- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06131216
Phase I Study of SHR-2022 Injection in the Treatment of Patients With Advanced Malignant Tumors
November 8, 2023 updated by: Suzhou Suncadia Biopharmaceuticals Co., Ltd.
Phase I Clinical Study on the Safety, Tolerability, Pharmacokinetics and Efficacy of SHR-2022 Injection Alone or in Combination With Other Anti-tumor Treatments in Patients With Advanced Malignant Tumors
To evaluate the safety and tolerability of SHR-2022 in patients with advanced malignancies and to determine MTD or MAD versus RP2D
Study Overview
Status
Not yet recruiting
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Estimated)
116
Phase
- Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Yanbo Liu
- Phone Number: 0518-82342973
- Email: yanbo.liu@hengrui.com
Study Contact Backup
- Name: Zhenqun Lu
- Phone Number: 0518-82342973
- Email: zhenqun.lu@hengrui.com
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
- Voluntary participation in this study, signed informed consent, compliance is good, can cooperate with follow-up
- Age 18-80 years old (including both ends), both male and female
- Subjects with advanced or metastatic malignant tumors confirmed by pathological tissue or cytology, and who have failed previous standard treatments, are intolerant to standard treatments, or have no standard treatments
- Have measurable lesions
- ECOG PS score: 0-1
- Have a life expectancy of at least 3 months
- The functional level of the major organs must meet the requirements
- Fertile female patients must have a serum pregnancy test within 7 days before the first medication and the result is negative; And must be non-lactating
Exclusion Criteria:
- Central nervous system metastasis or meningeal metastasis with clinical symptoms
- Spinal cord compression that has not been treated radically by surgery and/or radiotherapy
- Patients with uncontrolled tumor-related pain as judged by the investigator
- A third space effusion with uncontrolled pleural effusion, pericardial effusion, or peritoneal effusion, as determined by the investigator
- Systemic antitumor therapy was administered within 28 days prior to treatment in the first study
- Surgical procedures requiring tracheal intubation and general anesthesia were performed within 28 days prior to the initial study, diagnostic or superficial surgery was performed within 7 days prior to the initial study, or elective surgery was expected during the trial period
- Received within 28 days prior to the first investigational dose Non-radical chest radiation therapy of 30Gy received within 24 weeks prior to initial dosing. Patients receiving 30Gy of chest radiation therapy, and those receiving palliative radiation ≤30Gy within 14 days prior to the first dose
- The AE caused by previous anti-tumor therapy did not recover to CTCAE v5.0 grade evaluation ≤1
- Live attenuated vaccines were used within 28 days prior to administration in the first study or were expected to be required during the study treatment
- Systemic immunosuppressive therapy was administered within 14 days prior to the first study
- Accompanied by interstitial pneumonia or interstitial lung disease
- Patients with a history of autoimmune disease
- The first study studied patients with clinically significant bleeding symptoms or bleeding tendency within 3 months before medication
- The first study was conducted in subjects with severe cardiovascular and cerebrovascular disease within 6 months prior to medication
- Arterial/venous thrombosis events occurred within 3 months prior to initial administration
- The first study studied any other malignancy within 5 years prior to medication
- A known history of severe allergic reactions to the investigational drug and its principal formulation ingredients
- Have a history of immune deficiency or organ transplantation, and have active hepatitis B or C
- Severe infection within 4 weeks prior to the first dose
- Patients with active pulmonary tuberculosis within 1 year prior to enrollment were found by history or CT examination
- The presence of other serious physical or mental illness, known alcohol or drug dependence, abnormal laboratory tests, and other factors that may increase the risk of participating in the study or interfere with the study results; And any other conditions that the investigator deems inappropriate for participation in this study
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: SHR-2022 Injection
|
SHR-2022 Injection is administered by intravenous (IV) infusion
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Incidence of adverse events
Time Frame: up to 3 years
|
up to 3 years
|
MTD
Time Frame: up to 3 years
|
up to 3 years
|
RP2D
Time Frame: up to 3 years
|
up to 3 years
|
Severity of adverse events
Time Frame: up to 3 years
|
up to 3 years
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Time to maximum concentration (Tmax)
Time Frame: up to 3 year
|
up to 3 year
|
Maximum concentration (Cmax)
Time Frame: up to 3 year
|
up to 3 year
|
Receptor Occupancy(OR) of SHR-2022
Time Frame: up to 3 year
|
up to 3 year
|
Anti-drug antibody (ADA) of SHR-2022
Time Frame: up to 3 year
|
up to 3 year
|
Objective response rate (ORR)
Time Frame: up to 3 year
|
up to 3 year
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Estimated)
December 1, 2023
Primary Completion (Estimated)
December 1, 2026
Study Completion (Estimated)
December 1, 2026
Study Registration Dates
First Submitted
November 8, 2023
First Submitted That Met QC Criteria
November 8, 2023
First Posted (Estimated)
November 14, 2023
Study Record Updates
Last Update Posted (Estimated)
November 14, 2023
Last Update Submitted That Met QC Criteria
November 8, 2023
Last Verified
November 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- SHR-2022-I-101
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
UNDECIDED
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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