Cohort in Qianwan New District, Ningbo

Prevention and Control of Chronic Noncommunicable Diseases in Natural Population in Qianwan New District, Ningbo

Our objective is to carry out research on prevention and control of noncommunicable chronic diseases, and establish a risk prediction mechanism for chronic diseases to promote early detection, early diagnosis and early treatment of chronic diseases in natural population in Qianwan District of Ningbo, significantly reduce medical costs and extend population life span.

Study Overview

• Status: Recruiting
• Conditions: Cardiovascular Diseases; Stroke; Non-Communicable Chronic Diseases

Detailed Description

1. Through baseline survey (cross-sectional survey) and prospective cohort design, the health status information and biological samples of residents in Hangzhou Bay Hospital were collected, and the physical, psychological and social adaptability information was collected through questionnaires and other forms, basic tests and omics measurements were carried out based on the collected samples to build a multi-dimensional data platform.

2. Develop a disease risk prediction model based on big data platform, conduct high-risk population screening and establish risk assessment files; In view of the common health problems in the study population, the key factors and effects of health status were analyzed comprehensively, and the corresponding mathematical model was established to form the prediction of health status. Finally to establish the stratified standard of population health status and provide effective health guidance.

   Questionnaire survey on epidemiology: The Hangzhou Bay Natural Population Cohort Questionnaire was designed according to the principles and requirements of cohort study. All respondents who entered the cohort will sign informed consent, receive face-to-face interview with uniformly trained investigators, and the questionnaire will be reviewed by quality control personnel for quality control.

   Physical examination: The examination contents include height, weight, blood pressure, waist circumference, hip circumference, hearing, vision, medical history and surgery, inbody composition, chest film, electrocardiogram, B-ultrasound, non-invasive arteriosclerosis examination, vascular endothelial ultrasound and other imaging examinations.

   Clinical biochemical test: 5-10 ml of blood, 20 ml of urine and 5 g of feces were collected (if necessary) according to the chronic non-communicable disease spectrum and clinical test requirements in Qianwan New District of Ningbo; The blood samples and urine were tested for biochemistry, liver and kidney function, blood lipids and electrolytes according to clinical testing requirements, as well as multi-omics indicators as needed.

3. Prospective study data: Follow-up of the cohort population (disease occurrence, death, migration, etc.) was conducted through annual active follow-up (telephone, interview, etc.) and passive follow-up, including data of all-cause death, incidence of any kind of diseases.

• Study Type: Observational
• Enrollment (Estimated): 30000

Contacts and Locations

• Study Contact: Name: Jun Pu, MD, PhD; Phone Number: 86-21-68383477; Email: pujun310@hotmail.com
• Study Contact Backup: Name: Wei Zhang, PhD; Phone Number: 86-13761780922; Email: zhangwei050080@renji.com

Study Locations

• China
  • Shanghai, China
    • Recruiting
    • Ren Ji Hospital Afflited to School of Medicine, Shanghai Jiao Tong University
    • Contact: Jun Pu, MD,PHD; Phone Number: 86-21-68383477; Email: pujun310@hotmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

Relying on the manufacturing factories gathered around Hangzhou Bay Hospital, a relatively stable cohort of participants was provided. According to the entry criteria, eligible subjects were selected to be included in the Hangzhou Bay natural population cohort.

Description

Inclusion Criteria:

• 1) Local permanent residents aged 18 and above (including residents with household registration, or residents without household registration but with a permanent job);
• 2) No serious physical disability, can communicate normally;
• 3) Participate voluntarily and sign informed consent.

Exclusion Criteria:

• 1) Temporary resident and floating population;
• 2) There are serious health conditions unable to participate in the survey;
• 3) Those who are unwilling to accept the follow-up inspection of the project.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
death	Mortality of all-cause disease were calculated by age, gender and area compared by different health management mode.	4 years
incidence of cardio-cerebrovascular diseases	Incidence of Cardiovascular and Cerebrovascular diseases were calculated by age, gender and area compared by different health management mode.	4 years
incidence of other non-communicable chronic diseases	Incidence of other non-communicable chronic diseases were calculated by age, gender and area compared by different health management mode.	4 years

Collaborators and Investigators

• Sponsor: RenJi Hospital
• Collaborators: Ningbo Hangzhou Bay Hospital
• Investigators: Principal Investigator: Jun Pu, MD, PhD, Ningbo Hangzhou Bay Hospital

Study record dates

Study Major Dates

• Study Start (Actual): November 1, 2023
• Primary Completion (Estimated): June 30, 2027
• Study Completion (Estimated): June 30, 2027

Study Registration Dates

• First Submitted: April 18, 2024
• First Submitted That Met QC Criteria: April 25, 2024
• First Posted (Actual): April 29, 2024

Study Record Updates

• Last Update Posted (Actual): April 29, 2024
• Last Update Submitted That Met QC Criteria: April 25, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Keywords: cohort; natural population; Non-communicable Chronic Disease
• Additional Relevant MeSH Terms: Pathologic Processes; Disease Attributes; Cardiovascular Diseases; Chronic Disease; Noncommunicable Diseases
• Other Study ID Numbers: Hangzhou Bay Cohort

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No