- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05814718
Modified BEAM Regimen for T Cell Lymphoma Underwent ASCT
Multicenter Randomized Controlled Clinical Study of Mitoxantrone Hydrochloride Liposome Injection Combined With Carmustine, Etoposide and Cytarabine (Modified BEAM Protocol) for T Cell Lymphoma Underwent Autologous Stem Cell Transplantation
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Xiaoning Wang, M.D.
- Phone Number: +8618991232608
- Email: wangxn99@163.com
Study Contact Backup
- Name: xiaonig wang, M.D.
- Phone Number: +8618991232608
- Email: wangxn99@163.com
Study Locations
-
-
Shaanxi
-
Xi'an, Shaanxi, China, 710061
- First Affiliated Hospital of Xian Jiaotong University
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
1) Subjects volunteered to participate in the study, signed the informed consent form, had good compliance and cooperated with follow-up 2) 18~60 years old (including upper and lower limits) 3) Patients who were pathologically diagnosed as T-cell lymphoma and planned to undergo autologous hematopoietic stem cell transplantation 4) ECOG score 0-1 5) Organ function level must meet the following requirements:
- Liver: aspartate aminotransferase (AST), alanine aminotransferase (ALT) ≤ 3 times the upper limit of normal (ULN), total bilirubin (TBIL) ≤ 1.5 × ULN (AST, ALT ≤ 5 is allowed in case of liver invasion × ULN);
- Kidney: blood creatinine ≤ 1.5 × ULN;
- Coagulation function: International normalized ratio (INR) and activated partial thromboplastin time (APTT) ≤ 1.5 × ULN;
- Normal cardiac function: normal or abnormal ECG, no clinical significance, left ventricular ejection fraction (LVEF) shown by cardiac ultrasound is greater than 60, or myocardial zymogram CK-MB is normal, and pro BNP is less than 900 pg/ml 6) The serum pregnancy test results of female subjects with reproductive capacity must be negative before the first use of the test drug
Exclusion Criteria:
1.The previous anti-tumor treatment history of the subject meets one of the following conditions:
- Those who have previously received mitoxantrone or mitoxantrone liposomes
- Have received doxorubicin or other anthracyclines before, and the total cumulative dose of doxorubicin is more than 360 mg/m2 (1 mg doxorubicin equivalent to 2 mg epirubicin for other anthracyclines) 2. Hypersensitivity to any study drug or its components 3. Uncontrollable systemic diseases (such as active infection, uncontrollable hypertension, diabetes, etc.) 4. Heart function and disease meet one of the following conditions:
- Long QTc syndrome or QTc interval>480 ms
- Complete left bundle branch block, grade II or III atrioventricular block
- Serious and uncontrolled arrhythmia requiring drug treatment
- American New York Heart Association rating ≥ III
- Cardiac ejection fraction (LVEF) is less than 60%
A history of myocardial infarction, unstable angina, severe unstable ventricular arrhythmia or any other arrhythmia requiring treatment, a history of clinically serious pericardial disease, or ECG evidence of acute ischemia or active conduction system abnormality within 6 months before recruitment.
5. Active infection of hepatitis B and hepatitis C (hepatitis B virus surface antigen is positive and hepatitis B virus DNA exceeds 1x103 copies/mL, hepatitis C virus RNA exceeds 1x103 copies/mL) 6. Human immunodeficiency virus (HIV) infection (HIV antibody positive) 7. Have had or are suffering from other malignant tumors at the same time (except for effectively controlled non melanoma skin basal cell carcinoma, breast/cervical carcinoma in situ, and other malignant tumors that have not been treated and have been effectively controlled in the past five years) 8. Have primary or secondary CNS lymphoma or have a history of CNS lymphoma at the time of recruitment 9. Pregnant and lactating women and childbearing age patients unwilling to take contraceptive measures 10. Those who have a history of drug abuse (use of narcotic drugs or psychotropic drugs for non-medical purposes) or dependence on drugs (sedative hypnotics, analgesics, narcotics, stimulants, and psychotropic drugs, etc.) 11. History of mental illness or cognitive impairment 12. Other investigators judged that it was not suitable to participate in this study.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: modified BEAM conditioning regimen
Mitoxantrone liposome 24 mg/m2,ivgtt,d-7;BCNU 300 mg/m2,ivgtt,d-6; Ara-C 200 mg/m2 q12h,ivgtt,d-5- -2; Vp16 200 mg/m2 ,ivgtt,d-5- -2;
|
Mitoxantrone liposome 24 mg/m2,ivgtt,d-7;BCNU 300 mg/m2,ivgtt,d-6; Ara-C 200 mg/m2 q12h,ivgtt,d-5- -2; Vp16 200 mg/m2 ,ivgtt,d-5- -2;
Other Names:
|
Active Comparator: BEAM conditioning regimen
BCNU 300 mg/m2,-7d; Vp16 200 mg/m2,-6~-3d; Ara-C 100mg/m2 q12h,-6~-3d; Mel 140mg/m2,-2d
|
BCNU 300 mg/m2,-7d; Vp16 200 mg/m2,-6~-3d; Ara-C 100mg/m2 q12h,-6~-3d; Mel 140mg/m2,-2d
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
relapse rate of T cell lymphoma
Time Frame: three years after transplantation
|
relapse rate at three years after transplantation
|
three years after transplantation
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
OS
Time Frame: From date of diagnosis until the end of follow-up or the date of death from any cause, whichever came first,assessed up to 36 months.
|
overall survival
|
From date of diagnosis until the end of follow-up or the date of death from any cause, whichever came first,assessed up to 36 months.
|
PFS
Time Frame: From date of HSCT until the end of follow-up or the date of disease relapse from any cause, whichever came first,assessed up to 36 months.
|
progression free survival
|
From date of HSCT until the end of follow-up or the date of disease relapse from any cause, whichever came first,assessed up to 36 months.
|
AEs
Time Frame: from beginning of the conditioning to one month after conditioning
|
adverse reactions included gastrointestinal,liver,renal,heart toxicities
|
from beginning of the conditioning to one month after conditioning
|
immune reconstruction
Time Frame: At 6 months post-transplantation
|
the recovery of T, B and NK cells
|
At 6 months post-transplantation
|
Collaborators and Investigators
Investigators
- Principal Investigator: Xiaoning Wang, First Affiliated Hospital Xi'an Jiaotong University
Study record dates
Study Major Dates
Study Start (Anticipated)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Immune System Diseases
- Neoplasms by Histologic Type
- Neoplasms
- Lymphoproliferative Disorders
- Lymphatic Diseases
- Immunoproliferative Disorders
- Lymphoma, Non-Hodgkin
- Lymphoma
- Lymphoma, T-Cell
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Anti-Infective Agents
- Peripheral Nervous System Agents
- Antiviral Agents
- Enzyme Inhibitors
- Analgesics
- Sensory System Agents
- Antimetabolites, Antineoplastic
- Antimetabolites
- Antineoplastic Agents
- Immunosuppressive Agents
- Immunologic Factors
- Antineoplastic Agents, Alkylating
- Alkylating Agents
- Myeloablative Agonists
- Antineoplastic Agents, Phytogenic
- Topoisomerase II Inhibitors
- Topoisomerase Inhibitors
- Etoposide
- Etoposide phosphate
- Melphalan
- Cytarabine
- Mitoxantrone
- Carmustine
Other Study ID Numbers
- XJTU1AF2022LSL-018
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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