- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05874713
Study to Evaluate Safety and Immunogenicity of Different Priming and Booster Regimens With Adjuvanted H5N8 and/or H5N6 Influenza Vaccine in Adults
A Phase 2, Multi-Center, Randomized, Observer-Blind Study, to Evaluate Safety and Immunogenicity of Homologous or Heterologous Priming and Booster Vaccinations With H5N8 or H5N6 MF59-adjuvanted, Cell Culture-derived Influenza Vaccine in Healthy Subjects ≥18 Years of Age
This Phase 2, randomized, observer-blind clinical study is evaluating 3 different priming and booster regimens with MF59-adjuvanted H5N8 and/or H5N6 cell culture-derived influenza vaccine (aH5N8c; aH5N6c). Approximately 480 healthy adult subjects are to be randomized into 1 of 3 possible treatment groups, stratified by age group (18-64 years and ≥65 years) and by poultry worker status (yes/no). Each subject will receive a priming influenza vaccine injection on Day 1 and Day 22 and a booster vaccination on Day 202. Subjects will be followed up for approximately 6 months after the booster injection.
The primary immunogenicity analysis is based on antibody responses against H5N8 and H5N6 as measured by hemagglutination inhibition (HI) assay on Day 1, Day 22, Day 29, Day 43, Day 202, Day 209 (H5N8 only), and Day 223.
Study Overview
Status
Study Type
Enrollment (Actual)
Phase
- Phase 2
Contacts and Locations
Study Contact
- Name: Clinical Trial Disclosure Manager
- Phone Number: use email
- Email: seqirus.clinicaltrials@seqirus.com
Study Contact Backup
- Name: Therapeutic Area Head
Study Locations
-
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Alabama
-
Cullman, Alabama, United States, 35055
- Cullman Clinical Trials
-
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Georgia
-
Lilburn, Georgia, United States, 30047
- Lifeline Primary Care
-
Norcross, Georgia, United States, 30092
- Georgia Clinic
-
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Iowa
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Sioux City, Iowa, United States, 51106
- Velocity Clinical Research
-
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Louisiana
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Baton Rouge, Louisiana, United States, 70809
- Meridian Clinical Research
-
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Nebraska
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Grand Island, Nebraska, United States, 68803
- Meridian Clinical Research
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Norfolk, Nebraska, United States, 68701
- Meridian Clinical Research
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Tennessee
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Elizabethton, Tennessee, United States, 37643
- Medical Care LLC
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Utah
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Salt Lake City, Utah, United States, 84010
- Cope Family Medicine
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Individuals of ≥18 years of age on the day of informed consent.
- Individuals who or whose legally acceptable representative(s) have voluntarily given written consent after the nature of the study has been explained according to local regulatory requirements, prior to study entry.
- Individuals who can comply with study procedures including follow-up.
- Males, females of non-childbearing potential or females of childbearing potential who are using an effective birth control method which they intend to use for at least 30 days before the first study vaccination and plan to do so until 2 months after the last study vaccination.
- Individuals must provide a baseline blood sample prior to randomization and vaccination.
Exclusion Criteria:
- Females of childbearing potential who are pregnant, lactating, or who have not adhered to a specified set of contraceptive methods from at least 30 days prior to study entry and who do not plan to do so until 2 months after the last study vaccination.
- Progressive, unstable or uncontrolled clinical conditions.
- Hypersensitivity, including allergy, to any component of vaccines, medicinal products or medical equipment whose use is foreseen in this study.
- Clinical conditions representing a contraindication to intramuscular vaccination and blood draws.
Abnormal function of the immune system resulting from:
- Clinical conditions.
- Systemic administration of corticosteroids at a dose ≥20 mg/day of prednisone (or equivalent) for more than 14 consecutive days within 90 days prior to informed consent. Topical, inhaled and intranasal corticosteroids are permitted. Intermittent use (one dose in 30 days) of intra-articular corticosteroids are also permitted.
- Administration of antineoplastic and immunomodulating agents or radiotherapy within 90 days prior to informed consent.
- History of any medical condition considered an AESI.
- Received immunoglobulins with immunomodulating effects or any blood products within 180 days prior to informed consent.
- Individuals who previously received an H5 influenza vaccine or have a known history of H5 influenza infection prior to enrollment.
- Received an investigational or non-registered medicinal product within 30 days prior to informed consent or are unwilling to refuse participation in another clinical study at any time during the conduct of this study.
- Study personnel or immediate family or household member of study personnel.
- Any other clinical condition that, in the opinion of the investigator, might interfere with the results of the study or pose additional risk to the individual due to participation in the study.
- Individuals who received any other vaccines (with the exception of COVID-19 vaccines) within 14 days (for inactivated vaccines) or 28 days (for live vaccines) prior to enrolment in this study or who are planning to receive any vaccine within 28 days from any of the 3 scheduled study vaccinations.
- Receipt of any (investigational or licensed) COVID-19 vaccine within 14 days (non-replicating vaccines) or 28 days (replicating vaccines) prior to enrollment or plan to receive any COVID-19 vaccine within 7 days from any of the 3 scheduled study vaccinations.
- A known history of Guillain-Barre Syndrome or other demyelinating diseases such as encephalomyelitis and transverse myelitis.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Triple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Arm A
Eligible subjects who have been randomized to receive aH5N8c on Day 1, Day 22 and Day 202
|
MF59-adjuvanted cell-culture derived subunit inactivated monovalent A/H5N8 vaccine (aH5N8c) for intramuscular administration, containing intermediate dose H5N8 hemagglutinin + standard dose MF59 (approximately 0.5 mL total volume)
MF59-adjuvanted cell-culture derived subunit inactivated monovalent A/H5N8 vaccine (aH5N8c) for intramuscular administration, containing intermediate dose H5N8 hemagglutinin + standard dose MF59 (approximately 0.5 mL total volume)
MF59-adjuvanted cell-culture derived subunit inactivated monovalent A/H5N8 vaccine (aH5N8c) for intramuscular administration, containing intermediate dose H5N8 hemagglutinin + standard dose MF59 (approximately 0.5 mL total volume)
|
Experimental: Arm B
Eligible subjects who have been randomized to receive aH5N8c on Day 1, aH5N6c on Day 22, and aH5N8c on Day 202
|
MF59-adjuvanted cell-culture derived subunit inactivated monovalent A/H5N8 vaccine (aH5N8c) for intramuscular administration, containing intermediate dose H5N8 hemagglutinin + standard dose MF59 (approximately 0.5 mL total volume)
MF59-adjuvanted cell-culture derived subunit inactivated monovalent A/H5N8 vaccine (aH5N8c) for intramuscular administration, containing intermediate dose H5N8 hemagglutinin + standard dose MF59 (approximately 0.5 mL total volume)
MF59-adjuvanted cell-culture derived subunit inactivated monovalent A/H5N6 vaccine (aH5N6c) for intramuscular administration, containing intermediate dose H5N6 hemagglutinin + standard dose MF59 (approximately 0.5 mL total volume)
|
Experimental: Arm C
Eligible subjects who have been randomized to receive aH5N6c on Day 1 and aH5N8c on Day 22 and Day 202
|
MF59-adjuvanted cell-culture derived subunit inactivated monovalent A/H5N8 vaccine (aH5N8c) for intramuscular administration, containing intermediate dose H5N8 hemagglutinin + standard dose MF59 (approximately 0.5 mL total volume)
MF59-adjuvanted cell-culture derived subunit inactivated monovalent A/H5N8 vaccine (aH5N8c) for intramuscular administration, containing intermediate dose H5N8 hemagglutinin + standard dose MF59 (approximately 0.5 mL total volume)
MF59-adjuvanted cell-culture derived subunit inactivated monovalent A/H5N6 vaccine (aH5N6c) for intramuscular administration, containing intermediate dose H5N6 hemagglutinin + standard dose MF59 (approximately 0.5 mL total volume)
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Geometric mean titer (GMT) of hemagglutination inhibition (HI) antibodies against H5N8 strain - Day 1
Time Frame: Day 1
|
GMT (HI) prevaccination
|
Day 1
|
GMT of HI antibodies against H5N8 strain - Day 22
Time Frame: Day 22
|
GMT (HI) 3 weeks post first priming vaccination
|
Day 22
|
GMT of HI antibodies against H5N8 strain - Day 43
Time Frame: Day 43
|
GMT (HI) 3 weeks post second priming vaccination
|
Day 43
|
GMT of HI antibodies against H5N8 strain - Day 202
Time Frame: Day 202
|
GMT (HI) pre booster vaccination
|
Day 202
|
GMT of HI antibodies against H5N8 strain - Day 209
Time Frame: Day 209
|
GMT (HI) 1 week post booster vaccination
|
Day 209
|
GMT of HI antibodies against H5N8 strain - Day 223
Time Frame: Day 223
|
GMT (HI) 3 weeks post booster vaccination
|
Day 223
|
GMT of HI antibodies against H5N6 strain - Day 1
Time Frame: Day 1
|
GMT (HI) prevaccination
|
Day 1
|
GMT of HI antibodies against H5N6 strain - Day 22
Time Frame: Day 22
|
GMT (HI) 3 weeks post first priming vaccination
|
Day 22
|
GMT of HI antibodies against H5N6 strain - Day 43
Time Frame: Day 43
|
GMT (HI) 3 weeks post second priming vaccination
|
Day 43
|
GMT of HI antibodies against H5N6 strain - Day 202
Time Frame: Day 202
|
GMT (HI) pre booster vaccination
|
Day 202
|
GMT of HI antibodies against H5N6 strain - Day 223
Time Frame: Day 223
|
GMT (HI) 3 weeks post booster vaccination
|
Day 223
|
Geometric mean fold increase (GMFI) of HI antibodies against H5N8 strain - Day 22
Time Frame: Day 22
|
GMFI (HI) 3 weeks post first priming vaccination compared to prevaccination
|
Day 22
|
GMFI of HI antibodies against H5N8 strain - Day 43
Time Frame: Day 43
|
GMFI (HI) 3 weeks post second priming vaccination compared to prevaccination
|
Day 43
|
GMFI of HI antibodies against H5N8 strain - Day 209
Time Frame: Day 209
|
GMFI (HI) 1 week post booster vaccination compared to pre booster vaccination
|
Day 209
|
GMFI of HI antibodies against H5N8 strain - Day 223
Time Frame: Day 223
|
GMFI (HI) 3 weeks post booster vaccination compared to pre booster vaccination
|
Day 223
|
GMFI of HI antibodies against H5N6 strain - Day 22
Time Frame: Day 22
|
GMFI (HI) 3 weeks post first priming vaccination compared to prevaccination
|
Day 22
|
GMFI of HI antibodies against H5N6 strain - Day 43
Time Frame: Day 43
|
GMFI (HI) 3 weeks post second priming vaccination compared to prevaccination
|
Day 43
|
GMFI of HI antibodies against H5N6 strain - Day 223
Time Frame: Day 223
|
GMFI (HI) 3 weeks post booster vaccination compared to pre booster vaccination
|
Day 223
|
Percentages of subjects with HI titers ≥1:40 against H5N8 strain - Day 1
Time Frame: Day 1
|
% ≥1:40 (HI) prevaccination
|
Day 1
|
Percentages of subjects with HI titers ≥1:40 against H5N8 strain - Day 22
Time Frame: Day 22
|
% ≥1:40 (HI) 3 weeks post first priming vaccination
|
Day 22
|
Percentages of subjects with HI titers ≥1:40 against H5N8 strain - Day 43
Time Frame: Day 43
|
% ≥1:40 (HI) 3 weeks post second priming vaccination
|
Day 43
|
Percentages of subjects with HI titers ≥1:40 against H5N8 strain - Day 209
Time Frame: Day 209
|
% ≥1:40 (HI) 1 week post booster vaccination
|
Day 209
|
Percentages of subjects with HI titers ≥1:40 against H5N8 strain - Day 223
Time Frame: Day 223
|
% ≥1:40 (HI) 3 weeks post booster vaccination
|
Day 223
|
Percentages of subjects with HI titers ≥1:40 against H5N6 strain - Day 1
Time Frame: Day 1
|
% ≥1:40 (HI) prevaccination
|
Day 1
|
Percentages of subjects with HI titers ≥1:40 against H5N6 strain - Day 22
Time Frame: Day 22
|
% ≥1:40 (HI) 3 weeks post first priming vaccination
|
Day 22
|
Percentages of subjects with HI titers ≥1:40 against H5N6 strain - Day 43
Time Frame: Day 43
|
% ≥1:40 (HI) 3 weeks post second priming vaccination
|
Day 43
|
Percentages of subjects with HI titers ≥1:40 against H5N6 strain - Day 223
Time Frame: Day 223
|
% ≥1:40 (HI) 3 weeks post booster vaccination
|
Day 223
|
Percentages of subjects with seroconversion by HI against H5N8 strain - Day 22
Time Frame: Day 22
|
% seroconversion (HI) 3 weeks post first priming vaccination, defined as a ≥4-fold increase in HI titer postvaccination in those with prevaccination titer ≥1:10, or a postvaccination HI titer ≥1:40 for subjects with prevaccination titer <1:10
|
Day 22
|
Percentages of subjects with seroconversion by HI against H5N8 strain - Day 43
Time Frame: Day 43
|
% seroconversion (HI) 3 weeks post second priming vaccination, defined as a ≥4-fold increase in HI titer postvaccination in those with pre-vaccination titer ≥1:10, or a postvaccination HI titer ≥1:40 for subjects with prevaccination titer <1:10
|
Day 43
|
Percentages of subjects with seroconversion by HI against H5N8 strain - Day 209
Time Frame: Day 209
|
% seroconversion (HI) 1 week post booster vaccination, defined as a ≥4-fold increase in HI titer postvaccination in those with pre-vaccination titer ≥1:10, or a postvaccination HI titer ≥1:40 for subjects with prevaccination titer <1:10
|
Day 209
|
Percentages of subjects with seroconversion by HI against H5N8 strain - Day 223
Time Frame: Day 223
|
% seroconversion (HI) 3 weeks post booster vaccination, defined as a ≥4-fold increase in HI titer postvaccination in those with pre-vaccination titer ≥1:10, or a postvaccination HI titer ≥1:40 for subjects with prevaccination titer <1:10
|
Day 223
|
Percentages of subjects with seroconversion by HI against H5N6 strain - Day 22
Time Frame: Day 22
|
% seroconversion (HI) 3 weeks post first priming vaccination, defined as a ≥4-fold increase in HI titer postvaccination in those with pre-vaccination titer ≥1:10, or a postvaccination HI titer ≥1:40 for subjects with prevaccination titer <1:10
|
Day 22
|
Percentages of subjects with seroconversion by HI against H5N6 strain - Day 43
Time Frame: Day 43
|
% seroconversion (HI) 3 weeks post second priming vaccination, defined as a ≥4-fold increase in HI titer postvaccination in those with pre-vaccination titer ≥1:10, or a postvaccination HI titer ≥1:40 for subjects with prevaccination titer <1:10
|
Day 43
|
Percentages of subjects with seroconversion by HI against H5N6 strain - Day 223
Time Frame: Day 223
|
% seroconversion (HI) 3 weeks post booster vaccination, defined as a ≥4-fold increase in HI titer postvaccination in those with pre-vaccination titer ≥1:10, or a postvaccination HI titer ≥1:40 for subjects with prevaccination titer <1:10
|
Day 223
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Frequency and severity of solicited local and systemic adverse events (AEs)
Time Frame: Day 1 through Day 7, Day 22 through Day 28, and Day 202 through 208
|
For 7 consecutive days following each vaccination (ie, Day 1 through Day 7, Day 22 through Day 28, and Day 202 through 208, or until symptom resolution if ongoing at Day 7, Day 28 or Day 208 for a maximum of 14 days postvaccination).
|
Day 1 through Day 7, Day 22 through Day 28, and Day 202 through 208
|
Frequency and severity of unsolicited AEs
Time Frame: Day 1 through Day 43 and Day 202 through Day 223
|
For 3 weeks following each vaccination
|
Day 1 through Day 43 and Day 202 through Day 223
|
Frequency and severity of serious AEs (SAEs), AEs leading to withdrawal, AEs of special interest (AESI), and medically attended AEs (MAAEs)
Time Frame: Day 1 through Day 382
|
From first vaccination until study completion
|
Day 1 through Day 382
|
GMT of HI antibodies against H5N8 strain - Persistence
Time Frame: Day 202, Day 382
|
GMT (HI) 6 months post 2nd priming vaccination and 6 months post booster vaccination
|
Day 202, Day 382
|
GMT of HI antibodies against H5N6 strain - Persistence
Time Frame: Day 202
|
GMT (HI) 6 months post 2nd priming vaccination
|
Day 202
|
GMFI of HI antibodies against H5N8 strain - Persistence
Time Frame: Day 202, Day 382
|
GMFI (HI) 6 months post 2nd priming vaccination compared to prevaccination (Day 1), and 6 months post booster vaccination compared to prevaccination (Day 1) and compared to pre booster vaccination (Day 202)
|
Day 202, Day 382
|
GMFI of HI antibodies against H5N6 strain - Persistence
Time Frame: Day 202
|
GMFI (HI) 6 months post 2nd priming vaccination compared to prevaccination
|
Day 202
|
Percentages of subjects with HI titers ≥1:40 against H5N8 strain - Persistence
Time Frame: Day 202, Day 382
|
% ≥1:40 (HI) 6 months post 2nd priming vaccination and 6 months post booster vaccination
|
Day 202, Day 382
|
Percentages of subjects with HI titers ≥1:40 against H5N6 strain - Persistence
Time Frame: Day 202
|
% ≥1:40 (HI) 6 months post 2nd priming vaccination
|
Day 202
|
Percentages of subjects with seroconversion by HI against H5N8 strain - Persistence
Time Frame: Day 202, Day 382
|
% seroconversion (HI) 6 months post 2nd priming vaccination and 6 months post booster vaccination, defined as a ≥4-fold increase in HI titer postvaccination in those with pre-vaccination titer ≥1:10, or a postvaccination HI titer ≥1:40 for subjects with prevaccination titer <1:10
|
Day 202, Day 382
|
Percentages of subjects with seroconversion by HI against H5N6 strain - Persistence
Time Frame: Day 202
|
% seroconversion (HI) 6 months post 2nd priming vaccination, defined as a ≥4-fold increase in HI titer postvaccination in those with pre-vaccination titer ≥1:10, or a postvaccination HI titer ≥1:40 for subjects with prevaccination titer <1:10
|
Day 202
|
GMT of microneutralization (MN) antibodies against H5N8 strain
Time Frame: Day 1, Day 22, Day 43, Day 202, Day 223
|
GMT (MN) prevaccination, 3 weeks post priming vaccinations, pre booster vaccination and 3 weeks post booster vaccination
|
Day 1, Day 22, Day 43, Day 202, Day 223
|
GMT of MN antibodies against H5N6 strain
Time Frame: Day 1, Day 43, Day 202, Day 223
|
GMT (MN) prevaccination, 3 weeks post 2nd priming vaccination, pre booster vaccination and 3 weeks post booster vaccination
|
Day 1, Day 43, Day 202, Day 223
|
GMFI of MN antibodies against H5N8 strain
Time Frame: Day 22, Day 43, Day 202, Day 223
|
GMFI (MN) 3 weeks post priming vaccinations and 6 months post 2nd priming vaccination compared to prevaccination (Day 1), and 3 weeks post booster vaccination compared to pre booster vaccination (Day 202)
|
Day 22, Day 43, Day 202, Day 223
|
GMFI of MN antibodies against H5N6 strain
Time Frame: Day 43, Day 202, Day 223
|
GMFI (MN) 3 weeks and 6 months post 2nd priming vaccination compared to prevaccination (Day 1), and 3 weeks post booster vaccination compared to pre booster vaccination (Day 202)
|
Day 43, Day 202, Day 223
|
Percentages of subjects with MN titers ≥1:40 against H5N8 strain
Time Frame: Day 1, Day 22, Day 43, Day 202, Day 223
|
% ≥1:40 (MN) prevaccination, 3 weeks post priming vaccinations, pre booster vaccination, and 3 weeks post booster vaccination
|
Day 1, Day 22, Day 43, Day 202, Day 223
|
Percentages of subjects with MN titers ≥1:40 against H5N6 strain
Time Frame: Day 1, Day 43, Day 202, Day 223
|
% ≥1:40 (MN) prevaccination, 3 weeks post 2nd priming vaccination, pre booster vaccination, and 3 weeks post booster vaccination
|
Day 1, Day 43, Day 202, Day 223
|
Percentages of subjects with seroconversion by MN against H5N8 strain
Time Frame: Day 22, Day 43, Day 202, Day 209, Day 223
|
% seroconversion (MN) 3 weeks post priming vaccinations, pre booster vaccination, and 3 weeks post booster vaccination, defined as a ≥4-fold increase in MN titer postvaccination for subjects with prevaccination titer ≥lower limit of quantification (LLOQ), or a postvaccination MN titer ≥4×LLOQ for subjects with prevaccination titer <LLOQ
|
Day 22, Day 43, Day 202, Day 209, Day 223
|
Percentages of subjects with seroconversion by MN against H5N6 strain
Time Frame: Day 43, Day 202, Day 209, Day 223
|
% seroconversion (MN) 3 weeks post 2nd priming vaccination, pre booster vaccination, and 3 weeks post booster vaccination, defined as a ≥4-fold increase in MN titer postvaccination for subjects with prevaccination titer ≥lower limit of quantification (LLOQ), or a postvaccination MN titer ≥4×LLOQ for subjects with prevaccination titer <LLOQ
|
Day 43, Day 202, Day 209, Day 223
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Study Chair: Therapeutic Area Head, Seqirus
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- V205_01
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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