Outcomes After Visceral Aortic Coral Reef Surgery

Long Term Outcomes After Visceral Aortic Endarteriectomy for Coral Reef Lesion

Coral reef aorta is defined by a calcified stenosis of the visceral aorta which can cause leg claudication, renal failure and visceral ischemia depending the type and localisation of the stenosis.

This pathology is rare and is usually treated by open surgery with aortic endarteriectomy. Little is know about the outcomes after such aggressive surgery with short series and short follow up.

The authors propose a retrospective study from their institution to explore the post operative and long term outcomes after this surgery.

Study Overview

• Status: Completed
• Conditions: Aortic Coral Reef
• Intervention / Treatment: Procedure: Aortic endarteriectomy

Detailed Description

Coral reef aorta is defined by a calcified stenosis of the visceral aorta which can cause leg claudication, renal failure and visceral ischemia depending the type and localisation of the stenosis.

This pathology is rare and is usually treated by open surgery with aortic endarteriectomy.

Little is known in the literature regarding the outcomes of this aggressive surgery.

The authors propose a retrospective study from their institution describing the type of surgery realised. They describe the post operative outcomes of this surgery in term of cardiologic, respiratory, renal complication a,d surgical complication.

Moreover they follow the patients to present long term outcomes of this pathology with a description of the post operative recurrence of a coral reef, the permeability of the different target vessel and the cardiologic, respiratory and renal evolution of the different patients.

• Study Type: Observational
• Enrollment (Actual): 40

Contacts and Locations

Study Locations

• France
  • Toulouse, France, 31059
    • Hostalrich Aurélien

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

All patients who needed a coral reef surgery were included

Description

Inclusion Criteria:

• Coral reef surgery
• Urgent intervention
• Claudication, renal, visceral involvement
• Thoracic aortic cross clamping (above coeliac trunk)

Exclusion Criteria:

• "simple" visceral aorto thrombectomy without opening laterally the aorta
• Pregnant

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Major adverse cardiac event (MACE)	Post operative cardiologic complication	1 month after surgery
Reintervention	Need of reintervention before discharge	1 month after surgery

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Long term follow up	Cumulative survival rate	1 month, 1 year, yearly up to 5 years
Target vessel patency	Permeability of the different vessel (renal and visceral arteries) on CT scan or Duplex ultrasound	1 month, 1 year, yearly up to 5 years
Kidney function evolution	glomerular filtration rate evolution,	1 month, 1 year, yearly up to 5 years

Collaborators and Investigators

• Sponsor: University Paul Sabatier of Toulouse

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2018
• Primary Completion (Actual): January 1, 2023
• Study Completion (Actual): July 1, 2023

Study Registration Dates

• First Submitted: July 19, 2023
• First Submitted That Met QC Criteria: August 6, 2023
• First Posted (Actual): August 9, 2023

Study Record Updates

• Last Update Posted (Actual): August 9, 2023
• Last Update Submitted That Met QC Criteria: August 6, 2023
• Last Verified: August 1, 2023

More Information

Terms related to this study

• Other Study ID Numbers: Long term Coral Reef

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No