- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05822895
Review of the Impact of a Computer-aided Real-time Polyp Detection System on Adult Colonoscopy (COPILOT)
A Comprehensive Review of the Impact of a COmPuter-aIded reaL-time pOlyp deTection System on Adult Colonoscopy (COPILOT Study) - a Single Institution Adoption Experience
Background:
Removal of adenomatous polyps during colonoscopy is associated with long-term prevention of colorectal cancer-related deaths. Recently, there have been much interest in the use of artificial intelligence (AI) platforms to augment the routine endoscopic assessment of the colon to enhance adenoma detection rate (ADR). To date, computer assisted detection of polyps (CADe) have been shown to be safe, with a significant increase in ADR, without any concomitant increase in post-procedural complications.
Aims:
The investigators aim to evaluate the use of GI GeniusTM Intelligent Endoscopy Module in a multi-ethnic Asian population (Singapore) to increase in ADR and adenoma detected per colonoscopy (ADPC)to justify its effectiveness as an adjunct in polyp detection and training for colonoscopy.
Methods:
This study will be a single-institution cohort study, conducted over a 2-year period. Sengkang General Hospital (SKH) does an estimated 12,500 colonoscopies per year, with an average of 1,040 colonoscopies performed every month. Thus, given the case volume, the investigators expect to detect differences in ADR amongst endoscopists if any during this study period.
As part of the subgroup analysis, the investigators also aim to compare the ADR rates of trainee endoscopists with and without the GI GeniusTM Intelligent Endoscopy Module to ascertain its utility as an education tool/training adjunct
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
This study will be a single-institution cohort study, conducted over a 2-year period. The investigators will recruit patients prospectively who would have their colonoscopy performed with AI guidance from the GI Genius, which is a standard of care feature in the endoscopy rooms fitted with the GI Genius, and compare it against historical data when the AI technology was not available (Jan 2018-Jan 2021). This historical data has already been collected as part of a published audit performed for SKH's endoscopy. The data collected for this historical cohort are from an anonymised database collected from Operating Theatre Management Unit (OTMU) (who is not involved in the study).
For the prospective cohort undergoing AI aided endoscopy (1/4/2023 - 31/3/2025):
This will include all adult patients going for colonoscopy in the our institution. Patients with incomplete or failed colonoscopy, flexible sigmoidoscopy, colonoscopy done after previous colorectal cancers or previous colonic resections, patients with poor bowel preparation, when deemed by the endoscopist to have an incomplete assessment of the colon, will be excluded from the analysis.
patient demographical data, procedural related data as well as histology from histological reports from their colonoscopy would be collected by research coordinators in order to ascertain ADR, Adenoma Detection Per Colonoscopy (ADPC) and Polyp Detection Rate (PDR).
These coordinators are independent of the study team and will not be part of the analysis of the data. In order to have an effective barrier (for the study team not to be able to identify the patients from the data collected), therefore the coordinators act as a trusted independent party who will extract/de-identify the data before it is handed to the study team for analysis of the ADR ADPC and PDR. The study team will not attempt to re- identify the patients back.
Analysis of data:
Subsequent analysis will be conducted at every 3 months by reviewing for the absolute ADR and ADPC amongst endoscopists by the study team. By comparing these prospectively collected data with the historical cohort data, the investigators would be able to evaluate the effectiveness of the GI Genius in improving the ADR, PDR and ADPC. Cost analysis can also be done to analyse the cost effectiveness of the added AI feature.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Frederick H Koh, FRCSEd
- Phone Number: +65-84281117
- Email: frederick.koh.h.x@singhealth.com.sg
Study Locations
-
-
-
Singapore, Singapore, 544886
- Recruiting
- Sengkang General Hospital
-
Contact:
- Frederick H Koh, FRCSEd
- Phone Number: 65 84281117
- Email: frederick.koh.h.x@singhealth.com.sg
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- all adult patients going for colonoscopy in the our institution
Exclusion Criteria:
- Patients with incomplete or failed colonoscopy, flexible sigmoidoscopy, colonoscopy done after previous colorectal cancers or previous colonic resections, patients with poor bowel preparation, when deemed by the endoscopist to have an incomplete assessment of the colon
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Computer-aided polyp detection
patients undergoing colonoscopy with CADe enabled programme
|
CADe enabled programme (GI Genius)
|
without CADe
patients undergoing colonoscopy without CADe enabled programme
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
ADR
Time Frame: 2 weeks for Histological results to return
|
Adenoma detection rate
|
2 weeks for Histological results to return
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
ADPC
Time Frame: 2 weeks, for histological results to return
|
Adenoma detection per colonscopy rate
|
2 weeks, for histological results to return
|
Collaborators and Investigators
Sponsor
Collaborators
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2022/2695
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Colonic Polyp
-
University of ManitobaActive, not recruitingPolyps | Colonic Polyp | Polyp of Colon | Colo-rectal Cancer | Colon Polyp | Rectal Polyp | Polyp RectalCanada
-
South Tyneside and Sunderland NHS Foundation TrustMedtronic; Newcastle University; North Wales Organisation for Randomised Trials...CompletedColonic Polyp | Colorectal Adenoma | Colorectal Polyp | Colorectal SSA | Colorectal Adenomatous Polyp | Sessile Serrated Adenoma | Sessile Colonic PolypUnited Kingdom
-
Vejle HospitalNot yet recruitingColorectal Cancer | Colonic Polyp | Colorectal Polyp | Shared Decision Making | Decision Aids | Rectal Polyp
-
Wulumuqi General Hospital of Lanzhou Military CommandAir Force Military Medical University, ChinaCompletedColonic Polyp | Intestinal PolypChina
-
Olympus Europe SE & Co. KGRecruitingColonic PolypSpain, Germany, Sweden
-
The University of Texas Health Science Center,...Recruiting
-
Unity Health TorontoRecruiting
-
Wuerzburg University HospitalCompleted
-
Valduce HospitalCompleted
-
Parc de Salut MarUnknown
Clinical Trials on CADe enabled programme (GI Genius)
-
King's College Hospital NHS TrustMedtronic; National Institute for Health Research, United KingdomRecruitingColonic Polyp | Colo-rectal Cancer | Colonic AdenomaUnited Kingdom
-
Cosmo Artificial Intelligence-AI LtdCompletedArtificial IntelligenceItaly
-
Fondazione Poliambulanza Istituto OspedalieroRecruitingAdenoma | Polyp of Colon | Colonic AdenomaItaly
-
Centre hospitalier de l'Université de Montréal...University of British Columbia; McGill University; Université de Sherbrooke; University...RecruitingArtificial IntelligenceCanada
-
Fondazione Poliambulanza Istituto OspedalieroRecruitingRectal Neoplasms | Colonic Neoplasms | Rectal Adenocarcinoma | Colonic Adenocarcinoma | Polyps of ColonItaly
-
Hospital Universitario La FeMedtronic; European Society of Gastrointestinal EndoscopyRecruiting
-
Nuovo Regina Margherita HospitalCompleted
-
Marshall UniversityEnrolling by invitationColon Cancer Screening | Colon Cancer SurveillanceUnited States
-
Asociación Española de GastroenterologíaMedtronicCompletedGastrointestinal Neoplasms | Colorectal Neoplasms | Intestinal Neoplasms | Colorectal Cancer | Colonic Polyp | Adenoma Colon | Serrated Polyp | Serrated AdenomaSpain
-
Haraldsplass Deaconess HospitalHaukeland University Hospital; Kanalspesialistene AS; European Society of Gastrointestinal...Recruiting