Imbalances of Regional Pulmonary Ventilation in Patients With Post-acute-COVID-19

Imbalances of Regional Pulmonary Ventilation in Patients With Post-acute-COVID-19 Symptoms

Investigation of the correlation of CT-morphological changes of the lung compared to regional ventilation distribution on electrical impedance tomography in patients with post-acute-Covid-19 symptoms.

Study Overview

• Status: Not yet recruiting
• Conditions: Electric Impedance; COVID-19 Pneumonia; Post-acute COVID-19 Syndrome
• Intervention / Treatment: Diagnostic test: additional EIT Measurement

Detailed Description

Prospective non-interventional, monocentric observational study on imbalances in regional lung ventilation compared to chest CT in post-acute-Covid-19. The aim is to verify the agreement between computerized tomography derived imaging variables and electrical impedance tomography in detecting lung ventilation imbalances. The primary study objective is to match CT morphological changes in regional ventilation in post-acute-COVID-19 patients and/or changes in lung function examination, with changes that can be visualized by electroimpedance tomography.

• Study Type: Observational
• Enrollment (Estimated): 50

Contacts and Locations

• Study Contact: Name: Jan-Christoph Lewejohann, Dr.; Phone Number: +49 3641 9 32 20 13; Email: jan-christoph.lewejohann@med.uni-jena.de
• Study Contact Backup: Name: Phillip A. Reuken, Dr.; Phone Number: +49 3641 9 32 4504; Email: Philipp.reuken@med.uni-jena.de

Study Locations

• Germany
  • Thuringia
    • Jena, Thuringia, Germany, 07747
      • Klinik für Notfallmedizin

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

All patients presenting to the post-COVID-19 outpatient clinic are screened.

Description

Inclusion Criteria:

• all patients undergoing a Chest CT due to suspected post-acute-Covid-19-syndrome
• >18 years
• informed consent.

Exclusion Criteria:

• trauma patients and patients with unstable spinal injuries or fractures
• patients with an BMI over 50
• patients with uncontrolled body movements
• Patients with a pacemaker

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Control cohort; lung-healthy volunteers get a EIT measurement
Case cohort; Patients who receive standard CT and pulmonary function testing also receive electroimpedance tomography measurement	Diagnostic test: additional EIT Measurement; Patients who receive standard CT and pulmonary function testing also receive electroimpedance tomography measurement. The lunghealthy Patients in the control group only receive a EIT.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Correlation between tomography and electroimpedance tomography	The primary study objective is to match CT morphological changes in regional ventilation in post-COVID patients and/or changes in lung function examination with changes that can be visualized by electroimpedance tomography.	until May 2022

Secondary Outcome Measures

Outcome Measure	Time Frame
Correlation between lung function testing and electroimpedance tomography	until May 2022

Collaborators and Investigators

• Sponsor: Jan-Christoph Lewejohann
• Investigators: Study Director: Phillip A Reuken, Dr., Jena University Hospital, Klinik für Innere Medizin IV

Study record dates

Study Major Dates

• Study Start (Estimated): October 1, 2025
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): March 31, 2027

Study Registration Dates

• First Submitted: February 8, 2022
• First Submitted That Met QC Criteria: February 11, 2022
• First Posted (Actual): February 14, 2022

Study Record Updates

• Last Update Posted (Estimated): September 25, 2025
• Last Update Submitted That Met QC Criteria: September 22, 2025
• Last Verified: September 1, 2025

More Information

Terms related to this study

• Keywords: CT; Tomography; long-COVID; EIT; Electric Impedance; electroimpedance tomography; post-COVID-19; regional ventilation; post-acute-COVID-19 syndrome
• Additional Relevant MeSH Terms: Post-Infectious Disorders; COVID-19; Pathologic Processes; Chronic Disease; Disease Attributes; Respiratory Tract Infections; Infections; RNA Virus Infections; Virus Diseases; Respiratory Tract Diseases; Lung Diseases; Pneumonia, Viral; Pneumonia; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; Pathological Conditions, Signs and Symptoms; Post-Acute COVID-19 Syndrome
• Other Study ID Numbers: KIM-IV-EIT03

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No