between sets (30s). Training will be undertaken three times per week.	Other: High-repetition resistance training; Will undertake resistance training with low loads, and high repetitions 3 times per week for 7 weeks.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Glycated haemoglobin (HbA1c)	7 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Fasting glucose		7 weeks
Blood lipid concentration		7 weeks
C-reactive protein		7 weeks
Systolic blood pressure		7 weeks
Diastolic blood pressure		7 weeks
Body fat	Measured by bioelectrical impedance (InBody 770)	7 weeks
Fat-free mass	Measured by bioelectrical impedance (InBody 770)	7 weeks
Body mass	Measured by bioelectrical impedance (InBody 770)	7 weeks
Visceral fat area	Measured by bioelectrical impedance (InBody 770)	7 weeks
Waist circumference		7 weeks
VO2max (maximal aerobic capacity)		7 weeks
Rate of force development	Measured by Kistler force plate	7 weeks
Muscular strength (1RM)	Leg press and bench press	7 weeks
Muscular endurance	Maximum number of repetitions using 50% of 1-RM	7 weeks
Physical activity	Assessed at three timepoints throughout the intervention using SenseWear armband activity monitors and/or Personal Activity IntelligenceTM (using heart rate monitors and smart phone application).	Baseline (before intervention), 4 and 7 weeks.
Health-Related Quality of Life	Using the Short-Form 36 survey and Satisfaction with Physical Function and Appearance Survey	7 weeks

Collaborators and Investigators

• Sponsor: Norwegian University of Science and Technology

Study record dates

Study Major Dates

• Study Start (ACTUAL): October 14, 2021
• Primary Completion (ACTUAL): February 28, 2022
• Study Completion (ACTUAL): February 28, 2022

Study Registration Dates

• First Submitted: September 20, 2021
• First Submitted That Met QC Criteria: October 11, 2021
• First Posted (ACTUAL): October 25, 2021

Study Record Updates

• Last Update Posted (ACTUAL): May 26, 2022
• Last Update Submitted That Met QC Criteria: May 25, 2022
• Last Verified: May 1, 2022

More Information

Terms related to this study

• Keywords: Exercise therapy; Resistance training; Healthy lifestyle; Muscular strength; Fitness testing
• Additional Relevant MeSH Terms: Overnutrition; Nutrition Disorders; Body Weight; Obesity; Overweight
• Other Study ID Numbers: 246888

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No