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An Attempt at Translating Novelty-enhanced Extinction of Context Conditioning From Rodents to Humans

9. juni 2022 opdateret af: Uppsala University
In rodents, novel exploration has been used to strengthen the consolidation of a variety of hippocampal-dependent learning tasks. To our knowledge, no attempt have been made to translate the effect of strengthening the memory of an extinction of a context conditioning memory. This study uses virtual reality for both context conditioning and novel exploration in an attempt at translating these findings from rodents to humans, thus, using novel exploration to strengthen an extinction memory. Threat responses are measured with skin conductance and startle responses. If this effect could be shown experimentally in humans, that experimental setup could become an important tool in understanding important memory processes of fear, such as reconsolidation and behavioral tagging.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

The study employs healthy participants and includes three experimental sessions, roughly 24 h apart. During the first session, participants undergo context conditioning in virtual reality where the CS+ and CS- are two different rooms. During the second session, half of the participants perform an exploration of a novel virtual environment, and the other half performs a visual attention task. About 60 min later, participants undergo extinction to the context conditioning performed in session 1, again in virtual reality. In session 3, remaining threat responses are measured through a reinstatement procedure, again in virtual reality.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

60

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Sverige
      • Uppsala, Sverige, 75142
        • Uppsala University, deparmtent of Psychology

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år til 50 år (Voksen)

Tager imod sunde frivillige

Ja

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion Criteria:

  • Willing and able to provide informed consent and complete study procedures

Exclusion Criteria:

  • Current psychiatric disorder.
  • Current use of psychotropic medication
  • Current use of neurological conditions

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Grundvidenskab
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Enkelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: Experimental group
Novel exploration is used before extinction in an attempt to strengthen the extinction consolidation.
Adfærdsmæssigt: Novel Exploration
Exploration of a novel 3D-environment in virtual reality.
Adfærdsmæssigt: Threat conditioning
Session 1. Threat conditioning to two different (CS+, CS-) virtual reality contexts (i.e rooms). One of these is paired with a mild electric shock. The context paired with the electric shock (CS+) is counterbalanced across participants. Participants are instructed that they may receive electrical shocks during the procedure.
Adfærdsmæssigt: Extinction
Session 2. Participants are repeatedly exposed to the both contexts from session 1 (CS+, CS-), but no shocks are delivered.
Adfærdsmæssigt: Reinstatement
Session 3. Participants are again repeatedly exposed to both contexts from session 1 (CS+, CS-), after a few shocks delivered in a neutral context.
Eksperimentel: Control group
Participants perform a control task (visual attention) instead of the novel exploration.
Adfærdsmæssigt: Threat conditioning
Session 1. Threat conditioning to two different (CS+, CS-) virtual reality contexts (i.e rooms). One of these is paired with a mild electric shock. The context paired with the electric shock (CS+) is counterbalanced across participants. Participants are instructed that they may receive electrical shocks during the procedure.
Adfærdsmæssigt: Extinction
Session 2. Participants are repeatedly exposed to the both contexts from session 1 (CS+, CS-), but no shocks are delivered.
Adfærdsmæssigt: Reinstatement
Session 3. Participants are again repeatedly exposed to both contexts from session 1 (CS+, CS-), after a few shocks delivered in a neutral context.
Adfærdsmæssigt: Visual attention control task
Session 2. A visual attention task used as a control task instead of novel exploration.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Physiological arousal response during reinstatement.
Tidsramme: Day 3
Startle responses and skin conductance responses are used as measures of physiological arousal response.
Day 3

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Physiological arousal response during extinction
Tidsramme: Day 2
Startle responses and skin conductance responses are used as measures of physiological arousal response
Day 2
Physiological arousal response during threat conditioning
Tidsramme: Day 1
Startle responses and skin conductance responses are used as measures of physiological arousal response
Day 1
Subjective fear ratings
Tidsramme: Day 1, 2 & 3.
Subjective ratings of fear (0-100) where 0 is no fear and 100 is worst imaginable fear.
Day 1, 2 & 3.
Subjective discomfort ratings
Tidsramme: Day 1, 2 & 3
Subjective ratings of discomfort where 0 is no discomfort and 100 is worst imaginable discomfort.
Day 1, 2 & 3

Andre resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Navigation success
Tidsramme: Day 2
Questions designed to probe the amount of navigation performed by participants doing the novel exploration task. Three yes/no question of "Did you find object X?" and then participants are asked to point at their position in a stylized map overviewing the novel exploration context.
Day 2
State-Trait Anxiety Inventory (STAI-T)
Tidsramme: Day 2
This is a self-rated questionnaire measuring trait anxiety. Higher scores indicate higher level of trait-anxiety (range 20-80).
Day 2
Generalized anxiety disorder 7 (GAD-7)
Tidsramme: Day 2
This is a self-rated questionnaire for screening and severity measuring of generalized anxiety disorder (range 0-21). Higher scores indicate more symptoms of generalized anxiety.
Day 2
Patient Health Questionnaire 9 (PHQ-9)
Tidsramme: Day 2
This is a self-rated questionnaire for screening for the presence and severity of depression (0-27). Higher scores indicate a more symptoms, and severity of symptoms, of depression
Day 2

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Uppsala University

Efterforskere

  • Ledende efterforsker: Thomas Ågren, PhD, Uppsala University

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

15. november 2021

Primær færdiggørelse (Faktiske)

1. maj 2022

Studieafslutning (Faktiske)

1. maj 2022

Datoer for studieregistrering

Først indsendt

6. november 2021

Først indsendt, der opfyldte QC-kriterier

26. november 2021

Først opslået (Faktiske)

9. december 2021

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

10. juni 2022

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

9. juni 2022

Sidst verificeret

1. juni 2022

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Andre undersøgelses-id-numre

  • 2021-03596

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

JA

IPD-planbeskrivelse

We plan to share anonymous behavioural data, training material, Statistical Analysis plan, and informed consent form on the project site on Open Science Framework (https://osf.io/4yjev/). Statistical Analysis Plan will be pre-registered on the same site (Open Science Framework).

IPD-delingstidsramme

Data will be available from completion of analysis and publication, and onwards.

IPD-delingsadgangskriterier

Anonymous behavioural data, training material, Statistical Analysis plan, and informed consent form will be made public on the project site on Open Science Framework (https://osf.io/4yjev/)

IPD-deling Understøttende informationstype

  • SAP
  • ICF

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Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Novel Exploration

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