A Phase I Intravesical PPM Therapy for NMIBC

A Phase I Trial of Cancer-targeting Micelles for Non-myoinvasive Bladder Cancer

This clinical trial is to determine the safety and effectiveness of an investigational bladder cancer drug named "PLZ4-coated paclitaxel-loaded nanoscale micelle (PPM)." PPM is tiny particles that contain the chemotherapy drug paclitaxel. PLZ4 is a molecule that can possibly guide PPM to specifically target and deliver paclitaxel into and kill bladder cancer cells. In this trial, PPM will be instilled into the bladder cavity to treat bladder cancer that does not invade into the muscle layer of the bladder and that has failed the treatment of another drug BCG. Up to 29 patients will be enrolled into the trial. The main goal of this trial is to determine the dose of PPM for future clinical trials, assess the toxicity and obtain preliminary data regarding its effectiveness.

Study Overview

• Status: Recruiting
• Conditions: Non-muscle-invasive Bladder Cancer
• Intervention / Treatment: Drug: PLZ4-coated paclitaxel-loaded micelles (PPM)

Detailed Description

The goal of this project is to conduct a Phase I clinical trial to determine the recommended Phase II dose (RP2D) of bladder cancer-targeting micelles loaded with a chemotherapeutic drug paclitaxel (PTX). The investigators previously developed a bladder cancer-specific targeting ligand named PLZ4, and a PLZ4-coated PTX-loaded nanoscale micelle (PPM) platform that can specifically deliver the drug load into bladder cancer cells both in vitro and in vivo. This proposed clinical trial is to conduct a first-in-human trial to use PPM for the treatment of non-myoinvasive bladder cancer (NMIBC). This primary objective of the proposed Phase I trial is to determine the recommended Phase II dose (RP2D) of PPM. The secondary objectives are to assess the toxicity, obtain preliminary efficacy information of PPM, and determine systemic absorption after intravesical instillation of PPM. Up to 29 patients with recurrent or refractory NMIBC after a standard first-line intravesical BCG treatment will be recruited. PPM will be given as intravesical instillation once weekly for six weeks. The toxicity will be assessed by the NCI Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. The efficacy will be determined by urine cytology and cystoscopy after finishing treatment. Molecular correlative studies will be performed.

• Study Type: Interventional
• Enrollment (Estimated): 29
• Phase: Phase 1

Contacts and Locations

• Study Contact: Name: Chong-Xian Pan, MD PhD; Phone Number: (857) 203-6189; Email: chong-xian.pan@va.gov
• Study Contact Backup: Name: Juan Garisto Risco, MD; Phone Number: (617) 323-7700; Email: juan.garistorisco@va.gov

Study Locations

• United States
  • Massachusetts
    • Boston, Massachusetts, United States, 02130-4817
      • Recruiting
      • VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
      • Contact: Chong-Xian Pan, MD PhD; Phone Number: 857-203-6189; Email: chong-xian.pan@va.gov
      • Principal Investigator: Chong-Xian Pan, MD PhD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

Patients must meet all of the following criteria to be eligible for study entry.

• Histologically confirmed bladder carcinoma in situ (CIS) urothelial or urothelial carcinoma, with or without T1 cancer. Patients are eligible if the biopsy was done within 3 months of enrollment and a cystoscopy demonstrates no gross disease invasion into muscularis propria within 4 weeks of enrollment.

• Patient must have BCG-unresponsive non-muscle-invasive bladder cancer (NMIBC) or intolerance of treatment with BCG. Treatment of pembrolizumab is not an inclusion or exclusion criteria as intravesical taxane probably has comparable efficacy as intravenous pembrolizumab. BCG-unresponsive disease is defined as being at least one of the following:

  • Persistent or recurrent CIS alone or with recurrent Ta/T1 (noninvasive papillary disease/tumor invades the subepithelial connective tissue) disease within 12 months of completion of adequate BCG therapy
  • Recurrent high-grade Ta/T1 disease within 6 months of completion of adequate BCG therapy
  • T1 high-grade disease at the first evaluation following an induction BCG course

In this context, adequate BCG therapy is defined as at least one of the following:

• At least five of six doses of an initial induction course plus at least two of three doses of maintenance therapy

• At least five of six doses of an initial induction course plus at least two of six doses of a second induction course

  • Refuse or intolerant of a radical cystectomy recommended by the treating urologist as the standard next therapy per urologic guidelines.
  • Age 18 years.
  • Performance status: ECOG performance status of 0, 1, or 2 (Appendix A) or Karnofsky performance status of 50 or higher (Appendix B).
  • Patient with life expectancy greater than 24 months.
  • No concurrent radiotherapy, chemotherapy, or other immunotherapy
  • No scheduled radiotherapy, chemotherapy, other immunotherapy, or surgery before the scheduled response evaluation.
  • Recovery from prior treatment side effects that might interfere with the study treatment, in the judgment of the participating urologist.
  • Laboratory tests performed within 14 days of study enrollment:
• Absolute neutrophil count (AGC/ANC) 1,500/uL
• Platelets 100,000/uL [Patients may be transfused to meet this requirement]
• Hemoglobin 8 g/dL [Patients may be transfused to meet this requirement]
• Calculated glomerular filtration rate (GFR) 50 mL/min/1.73m2
• Total bilirubin 2.0 X ULN (< 3 x ULN for patients with Gilbert's syndrome)

• AST, ALT, ALP 3.0 X ULN

  • Adequate pulmonary function with no clinical signs of severe pulmonary dysfunction.
  • Negative serum pregnancy test if the study participant is a female and of childbearing potential (non-childbearing is defined as greater than one year postmenopausal or surgically sterilized).
  • Female participants of childbearing potential must adhere to using a medically accepted method of birth control, i.e. a tubal ligation, an approved hormonal contraceptive or an intrauterine device, prior to screening and agree to continue its use during the study and up to 3 months after finishing this study or be surgically sterilized (e.g., hysterectomy or tubal ligation). Males must agree to use barrier methods of birth control while on study.
  • Provide signed informed consent and HIPAA authorization and agree to comply with all protocol-specified procedures and follow-up evaluations.

Exclusion Criteria:

Patients who meet any of the following criteria will be excluded from study entry.

• Existence of cancer at the upper urinary tract
• Concurrent use of other investigational agents.
• Evidence of regional and/or distant metastasis.
• NYHA (New York Heart Association) Class III or IV heart failure (Appendix C), uncontrollable supraventricular arrhythmias, any history of a ventricular arrhythmia, or other clinical signs of severe cardiac dysfunction.
• Symptomatic congestive heart failure (CHF), severe/unstable angina pectoris, or myocardial infarction within 6 months prior to study entry.
• Patient has an intractable bleeding disorder (e.g., coagulation factors deficiencies, Von Willebrand Disease).
• Patient taking medications that affect coagulation, such as aspirin (aspirin 81 mg oral once daily is allowed), Coumadin/Warfarin, heparin, low molecular weight heparin, direct thrombin inhibitors, and direct factor Xa inhibitors. Other nonsteroidal anti-inflammatory drugs (NSAIDs) are allowed as long as they are discontinued the day before therapy.
• History or evidence of uncontrollable central nervous system (CNS) disease.
• Active systemic infection requiring parenteral antibiotic therapy.
• Women who are pregnant or nursing.
• Psychiatric illness/social situations that would limit compliance with study requirements
• Other illness that in the opinion of the investigator would exclude the patient from participating in this study.

• Any other malignancy diagnosed within 3 years of trial entry with the exception of:

  • Basal or squamous cell skin cancers, or
  • Noninvasive cancer of the cervix, or
  • Any other cancer deemed to be of low-risk for progression or patient morbidity during trial period, such as localized prostate cancer after definitive treatment and prostate-specific antigen (PSA) less than 0.2 ng/ml.
• Patients unwilling to or unable to comply with the protocol.
• Patients with impaired decision-making capacity.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Phase I dose-escalation and expansion cohort; There are three doses at the dose escalation stage: Dose level I: paclitaxel (PTX) 25 mg or 0.5 mg/ml; Dose Level II: PTX 50 mg or 1.0 mg/ml; Dose Level III: PTX 75 mg or 1.5 mg/ml. At the expansion cohort, up to 12 patients will be recruited and treated with PPM at the PTX dose of 50 mg or 1.0 mg/ml to determine the efficacy.	Drug: PLZ4-coated paclitaxel-loaded micelles (PPM); PPM will be administrated weekly for 6 times through intravesical instillation into the bladder cavity

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
adverse events	CTCAE v5.0 will be used to determine any adverse events and assess the grade. All toxicity as well as Grade 3 or higher adverse events will be analyzed.	up to 3 months after the last dose

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
complete response rate	urine cytology, cystoscopy.	6 weeks after finishing the last dose of PPM

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
blood paclitaxel concentration	Blood will be drawn up to a few hours after the first dose of PPM at the expansion cohort to determine the systemic paclitaxel absorption.	within 6 hours after administration

Collaborators and Investigators

• Sponsor: VA Office of Research and Development
• Collaborators: University of California, Davis
• Investigators: Principal Investigator: Chong-Xian Pan, MD PhD, VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA

Study record dates

Study Major Dates

• Study Start (Actual): October 10, 2022
• Primary Completion (Estimated): August 31, 2026
• Study Completion (Estimated): August 31, 2026

Study Registration Dates

• First Submitted: August 18, 2022
• First Submitted That Met QC Criteria: August 24, 2022
• First Posted (Actual): August 29, 2022

Study Record Updates

• Last Update Posted (Actual): October 4, 2023
• Last Update Submitted That Met QC Criteria: October 2, 2023
• Last Verified: October 1, 2023

More Information

Terms related to this study

• Keywords: paclitaxel; intravesical instillation; non-muscle-invasive bladder cancer; BCG-refractory
• Additional Relevant MeSH Terms: Neoplasms by Histologic Type; Neoplasms; Urologic Neoplasms; Urogenital Neoplasms; Neoplasms by Site; Urologic Diseases; Carcinoma; Neoplasms, Glandular and Epithelial; Urinary Bladder Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Urinary Bladder Neoplasms; Non-Muscle Invasive Bladder Neoplasms; Molecular Mechanisms of Pharmacological Action; Antineoplastic Agents; Tubulin Modulators; Antimitotic Agents; Mitosis Modulators; Antineoplastic Agents, Phytogenic; Paclitaxel
• Other Study ID Numbers: ONCA-021-20S; VA Merit (Other Grant/Funding Number: 1I01CX002247)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: The published data is readily available after publications. Unpublished data will be available upon request. No individual participant data will be shared.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: Yes
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No