Undersøgelse af funktionelt hjernenetværk i ændret meditationstilstand med multimodal neuroimaging
21. juli 2026 opdateret af: Shanghai Mental Health Center
Formålet med denne undersøgelse er at undersøge funktionelt hjernenetværk i ændret meditationstilstand med multimodal neuroimaging.
Studieoversigt
Status
Afsluttet
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
- Rekruttering af deltagere ved at henvende sig til mindfulnesstræning, plakat og hjemmesider.
- Udfylde spørgeskemaer, tests og andre materialer til eksperimenter.
- Undersøgelse af funktionelt hjernenetværk af intern og ekstern meditation af praktiserende læger med en meditation ved hjælp af multimodal neuroimaging.
- Indsamling og evaluering af data om sammenhængen mellem intern og ekstern meditation med multimodal neuroimaging og identifikation af funktionen relateret til meditationstilstand.
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
40
Fase
- Ikke anvendelig
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Shanghai Municipality
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Shanghai, Shanghai Municipality, Kina, 200030
- School of Biomedical Engineering, Shanghai Jiao Tong University
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år til 60 år (Voksen)
Tager imod sunde frivillige
Ja
Beskrivelse
Inklusionskriterier:
- Et tilstrækkeligt uddannelsesniveau til at forstå studieproceduren og være i stand til at kommunikere med stedets personale.
- 18-60 år gammel.
- Interesseret i meditation.
- Ingen metal- eller elektroniske implantater i kroppen; ingen proteser (metalbøjler, tandproteser osv.); ingen klaustrofobi; ingen tatoveringer, piercinger osv.; ingen makeup på forsøgsdagen.
- Højrehåndet.
Ekskluderingskriterier:
- Deltageren har kontraindikation til MR-undersøgelse, såsom klaustrofobi.
- Deltageren er fysisk uegnet til MR, såsom at få et metalimplantat.
- Deltageren har en historie med neurologiske eller psykiatriske lidelser eller tager kronisk medicin, der kan forstyrre eksperimentet.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Sundhedstjenesteforskning
- Tildeling: Ikke-randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Dobbelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
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Eksperimentel: Novice meditators
Participants who have no meditation practice in the previous year and less than 20 entire lifetime hours' meditation.
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Undersøgelse af DMN-forbindelse og CSF-flow i ekstern meditationstilstand ved ekstern meditationsinstruktionslyd.
Undersøgelse af DMN-forbindelse og CSF-flow i ekstern meditationstilstand ved intern meditationsinstruktionslyd.
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Eksperimentel: Experienced meditators
Participants with more than two years of mindfulness practice
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Undersøgelse af DMN-forbindelse og CSF-flow i ekstern meditationstilstand ved ekstern meditationsinstruktionslyd.
Undersøgelse af DMN-forbindelse og CSF-flow i ekstern meditationstilstand ved intern meditationsinstruktionslyd.
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Five Facet Mindfulness Questionnaire(FFMQ)
Tidsramme: Week 1
|
FFMQ is a validated, self-administered questionnaire that measures the tendency to act with mindfulness.
Its 39 items are assessed on a Likert scale from 1 to 5 (i.e., "never or very rarely true" to "very often or always true").
The higher scores on the scale convey the higher tendency to act with mindfulness.
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Week 1
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CSF pulsation index
Tidsramme: Week 1
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CSF pulsation index, calculated by the number of CSF pulsation per minute.
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Week 1
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Functional connectivity
Tidsramme: Week 1
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Checking functional connectivity in major resting-state brain networks (such as DMN).
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Week 1
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Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Mindfulness positive awareness examined by Mindful Attention Awareness Scale (MAAS)
Tidsramme: Week 1
|
MAAS is a validated, fifteen-item self-report measure on which the items are scored using a six-point rating scale (1 = almost always and 6 = almost never).
The global score of the scale is obtained by calculating the mean score of each participant's responses, and higher scores on the scale convey the higher levels of dispositional mindfulness.
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Week 1
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The ability of self-compassion examined by Self-Compassion Scale(SCS) after 1-week practice of internal and external mindfulness
Tidsramme: Week 1
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SCS is a validated, 26-item self-report measure on which the items are scored using a five-point Likert scale scored from 1 (almost never) to 5 (almost always).
The higher total score on the scale indicates a higher level of self-compassion.
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Week 1
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Cognitive Flexibility Inventory(CFI)
Tidsramme: Week 1
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CFI is a validated, self-reported measure of cognitive flexibility，which consists of 20 statements scored from 1 ( "definitely disagree") to 7( "definitely agree.").
The scores for all items are pooled to generate a total score of 20 to 140.
Higher total scores indicate the increasing level of cognitive flexibility.
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Week 1
|
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Perceived Stress Scale(PSS)
Tidsramme: Week 1
|
PSS is a validated, self-reported measure of psychological stress level.
There are 10-items scored from 0 (never) to 4 (very often).
The scores for all items are pooled to generate a total score in the range of 0 to 40.
Higher total scores indicate the increasing level of psychological stress.
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Week 1
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The Chinese version of Freiburg Mindfulness Inventory(FMI-13)
Tidsramme: Week 1
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FMI-13 is a validated, thirteen-item self-report measure on which the items are scored using a four-point Likert scale ranging from 1 (strongly disagree) to 4 (strongly agree).
This short form was used for measuring mindfulness traits, and higher scores on the scale convey the higher levels of mindfulness trait.
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Week 1
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Andre resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Cognitive impairment quantitative assessment by Mini-Mental State Examination(MMSE)
Tidsramme: Week 0
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MMSE is a validated, widely used screening tool for cognitive impairment quantitative assessment.
It included 11 items.
The scores for all items are pooled to generate a total score in the range of 0 to 30.
A 27-point was proved to be an appropriate cutoff for cognitive impairment in a population with relatively high educational attainment.
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Week 0
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Intelligence assessment by Raven's Standard Progressive Matrices (SPM)
Tidsramme: Week 0
|
SPM is a validated intelligence assessment that consists of 60 non-colored diagrammatic puzzles with a missing part, which subjects should correctly choose one among six options.
SPM scores were estimated as the total of participants' correct answers (0-60).
Higher total scores indicate the increasing level of intelligence level.
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Week 0
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Brief Profile of Mood States(Brief-POMS)
Tidsramme: Week 1
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The Brief-POMS is a validated,30-item measure, with items scored on a 5-point Likert scale ranging from 0 (not at all) to 4 (extremely).
The scores for all items are pooled to generate a total score in the range of 0 to 120.
A higher total score on the scale indicates a worse mood state.
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Week 1
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Mental flexibility assessment by Trail Making Test (TMT)
Tidsramme: Week 1
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TMT is a validated mental flexibility assessment consisting of two parts (TMT-A and TMT-B ).
The TMT-A consisted of a standardized page on which the numbers 1 to 25 were scattered within circles.
The participants were asked to connect the numbers in order as quickly as possible.
Similarly, the TMT-B consisted of a standardized page that included the numbers 1 to 13 and the letters A to L, which were randomly distributed.
The participants were instructed to draw lines connecting numbers and letters (ascending and alphabetical) in alternating numbers and letters.
A maximum time of 300 s was allowed before discontinuing the test.
Direct scores of TMT were the time in seconds taken to complete each task (A and B).
A Higher result indicates a worse cognitive outcome.
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Week 1
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Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Efterforskere
- Studiestol: Qing Fan, Shanghai Mental Health Center
- Studiestol: Jie Luo, School of Biomedical Engineering, Shanghai Jiao Tong University
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
20. september 2020
Primær færdiggørelse (Faktiske)
30. december 2023
Studieafslutning (Faktiske)
30. december 2023
Datoer for studieregistrering
Først indsendt
14. juli 2021
Først indsendt, der opfyldte QC-kriterier
18. august 2021
Først opslået (Faktiske)
25. august 2021
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
23. juli 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
21. juli 2026
Sidst verificeret
1. juni 2021
Mere information
Begreber relateret til denne undersøgelse
Andre undersøgelses-id-numre
- B20200361
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