Aerobic Capacity and Physical Fitness Level of Adolescents With PCOS

Comparison of Aerobic Capacity and Physical Fitness Level of Adolescents With Polycystic Ovary Syndrome and Healthy Peers

Polycystic Ovary Syndrome (PCOS) is associated with hyperandrogenism, hyperinsulinemia and insulin resistance starting in the perimenarchal period. Insulin resistance also increases the risk of developing glucose intolerance, type 2 diabetes, hypertension, dyslipidemia and cardiovascular disorders. Studies on adult women with PCOS show that their aerobic capacity is affected. Therefore, in this study; it was aimed to compare the physical and cardiovascular fitness levels of adolescent PCOS patients with healthy adolescents.

Study Overview

• Status: Completed
• Conditions: Polycystic Ovary Syndrome

Detailed Description

Polycystic Ovary Syndrome (PCOS) is associated with hyperandrogenism, hyperinsulinemia and insulin resistance starting in the perimenarchal period. Insulin resistance also increases the risk of developing glucose intolerance, type 2 diabetes, hypertension, dyslipidemia and cardiovascular disorders. Studies on adult women with PCOS show that their aerobic capacity is affected. Therefore, in this study; it was aimed to compare the physical and cardiovascular fitness levels of adolescent PCOS patients with healthy adolescents.Total fat and muscle ratios will be measured with the bioelectrical impedance test (BIA) instrument for body composition evaluation of individuals in both groups. Body mass index (BMI), waist/hip and waist/height ratios will be recorded. The level of cardiovascular fitness will be evaluated with the PACER test, which is among the Fitness Gram Test Protocol. For physical fitness level, muscular strength parameter will be evaluated with hand dynamometer and knee extensor muscle strength, and muscular endurance parameter will be evaluated with sit-up and push-up tests. Participants' physical activities will be evaluated with the Adolescent Physical Activity Questionnaire (PAQ-A).The quality of life of individuals with PCOS will be evaluated with the Polycystic Ovary Syndrome Quality of Life-50 Scale.

• Study Type: Observational
• Enrollment (Actual): 44

Contacts and Locations

Study Locations

• Turkey
  • Ankara, Turkey, 06100
    • Hacettepe University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 14 years to 24 years (Child, Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

• Sampling Method: Probability Sample

Study Population

Healthy group: Being in the adolescent group, not having any chronic disease and being willing to participate in the study.

Patient group: Being in the adolescent group, being diagnosed with polycystic ovary syndrome and being willing to participate in the study

Description

Inclusion Criteria of patients :

• Being between the ages of 14-24,
• Collecting Polycystic Syndrome according to Rotherdam,
• Not having had Covid-19.

Exclusion Criteria of the patients :

• Not to be between the ages of 14-24,
• Not showing the symptoms of Polycystic Ovary Syndrome (PCOS),
• Having had Covid-19,
• Having a chronic disease diagnosed other than PCOS,
• Having cognitive impairment that will affect their cooperation with tests.

Healthy group inclusion criteria

• Being a female adolescent between the ages of 14-24,
• Not having been diagnosed with any chronic disease,
• Adolescents with regular menstrual cycles,
• Not taking any medication known to affect hormone, lipid and carbohydrate metabolism,
• Not having clinical signs of hyperandrogenism,
• Not having had Covid-19.

Healthy group exclusion criteria

• Not to be between the ages of 14-24,
• Having a chronic disease,
• Having had Covid-19,
• Having cognitive impairment that will affect their cooperation with tests.

Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Control
• Time Perspectives: Cross-Sectional

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Healthy group; Healthy adolescents aged 14-24 who have not been diagnosed with any chronic disease
Patient with PCOS group; Adolescents between the ages of 14-24 diagnosed with Polycystic Ovary Syndrome according to the Rotherdam criteria.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Aerobic Exercise Capacity	PACER running test, which is included in the fitnessgram test protocol, will be used to evaluate aerobic capacity.	1 day
Physical Fitness	The Fitnessgram Test Protocol will be used for physical fitness assessment.	1 day

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Peripheral Muscle Strength	With the Lafayette Manual Muscle Test System Model01165, knee extensor muscle strength will be measured in individuals in sitting position and knee extension. 3 repetitions will be applied for the right and left sides and the results will be recorded in kilograms.	1 day
Physical Activity Level	Adolescent Physical Activity Questionnaire (PAQ-A) will be administered to both groups. This questionnaire is designed to assess physical activity in the last 7 days. It consists of 8 questions in which the answers given are scored between 1 and 5, and 9 questions questioning the existence of a situation that prevents physical activity in the last week.	1 day
Life quality	The quality of life of individuals with Polycystic Ovary Syndrome will be evaluated with the Polycystic Ovary Syndrome Quality of Life-50 Scale. This scale consists of six parameters including psychosocial and status, fertility, sexual function, obesity and menstrual irregularity, hair growth and coping with the disease, and includes 50 questions. When calculating the total score and sub-dimension scores of the scale, it is scored as 5 never, rarely 4, sometimes 3, often 4, always 1.	1 day
Body composition analysis	Body fat percentage (%), body muscle percentage (%), body water percentage (%), body fat weight (kg), body muscle weight (kg) will be recorded according to Bioelectrical Impedance Analysis.	1 day

Collaborators and Investigators

• Sponsor: Hacettepe University
• Collaborators: Dr. Sami Ulus Children's Hospital
• Investigators: Principal Investigator: Ebru Calik Kutukcu, PhD, Hacettepe University

Study record dates

Study Major Dates

• Study Start (Actual): September 22, 2021
• Primary Completion (Actual): September 21, 2022
• Study Completion (Actual): September 21, 2022

Study Registration Dates

• First Submitted: January 21, 2022
• First Submitted That Met QC Criteria: February 17, 2022
• First Posted (Actual): February 18, 2022

Study Record Updates

• Last Update Posted (Actual): October 12, 2022
• Last Update Submitted That Met QC Criteria: October 9, 2022
• Last Verified: October 1, 2022

More Information

Terms related to this study

• Keywords: aerobic capacity; physical fitness
• Additional Relevant MeSH Terms: Pathologic Processes; Neoplasms; Endocrine System Diseases; Disease; Ovarian Cysts; Cysts; Ovarian Diseases; Adnexal Diseases; Gonadal Disorders; Polycystic Ovary Syndrome; Syndrome
• Other Study ID Numbers: GO 21/947

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No