- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05502003
The Effect of Telerehabilitation on Symptoms in Fibromyalgia Patients
March 25, 2023 updated by: Selin Akıl Ağdere, Saglik Bilimleri Universitesi
Effect Of High Intensity Interval Upper Extremity Training On Biochemistry Parameters And Disease Symptoms In Patients With Fibromyalgia
The aim of this study is to evaluate the effect of telerehabilitation-based high-intensity interval upper extremity exercise training on biochemistry parameters and disease symptoms in fibromyalgia patients.
It has been reported that substances such as serotonin and tryptophan are found at abnormal levels in the serotonergic system in patients with fibromyalgia, and symptoms such as depression, pain, and fatigue related to the disease may be associated with this condition.
In the literature, there are studies conducted in other disease groups showing that aerobic exercise regulates tryptophan and serotonin levels and can produce positive results regarding these symptoms.
This study was planned to evaluate the effect of high-intensity interval exercise training, which is an aerobic exercise form, whose benefits are frequently mentioned in recent publications, on both blood parameters and symptoms in fibromyalgia patients.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
Fibromyalgia is a chronic musculoskeletal disease of unknown etiology accompanied by symptoms such as pain, hyperalgesia, sleep disorders, fatigue and mood disorders.
It has been suggested that a defect in the serotonergic system is involved in the pathophysiology of the disease.
The serotonergic system has been associated with many symptoms such as anxiety, depression, sleep problems, fatigue and pain.
In studies on fibromyalgia, it was reported that plasma tryptophan and serotonin levels decreased in this patient group and that serotonin levels were abnormal in the endogenous pain blocking pathways.
Although conflicting results have been reported, it was stated that vitamin D levels were also low in this patient group.
Aerobic exercise makes muscles use branched-chain amino acids, reducing the amount of amino acids that compete with tryptophan and increasing the chance of tryptophan to cross the blood-brain barrier.
Therefore, it has the potential to increase serotonin in the brain.
In particular, aerobic exercise appears to modulate hormone, neurotrophin and neurotransmitter levels, depending on factors such as genes, age and hormonal status.
On the other hand, it is reported that some types of exercise increase the production of free radicals and cause oxidative stress.
It has been suggested that oxidative stress may be associated with pain, which is one of the main symptoms in fibromyalgia patients by affecting nociceptors.
Studies have shown that when aerobic exercises are applied regularly for a long time, lipid peroxidation level, which is an indicator of oxidative stress, decreases and antioxidant enzyme activity increases.
Regularly applied aerobic exercise programs have been reported as a suitable form of exercise for this patient group.
Recent studies have focused on high-intensity interval training.
This type of exercise; It is performed as successive short and intermittent sessions of high-intensity activity with periods of low intensity or rest.
High-intensity interval training are shorter than moderate aerobic workouts and produce the same or more positive effects than moderate exercise.
It is also reported that high-intensity interval training application improves oxidative capacity, antioxidant defense and endothelial functions.
Telerehabilitation practices refer to the use of telematics procedures using telephone, video and computer technologies instead of traditional face-to-face approaches.
The therapist ensures that patient communication and follow-up are maintained by maintaining social distance.
It has been stated in studies that telerehabilitation can be used to increase the quality of life, to provide socialization and to treat pain in patients with fibromyalgia.
This study was designed to evaluate the effectiveness of high-intensity interval training upper extremity exercise training, which is a form of aerobic exercise, on these parameters, associated symptoms and oxidative stress markers in fibromyalgia patients with negative effects on serotonin, tryptophan, vitamin D and related parameters.
Study Type
Interventional
Enrollment (Actual)
33
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Bakırköy
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Istanbul, Bakırköy, Turkey
- University of Health Sciences Bakırkoy Dr. Sadi Konuk Training and Research Hospital
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 65 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Participants diagnosed with fibromyalgia according to the American College of Rheumatology 2016 criteria.
- Participants between the ages of 18-65
- Participants who do not use a drug that will affect the treatment results
- Participants who volunteer
Exclusion Criteria:
- Infection
- Fever
- Any known advanced-stage pathology associated with the locomotor system that contraindicates physical activity.
- Cardiopulmonary problem
- Presence of autoimmune disease
- Pregnancy
- Malignancy
- Severe psychiatric problem
- Neurological disorder
- Epilepsy
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: High Intensity Interval Training
With the arm ergometer given to the participants, a telerehabilitation-based upper extremity aerobic exercise program will be applied.
Maximum Heart Rate (MHR) will be determined by the formula '220-age', and exercise intensity will be calculated, and exercise will begin with a 5 minute warm-up.
Cycle will be created with 4 min MHR (80-95%) high intensity and 3 min MHR (70%) active recovery and exercise will be terminated with 5 min cool down.
A total of 35 minutes of exercise program will be given.
|
Telerehabilitation-based high-intensity exercise training will be applied to the participants for 6 weeks, 3 times a week for 35 minutes, under the control of a physiotherapist.
|
Active Comparator: Moderate Exercise Training
An upper extremity exercise program with telerehabilitation (Zoom/videoconference) will be applied to the moderate-intensity exercise group.
Maximum heart rate (MHR) will be determined by the formula 220-Age.
A total of 55 minutes of moderate exercise training will be given at 65-70% of MHR, with five minutes of warm-up and cool-down.
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The participants will be given telerehabilitation-based moderate exercise training under the control of a physiotherapist for 55 minutes, 3 times a week for 6 weeks.
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No Intervention: Control
No aerobic exercise program will be applied to this group.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Assessment of serum free tryptophan
Time Frame: 6 weeks
|
Blood will be drawn from the participants in the morning.
Centrifugation will be performed and the blood taken will be frozen.The analysis will be completed by following the manufacturer's instructions of the appropriate kits.
|
6 weeks
|
Assessment of 5-Hydroxyindolacetic Acid
Time Frame: 6 weeks
|
Blood will be drawn from the participants in the morning.
Centrifugation will be performed and the blood taken will be frozen.The analysis will be completed by following the manufacturer's instructions of the appropriate kits.
|
6 weeks
|
Assessment of Superoxide dismutase
Time Frame: 6 weeks
|
Superoxide dismutase is the most important enzymatic antioxidants that prevent the initiation of lipid peroxidation.
Blood will be drawn from the participants in the morning.
Centrifugation will be performed and the blood taken will be frozen.
The analysis will be completed by following the manufacturer's instructions of the appropriate kits.
|
6 weeks
|
Assessment of Glutathione Peroxidase
Time Frame: 6 weeks
|
Glutathione Peroxidase is the most important enzymatic antioxidants that prevent the initiation of lipid peroxidation.
Blood will be drawn from the participants in the morning.
Centrifugation will be performed and the blood taken will be frozen.
The analysis will be completed by following the manufacturer's instructions of the appropriate kits.
|
6 weeks
|
Assessment of Malondialdehyde
Time Frame: 6 weeks
|
Blood will be drawn from the participants in the morning.
Centrifugation will be performed and the blood taken will be frozen.
The analysis will be completed by following the manufacturer's instructions of the appropriate kits.
|
6 weeks
|
Assessment of Myeloperoxidase
Time Frame: 6 weeks
|
Blood will be drawn from the participants in the morning.
Centrifugation will be performed and the blood taken will be frozen.
The analysis will be completed by following the manufacturer's instructions of the appropriate kits.
|
6 weeks
|
Assessment of 25-hydroxy vitamin D
Time Frame: 6 weeks
|
Blood will be drawn from the participants in the morning.
Centrifugation will be performed and the blood taken will be frozen.
The analysis will be completed by following the manufacturer's instructions of the appropriate kits.
|
6 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Pressure Pain Threshold Assessment
Time Frame: 6 weeks
|
Pressure pain threshold assessment will be done with an algometer.
|
6 weeks
|
Evaluation of Grip Strength
Time Frame: 6 weeks
|
Grip strength will be evaluated with a dynamometer (Hydraulic hand dynamometer).
|
6 weeks
|
Evaluation of Fatigue
Time Frame: 6 weeks
|
Fatigue will be evaluated with Fatigue Severity Scale.
Each item of the scale, which consists of 9 items that patients can apply on their own, is scored between 1 and 7 (1 = strongly disagree, 7 = completely agree) and the total score is calculated by taking the average of 9 items.
The lower the total score, the less fatigue.
|
6 weeks
|
Evaluation of Depression and Anxiety
Time Frame: 6 weeks
|
Depression and anxiety will be evaluated with Hospital Anxiety and Depression Scale.
Each item of the 14-item scale is scored between 0 and 3.
For anxiety and depression values, 0-7 points are considered normal, 8-10 points are borderline, and 11 points and above are considered abnormal.
|
6 weeks
|
Evaluation of Quality of Sleep
Time Frame: 6 weeks
|
Quality of Sleep will be evaluated with Pittsburgh Sleep Quality Index.
The total score is between 0-21.
A high total score indicates poor sleep quality.
|
6 weeks
|
Evaluation of Functional Status Assessment
Time Frame: 6 weeks
|
Functional Status Assessment will be evaluated with The Revised Fibromyalgia Impact Questionnaire.
A high score indicates that the disease affects the person more.
|
6 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Schwarz MJ, Offenbaecher M, Neumeister A, Ackenheil M. Experimental evaluation of an altered tryptophan metabolism in fibromyalgia. Adv Exp Med Biol. 2003;527:265-75. doi: 10.1007/978-1-4615-0135-0_30.
- Siracusa R, Paola RD, Cuzzocrea S, Impellizzeri D. Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update. Int J Mol Sci. 2021 Apr 9;22(8):3891. doi: 10.3390/ijms22083891.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
August 25, 2022
Primary Completion (Actual)
January 25, 2023
Study Completion (Actual)
January 25, 2023
Study Registration Dates
First Submitted
August 10, 2022
First Submitted That Met QC Criteria
August 12, 2022
First Posted (Actual)
August 16, 2022
Study Record Updates
Last Update Posted (Actual)
March 28, 2023
Last Update Submitted That Met QC Criteria
March 25, 2023
Last Verified
March 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- aerobic exercise
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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