Common and Differentiated Representations Between Social Exclusion and Social Separation

Explore the shared or separated neural mechanisms of social exclusion and social segregation and compare differential effects of AVP and OXT on these social interaction function.

Study Overview

• Status: Recruiting
• Conditions: Healthy
• Intervention / Treatment: Drug: Intranasal Oxytocin; Drug: Intranasal Arginine Vasopressin; Drug: Intranasal placebo

Detailed Description

A large body of research has shown that there are differences in the neural representation between social exclusion and social segregation, but the results are inconsistent, and the exploration of the neural basis is still insufficient. In addition, there are two mainstream theoretical explanations for these differences, namely the construction-level theory and the emotion-based theory, but there is no consistent theoretical model yet. Therefore, further exploration is necessary to confirm the cognitive and neural mechanisms underlying the differences between social exclusion and social segregation, and to attempt to reveal the theoretical explanations for these differences. In this project, the investigators propose to perform behavioral and functional magnetic resonance imaging (fMRI) techniques to examine the shared or separate neural mechanisms of social exclusion and social segregation (exp 1: social exclusion; exp 2: social separation) and investigate the modulatory effects of OXT/AVP on them (PLC/24IU OXT/20IU AVP).

• Study Type: Interventional
• Enrollment (Estimated): 120
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Keith M Kendrick, Dr; Phone Number: +86-28-61830811; Email: k.kendrick.uestc@gmail.com
• Study Contact Backup: Name: Weihua Zhao, Dr; Phone Number: +8618780247797; Email: zarazhao@uestc.edu.cn

Study Locations

• China
  • Sichuan
    • Chengdu, Sichuan, China
      • Recruiting
      • University of Electronic Science and Technology of China(UESTC)

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

1. Healthy subjects;
2. Without any past or present psychiatric or neurological disorders;
3. Without any current psychotherapeutic medication.

EXclusion Criteria:

1. With any past or present psychiatric or neurological disorders;
2. With any current psychotherapeutic medication.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Triple

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Intranasal Oxytocin; Administer oxytocin (24 IU) intranasally.	Drug: Intranasal Oxytocin; Administer oxytocin (24 IU) intranasally, 6 individual 0.1 ml puffs (4 IU/0. 1ml), three puffs per nostril one every 30 seconds.
Active Comparator: Intranasal Arginine Vasopressin; Administer Arginine Vasopressin (20 IU) intranasally.	Drug: Intranasal Arginine Vasopressin; Administer arginine vasopressin (20 IU) intranasally, 6 individual 0.1 ml puffs (3.33 IU/0. 1ml), three puffs per nostril one every 30 seconds.
Placebo Comparator: Intranasal placebo; Administer placebo intranasally.	Drug: Intranasal placebo; Administer placebo intranasally, 6 individual 0.1 ml puffs, three puffs per nostril one every 30 seconds.
No Intervention: Intranasal nothing (control); Control condition

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Neural index: OXT and AVP effects on fMRI based- social exclusion and social separation tasks	Comparions between OXT and AVP on social exclusion and social separation on brain activity or representations	45 minutes after treatment administration
Behavioral index: behavioral ratings of social exclusion and social separation tasks	Comparions between social exclusion and social separation in pain ratings	Immediately after fMRI scanning

Collaborators and Investigators

• Sponsor: University of Electronic Science and Technology of China
• Investigators: Study Chair: Siying Wang, Dr, University of Electronic Science and Technology of China

Study record dates

Study Major Dates

• Study Start (Actual): April 20, 2023
• Primary Completion (Estimated): September 20, 2023
• Study Completion (Estimated): October 1, 2023

Study Registration Dates

• First Submitted: June 2, 2023
• First Submitted That Met QC Criteria: June 16, 2023
• First Posted (Actual): June 27, 2023

Study Record Updates

• Last Update Posted (Actual): June 28, 2023
• Last Update Submitted That Met QC Criteria: June 27, 2023
• Last Verified: June 1, 2023

More Information

Terms related to this study

• Keywords: Oxytocin; fMRI; Arginine Vasopressin; Social exclusion; Social separation
• Additional Relevant MeSH Terms: Physiological Effects of Drugs; Natriuretic Agents; Hemostatics; Coagulants; Reproductive Control Agents; Oxytocics; Vasoconstrictor Agents; Antidiuretic Agents; Oxytocin; Vasopressins; Arginine Vasopressin
• Other Study ID Numbers: UESTC-neuSCAN-93

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No