A Study to Evaluate Long-term Safety of Nintedanib in Children and Adolescents With Interstitial Lung Disease (InPedILD®-ON)

An Open-label Trial of the Long-term Safety and Tolerability of Nintedanib Per os, on Top of Standard of Care, Over at Least 3 Years, in Children and Adolescents With Clinically Significant Fibrosing Interstitial Lung Disease (InPedILD®-ON)

This study is open to children and adolescents with interstitial lung disease (ILD) that causes lung fibrosis. This is a study for people who took part in a previous study (study 1199-0337, InPedILD™) and for people who are between 6 and 17 years old and have fibrosing ILD.

This study tests a medicine called nintedanib. Nintedanib is already used to treat different types of lung fibrosis in adults. The purpose of the study is to find out how well long-term treatment with nintedanib is tolerated in children and adolescents.

All participants take nintedanib capsules twice a day. Participants are in the study for at least 1 year and 5 months or until nintedanib or other treatment options become available outside of this study. During the first 3 years, they visit the study site about 15 times. Afterwards, they visit the study site every 3 months.

The doctors collect information on any health problems of the participants.

Study Overview

• Status: Active, not recruiting
• Conditions: Lung Diseases, Interstitial
• Intervention / Treatment: Drug: Nintedanib (Ofev®)

• Study Type: Interventional
• Enrollment (Actual): 54
• Phase: Phase 3

Contacts and Locations

• Study Contact: Name: Boehringer Ingelheim; Phone Number: 1-800-243-0127; Email: clintriage.rdg@boehringer-ingelheim.com

Study Locations

• Argentina
  • Caba, Argentina, C1245AAM
    • Hospital de Pediatría " Prof. Dr. Juan P. Garrahan"
  • Caba, Argentina, C1425EFD
    • Hospital de Niños Dr. Ricardo Gutiérrez
• Belgium
  • Bruxelles, Belgium, 1020
    • Brussels - UNIV HUDERF
• Brazil
  • Barra Mansa, Brazil, 27323240
    • Serviços Medicos Respirar Sul Fluminense
• Canada
  • British Columbia
    • Vancouver, British Columbia, Canada, V6H 3N1
      • BC Children's Hospital
  • Ontario
    • Toronto, Ontario, Canada, M5G 1X8
      • The Hospital for Sick Children
• Czechia
  • Praha 5, Czechia, 150 06
    • Teaching Hospital Motol, Oncology Clinic
• Finland
  • Tampere, Finland, 33520
    • Tampere University Hospital
• France
  • Créteil, France, 94010
    • HOP Intercommunal
• Germany
  • Hamburg, Germany, 22081
    • Hamburger Zentrum für Kinder- und Jugendrheumatologie
• Greece
  • Thessaloniki, Greece, 54642
    • General Hospital of Thessaloniki "Ippokrateio"
• Italy
  • Firenze, Italy, 50139
    • Azienda Ospedaliera Meyer
  • Roma, Italy, 00165
    • Osp. Pediatrico Bambin Gesù
• Mexico
  • Tlalnepantla, Mexico, 54055
    • Clinical Research Institute S.C.
• Norway
  • Oslo, Norway, N-0372
    • Oslo universitetssykehus HF, Rikshospitalet
• Poland
  • Warsaw, Poland, 02091
    • Independent Public Teaching Children's Hospital
• Portugal
  • Lisboa, Portugal, 1169-045
    • ULS de São José, E.P.E. - Hospital Dona Estefânia
  • Lisboa, Portugal, 1649-035
    • ULS de Santa Maria, E.P.E
• Spain
  • Barcelona, Spain, 08035
    • Hospital Vall d'Hebron
  • Sevilla, Spain, 41013
    • Hospital Virgen del Rocío
• United Kingdom
  • London, United Kingdom, SE5 9RS
    • King's College Hospital
• United States
  • California
    • Los Angeles, California, United States, 90027
      • Children's Hospital Los Angeles
  • Colorado
    • Aurora, Colorado, United States, 80045
      • Children's Hospital Colorado
  • New York
    • New York, New York, United States, 10021
      • Weill Cornell Medicine
  • Pennsylvania
    • Philadelphia, Pennsylvania, United States, 19104
      • Children's Hospital of Philadelphia
    • Pittsburgh, Pennsylvania, United States, 15224
      • Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center
  • Tennessee
    • Nashville, Tennessee, United States, 37232
      • Vanderbilt University Medical Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 6 years to 17 years (Child)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

For new patients:

1. Children and adolescents 6 to 17 years old at Visit 2.
2. Signed and dated written informed consent and assent, where applicable, in accordance with ICH-GCP and local legislation prior to admission to the trial.
3. Male or female patients. Female of childbearing potential (WOCBP1) must confirm that sexual abstinence is standard practice and will be continued until 3 months after last drug intake, or be ready and able to use a highly effective method of birth control per ICH M3 (R2) that results in a low failure rate of less than 1% per year when used consistently and correctly, in combination with one barrier method, from 28 days prior to initiation of study treatment, during treatment and until 3 months after last drug intake. Sexual abstinence is defined as abstinence from any sexual act that may result in pregnancy.
4. Patients with evidence of fibrosing Interstitial Lung Disease (ILD) on High-Resolution Computed Tomography (HRCT) within 12 months of Visit 1 as assessed by the investigator and confirmed by central review.
5. Patients with Forced Vital Capacity (FVC) % predicted ≥25% at Visit 2.

6. Patients with clinically significant disease at Visit 2, as assessed by the investigator based on any of the following:

   • Fan score ≥3, or

   • Documented evidence of clinical progression over time based on either

     • a 5-10% relative decline in FVC % predicted accompanied by worsening symptoms, or
     • a ≥10% relative decline in FVC % predicted, or
     • increased fibrosis on HRCT, or
     • other measures of clinical worsening attributed to progressive lung disease (e.g. increased oxygen requirement, decreased diffusion capacity).

   For roll-over patients from the InPedILD® study:

   Only criteria 2 and 3 listed for new patients are applicable with the following additional inclusion criterion:

7. Patients who completed the InPedILD® trial as planned and who did not permanently prematurely discontinue study treatment.

For patients who prematurely discontinued treatment permanently in 1199-0337 but are potentially eligible and for completed patients from parent trial not able to roll over into the extension trial within 12 weeks following their End of Treatment Visit in the parent trial:

Inclusion criteria for new patients are applicable except criteria 4, and 6 (as eligibility for these criteria has been confirmed already in 1199-0337 and does not need to be repeated) and also except inclusion criterion 1 for completed patients from parent trial not able to roll over within 12 weeks following their End of Treatment Visit in the parent trial.

Exclusion Criteria:

For new patients:

1. Aspartate Aminotransferase (AST) and/or Alanine Aminotransferase (ALT) >1.5 x Upper limit of normal (ULN) at Visit 1.
2. Bilirubin >1.5 x ULN at Visit 1.
3. Estimated Glomerular Filtration Rate (eGFR) <30 mL/min/1.73 m² at Visit 1
4. Patients with underlying chronic liver disease (Child Pugh A, B or C hepatic impairment) at Visit 1.
5. Other investigational therapy received within 1 month or 5 half-lives (whichever is shorter but ≥1 week) prior to Visit 2 except investigational therapy received in InPedILD® trial.

6. Significant pulmonary arterial hypertension (PAH) defined by any of the following:

   • Previous clinical or echocardiographic evidence of significant right heart failure
   • History of right heart catheterization showing a cardiac index ≤2 l/min/m²
   • PAH requiring parenteral therapy with epoprostenol/treprostinil
7. In the opinion of the Investigator, other clinically significant pulmonary abnormalities.

8. Cardiovascular diseases, any of the following:

   • Severe hypertension, uncontrolled under treatment, within 6 months of Visit 1. Uncontrolled hypertension is defined as

     • In children 6 to ≤12 years old: ≥95th percentile + 12 mm Hg or ≥140/90 mm Hg (whichever is lower) (systolic or diastolic blood pressure equal to or greater than the calculated target value)
     • In adolescents 13 to 17 years old: systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg
   • Myocardial infarction within 6 months of Visit 1
   • Unstable cardiac angina within 6 months of Visit 1

9. Bleeding risk, any of the following:

   • Known genetic predisposition to bleeding

   • Patients who require

     • Fibrinolysis, full-dose therapeutic anticoagulation (e.g. vitamin K antagonists, direct thrombin inhibitors, heparin, hirudin)
     • High dose antiplatelet therapy
   • History of haemorrhagic central nervous system (CNS) event within 12 months of Visit 1

   • Any of the following within 3 months of Visit 1:

     • Haemoptysis or haematuria
     • Active gastro-intestinal (GI) bleeding or GI - ulcers
     • Major injury or surgery (investigator's judgment)

   • Any of the following coagulation parameters at Visit 1:

     • International normalized ratio (INR) >2
     • Prolongation of prothrombin time (PT) by >1.5 x ULN
     • Prolongation of activated partial thromboplastin time (aPTT) by >1.5 x ULN
10. History of thrombotic event (including stroke and transient ischemic attack) within 12 months of Visit 1.
11. Known hypersensitivity to the trial medication or its components (i.e. soya lecithin).
12. Patients with documented allergy to peanut or soya.
13. Other disease that may interfere with testing procedures or in the judgment of the investigator may interfere with trial participation or may put the patient at risk when participating in this trial.
14. Life expectancy for any concomitant disease other than ILD <2.5 years (investigator assessment).
15. Female patients who are pregnant, nursing, or who plan to become pregnant while in the trial.
16. Patients not able or willing to adhere to trial procedures, including intake of study medication.
17. Patients who must or wish to take any drug considered likely to interfere with the safe conduct of the trial according to investigator's benefit-risk assessment for the individual patient
18. Patients with any diagnosed growth disorder such as growth hormone deficiency or any genetic disorder that is associated with short stature (e.g. Turner Syndrome, Noonan Syndrome, Russell-Silver Syndrome) and/or treatment with growth hormone therapy within 6 months before Visit 2. Patients with short stature considered by the investigator to be due to glucocorticoid therapy may be included.

19. Patients <13.5 kg of weight at Visit 1 (same threshold to be used for male and female patients).

    For roll-over patients from the InPedILD® study:

    Only criteria 11, 12, 13, 15, 16, 17 and 19, listed for new patients are applicable with the following additional exclusion criterion:

20. Patient not compliant in parent trial (InPedILD®), with trial medication or trial visits, according to investigator's judgement. Roll-over patients may qualify for participation even though other exclusion criteria may have been met during the participation in InPedILD®, if the investigator's benefit-risk assessment for the individual patient remains favorable.

    For patients who prematurely discontinued treatment permanently in 1199-0337 but are potentially eligible and for completed patients from parent trial not able to roll over into the extension trial within 12 weeks following their End of Treatment Visit in the parent trial:

    All exclusion criteria for new patients are applicable. In addition, the following additional exclusion criterion is applicable for patients who prematurely discontinued treatment permanently in 1199-0337:

21. Patients who experienced drug-related adverse events during parent trial leading to permanent study treatment discontinuation.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Patients rolling over from the InPedILD® study	Drug: Nintedanib (Ofev®); Nintedanib (Ofev®) soft capsules
Experimental: Patients newly enrolled in this study	Drug: Nintedanib (Ofev®); Nintedanib (Ofev®) soft capsules

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Incidence of treatment emergent adverse events	up to 41 months

Collaborators and Investigators

• Sponsor: Boehringer Ingelheim

Publications and helpful links

Helpful Links

• Related Info

Study record dates

Study Major Dates

• Study Start (Actual): April 4, 2022
• Primary Completion (Estimated): July 14, 2025
• Study Completion (Estimated): August 11, 2025

Study Registration Dates

• First Submitted: March 10, 2022
• First Submitted That Met QC Criteria: March 10, 2022
• First Posted (Actual): March 18, 2022

Study Record Updates

• Last Update Posted (Actual): April 16, 2024
• Last Update Submitted That Met QC Criteria: April 15, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Lung Diseases; Lung Diseases, Interstitial; Molecular Mechanisms of Pharmacological Action; Enzyme Inhibitors; Antineoplastic Agents; Protein Kinase Inhibitors; Nintedanib
• Other Study ID Numbers: 1199-0378; 2020-005554-23 (EudraCT Number)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES

IPD Plan Description

Once the criteria in section "Time Frame" are fulfilled, researchers can use the following link https://www.mystudywindow.com/msw/datasharing to request access to the clinical study documents regarding this study, and upon a signed "Document Sharing Agreement".

Furthermore, researchers can request access to the clinical study data, for this and other listed studies, after the submission of a research proposal and according to the terms outlined in the website.

• IPD Sharing Time Frame: After structured results have been posted, all regulatory activities are completed in the US and EU for the product and indication, and after the primary manuscript has been accepted for publication.
• IPD Sharing Access Criteria: For study documents - upon signing of a 'Document Sharing Agreement'. For study data - 1. after the submission and approval of the research proposal (checks will be performed by the sponsor and/or the independent review panel, including checking that the planned analysis does not compete with sponsor's publication plan); 2. and upon signing of a legal agreement.
• IPD Sharing Supporting Information Type: STUDY_PROTOCOL; SAP; CSR

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: Yes
• Studies a U.S. FDA-regulated device product: No