Denne side blev automatisk oversat, og nøjagtigheden af ​​oversættelsen er ikke garanteret. Der henvises til engelsk version for en kildetekst.

Evaluering af sikkerhed og kontrol af nærsynethed Progression ved hjælp af nye brilleglas

15. september 2026 opdateret af: HOYA Lens Thailand LTD.

The goal of this clinical trial is to test Novel spectacle lenses in myopic children. The main question it aims to answer are: safety and efficacy of the lenses. Participants will be asked to wear spectacles and participate in eye exams and questionnaires. Researchers will compare Novel spectacle lenses and general single vision spectacle lenses to see if the Novel spectacle lenses correct myopic ametropia, slow the progression of myopia and axial elongation.

Studieoversigt

Detaljeret beskrivelse

This is a 3-year prospective, multicenter, randomized, and single-masked*, parallel-group controlled clinical study. The purpose of this study is to evaluate the safety and efficacy of wearing Novel spectacle lenses to correct myopic ametropia, slow the progression of myopia and axial elongation in myopic children as compared to the use of single vision spectacles lenses.

The treatment arms are:

  • Model A Novel spectacle lens
  • Model B Novel spectacle lens
  • Single vision spectacle lens

Single-masked:

The investigator responsible for conducting ocular data measurements related to the primary and secondary endpoints will be masked. The participants will not be informed the treatment arm during the clinical trial.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

249

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

      • Beijing, Kina
        • Beijing Tongren Hospital, Capital Medical University
      • Guangzhou, Kina
        • Guangzhou Aier Eye Hospital
      • Shanghai, Kina
        • Eye and ENT Hospital of Fudan University
      • Shengyang, Kina
        • Shengyang He Eye Specialist Hospital
      • Tianjin, Kina
        • Tianjin Medical University Eye Hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

7 år til 13 år (Barn)

Tager imod sunde frivillige

Ja

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion Criteria:

  1. Participant and parent (or guardian) are able and willing to provide consent
  2. Participant and parent (or guardian) ensure to attend required study visits and adhere to participant requirements
  3. Parent or guardian understands and accepts random allocation of grouping, and that participant and parent (or guardian) will not be told which group participant is allocated to
  4. Participant willing to wear the study spectacles lens for a minimum of 12 hours per day for the duration of the study
  5. Age at time of parent or guardian consent and participant assent: 7 - 13 years old
  6. Spherical equivalent cycloplegic autorefraction: -1.00 to -7.00 D in each eye.
  7. Cycloplegic autorefraction astigmatism of 1.50 D or less in each eye
  8. Cycloplegic autorefraction anisometropia of 1.50 D or less
  9. Monocular best corrected distance visual acuity (BCDVA) equal to or better than logMAR 0.10 in each eye.

Exclusion Criteria:

  1. Participant is allergy to fluorescein, benoxinate, proparacaine, tropicamide or cyclopentolate eye drops
  2. Any ocular and systemic abnormalities might be expected to affect visual functions or refractive development
  3. (a) Have received treatment of myopic control pharmaceutical medication (e.g., atropine) or light fundus illuminance therapy (e.g., repeated red light therapy) within 6 months prior to entry into this study. (b) Have received treatment of myopia control such as contact lenses, orthokeratology lenses etc., progressive addition lenses, bifocal lenses, within 3 months. (c) Have received treatment of myopia control such as defocus spectacle lenses (difference between both eye's non-cycloplegic autorefraction and lens-meter results of the respective lenses are equal or less than 0.50 D SER) etc. within one month prior to entry into this study.
  4. Participant with clinically significant strabismus (including intermittent tropia)
  5. Medical history of binocular vision abnormalities
  6. Participant with amblyopia
  7. Participation in a clinical trial within 30 days prior to entry into this study or during participation
  8. Previous intraocular surgery
  9. Participant who, in the judgment of the Investigator, presence of any emotional, physiologic, or anatomical condition which may preclude participation in this study or provide an inappropriate landscape for the intended study treatment.
  10. Any medical treatment or medication which might have an influence on vision or interfere with study assessments
  11. Pathological myopia (myopia that leads to structural changes in the posterior segment of the eye including posterior staphyloma, myopic maculopathy, and high myopia-associated optic neuropathy)

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Enkelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: Model-A Novel brilleglas

Model-A Novel spectacle lenses will be given to 1 arm to wear for 36 months

Eksperimentel: Model-B Novel brilleglas

Model-B Novel spectacle lenses will be given to 1 arm to wear for 36 months

Andet: Single Vision brilleglas

Single Vision Spectacle lenses will be given to 1 arm to wear for 36 months

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Axial length
Tidsramme: 24 months

The difference of Axial length changes over 24 months between treatment groups in low and moderate myopia (-1.00 D to -5.00 D) participants.

24 months
Spherical equivalent cycloplegic autorefraction
Tidsramme: 24 months

The difference of spherical equivalent cycloplegic autorefraction changes over 24 months between treatment groups in low and moderate myopia (-1.00 D to -5.00 D) participants

24 months

Sekundære resultatmål

Resultatmål
Tidsramme
Aksial længde
Tidsramme: 36 måneder
36 måneder
Sfærisk ækvivalent cykloplegisk autorefraktion
Tidsramme: 36 måneder
36 måneder

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

31. juli 2023

Primær færdiggørelse (Faktiske)

25. juli 2026

Studieafslutning (Anslået)

31. maj 2027

Datoer for studieregistrering

Først indsendt

23. maj 2023

Først indsendt, der opfyldte QC-kriterier

23. maj 2023

Først opslået (Faktiske)

2. juni 2023

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

18. september 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

15. september 2026

Sidst verificeret

1. marts 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • DG2-3A

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ingen

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Abonner