The Relationship of DASH and Mediterranean Diet Score With Serum Adiponectin Levels in Patients With Spinal Cord Injury

The aim of this study is to reveal the relationship of DASH and Mediterranean diet score with anthropometric measurements and serum adiponectin level in individuals with spinal cord injury. This research was planned as a cross-sectional, case-control study. With the data to be obtained from the research, information will be obtained about the hormonal or biochemical basis of metabolic disorders such as atherosclerosis and insulin resistance that may occur in individuals with spinal cord injury in the long term.

20 individuals with Spinal Cord Injury will be included in the study, and the results of the patients will be compared with 20 healthy individuals. In order to determine the food consumption status of the patients, a 1-day food consumption record will be requested. DASH diet score and Mediterranean diet score will be calculated from dietary records. After 8 hours of fasting, 3 ml of peripheral blood will be taken for the measurement of adiponectin between 08:00 and 09:00 in the morning from the individuals in the study and control groups. Adiponectin level will be measured and its correlation with DASH diet score and Mediterranean diet score will be examined.

Study Overview

• Status: Completed
• Conditions: Spinal Cord Injuries
• Intervention / Treatment: Other: Keeping a 1-day food consumption record by the patient; Other: Measurement of adiponectin level

• Study Type: Observational
• Enrollment (Actual): 66

Contacts and Locations

Study Locations

• Turkey
  • Ankara, Turkey
    • Ankara Bilkent City Hospital Physical Treatment and Rehabilitation Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

Patients admitted to hospital Healthy population from patient care givers of hospital staff

Description

Inclusion Criteria:

• Inclusion criteria (Study group)

  • Having spent at least 6 months after spinal cord injury
  • 1st motor neuron injury
  • Being between the ages of 18-65
  • Giving consent to participate in the study Inclusion criteria (Control group)
  • Being between the ages of 18-65
  • Giving consent to participate in the study

Exclusion Criteria:

• Exclusion criteria (Study group)

  • Having an additional disease to the spinal cord injury
  • Having a 2nd motor neuron lesion

Exclusion criteria (Control group)

• Having any disease

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Healthy group	Other: Keeping a 1-day food consumption record by the patient; Checking and receiving the 1-day food consumption record recorded by the patient by the researcher; Other: Measurement of adiponectin level; Adiponectin level will be measured for each group
Patients with spinal cord injury	Other: Keeping a 1-day food consumption record by the patient; Checking and receiving the 1-day food consumption record recorded by the patient by the researcher; Other: Measurement of adiponectin level; Adiponectin level will be measured for each group

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Adiponectin level	Adiponectin level will be measured from peripheral blood	Will be measured at inclusion
DASH diet score	Will be measured at inclusion from one day dietary record	Will be measured at inclusion from one day dietary record
Mediterrenian diet score	Will be measured at inclusion from one day dietary record	Will be measured at inclusion from one day dietary record

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Whole blood count	Will be measured at inclusion	Will be measured at inclusion
Fasting blood glucose	Will be measured at inclusion	Will be measured at inclusion
Total cholesterol	Will be measured at inclusion	Will be measured at inclusion
LDL	Will be measured at inclusion	Will be measured at inclusion
HDL	Will be measured at inclusion	Will be measured at inclusion
TG	Will be measured at inclusion	Will be measured at inclusion

Collaborators and Investigators

• Sponsor: Ankara City Hospital Bilkent

Publications and helpful links

General Publications

• Ekmekci H, Ekmekci OB. The role of adiponectin in atherosclerosis and thrombosis. Clin Appl Thromb Hemost. 2006 Apr;12(2):163-8. doi: 10.1177/107602960601200203.
• O'Brien LC, Graham ZA, Chen Q, Lesnefsky EJ, Cardozo C, Gorgey AS. Plasma adiponectin levels are correlated with body composition, metabolic profiles, and mitochondrial markers in individuals with chronic spinal cord injury. Spinal Cord. 2018 Sep;56(9):863-872. doi: 10.1038/s41393-018-0089-8. Epub 2018 Mar 20.
• Wang YH, Huang TS, Liang HW, Su TC, Chen SY, Wang TD. Fasting serum levels of adiponectin, ghrelin, and leptin in men with spinal cord injury. Arch Phys Med Rehabil. 2005 Oct;86(10):1964-8. doi: 10.1016/j.apmr.2005.04.017. Erratum In: Arch Phys Med Rehabil. 2007 May;88(5):688.

Study record dates

Study Major Dates

• Study Start (Actual): March 1, 2021
• Primary Completion (Actual): March 1, 2022
• Study Completion (Actual): March 1, 2022

Study Registration Dates

• First Submitted: August 10, 2023
• First Submitted That Met QC Criteria: August 10, 2023
• First Posted (Actual): August 18, 2023

Study Record Updates

• Last Update Posted (Actual): August 18, 2023
• Last Update Submitted That Met QC Criteria: August 10, 2023
• Last Verified: August 1, 2023

More Information

Terms related to this study

• Keywords: Adiponectin
• Additional Relevant MeSH Terms: Central Nervous System Diseases; Nervous System Diseases; Trauma, Nervous System; Spinal Cord Diseases; Wounds and Injuries; Spinal Cord Injuries
• Other Study ID Numbers: E2-21-89

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No