Early Surgical Effects and Influencing Factors of High Tibial Osteotomy in the Treatment of Knee Osteoarthritis

Exploring the factors influencing postoperative functional recovery after high tibial osteotomy

Study Overview

• Status: Completed
• Conditions: Osteoarthritis, Knee
• Intervention / Treatment: Procedure: High tibial osteotomy

Detailed Description

A retrospective study was conducted on patients who underwent HTO at the First Affiliated Hospital of Shandong First Medical University from January 2018 to December 2020, and the preoperative and postoperative imaging indicators [medial proximal tibial angle (MPTA), joint line intersection angle (JLCA), hip-knee-ankle angle (HKA angle), knee weight-bearing line percentage (WBL%), postoperative distraction distance, postoperative distraction angle] and knee joint function score [including the American Hospital for Special Surgery (HSS) knee score, American Knee Society score (KSS), Lysholm score, Western Ontario and McMaster Universities Osteoarthritis Index score (WOMAC), and all were included in logistic regression analysis to study the surgical effect and impact of HTO factor

• Study Type: Observational
• Enrollment (Actual): 78

Contacts and Locations

Study Locations

• China
  • Shandong
    • Jinan, Shandong, China, 270000
      • The First Affiliated Hospital of Shandong First Medical University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

The study subjects were patients who underwent medial open HTO for KOA at the First Affiliated Hospital of Shandong First Medical University from January 2018 to December 2020. This article included a total of 45 patients with grade II and grade III according to the Kellgren-Lawrence arthritis classification. There were 28 cases, including 5 grade IV patients.

Description

Inclusion Criteria:

• Medial knee OA, varus deformity is mainly in the tibia
• Aged ≤70 years old, with higher requirements for future activities
• Knee joint extension is limited to ≤10°, and flexion is >90°
• Body Mass Index (BMI) ≤ 40
• No subchondral bone wear

Exclusion Criteria:

• There is a history of fracture or surgery of the lower limb on the operated side
• Traumatic KOA
• Combined with nerve, muscle or connective tissue diseases
• Incomplete imaging data and loss of follow-up

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Logistics regression model; This article is a retrospective study, which mainly incorporates patients' preoperative and postoperative imaging parameters and demographic data into Logistics regression analysis to analyze factors that may affect the surgical effect. No interventions such as medication are involved.	Procedure: High tibial osteotomy; Surgical treatment for patients with osteoarthritis and indications for high tibial osteotomy

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Imaging parameters	Medial proximal tibial angle	an average of 1 year after the surgery
Imaging parameters	Opening gap	an average of 1 year after the surgery
Imaging parameters	the weight bearing line ratio	an average of 1 year after the surgery
Imaging parameters	joint line convergence angle	an average of 1 year after the surgery
Imaging parameters	Hip-knee-ankle	an average of 1 year after the surgery
Imaging parameters	opening angle	an average of 1 year after the surgery

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
function score	the US Hospital for special surgery knee-rating score	an average of 1 year after the surgery
function score	American knee society knee score	an average of 1 year after the surgery
function score	Lysholm	an average of 1 year after the surgery
function score	Western Ontario and McMaster Universities Osteoarthritis Index	an average of 1 year after the surgery

Collaborators and Investigators

• Sponsor: Shufeng Li
• Investigators: Study Director: Zhang Zhao, professor, The First Affiliated Hospital of Shandong First Medical University

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2021
• Primary Completion (Actual): December 1, 2021
• Study Completion (Actual): December 1, 2021

Study Registration Dates

• First Submitted: January 4, 2024
• First Submitted That Met QC Criteria: July 16, 2024
• First Posted (Actual): July 22, 2024

Study Record Updates

• Last Update Posted (Actual): July 22, 2024
• Last Update Submitted That Met QC Criteria: July 16, 2024
• Last Verified: July 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Arthritis; Osteoarthritis; Osteoarthritis, Knee
• Other Study ID Numbers: 0000-0001-6044-0655

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No