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Brain Oscillations and Neural States (PHAROS)

3. juni 2026 opdateret af: IRCCS San Camillo, Venezia, Italy

Relationship Between Brain Oscillations and Neural States

The study aims to investigate, through the use of electroencephalography (EEG), instantaneous brain states, namely rapid oscillations of the brain's electrical activity, and their relationship with behavior and brain functions. The study will focus on three main objectives: (1) establishing a relationship between brain oscillations and behavior; (2) establishing a relationship between brain oscillations and brain functions, in terms of neural responsiveness; and (3) identifying the different phases of brain oscillations and investigating any related modulations of behavior and brain functions.

PHAROS will combine EEG with transcranial magnetic stimulation (TMS) to investigate and modulate brain states non-invasively.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

30

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Italien
      • Venice-Lido, Italien
        • IRCCS San Camillo Hospital, Venice, Italy

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ja

Beskrivelse

Inclusion Criteria:

  • Healthy adults

Exclusion Criteria:

  • Left-handedness (assessed through the Oldfield test)
  • Diagnosis of neurological or psychiatric disorders
  • Vision problems that prevent reading, not correctable with lenses
  • Diagnosis of substance dependence on drugs or alcohol
  • Presence of hearing aids/prostheses
  • Diagnosis of epilepsy or family history up to the second degree with it
  • Episodes of febrile convulsions or recurrent fainting
  • Head trauma
  • Presence of surgical clips or metal implants in the head
  • Diagnosis of heart disease
  • Presence of a cardiac pacemaker or artificial heart valve
  • Presence of hearing aids/prostheses
  • Hearing problems or tinnitus
  • Vision problems not corrected with lenses (such as color blindness)
  • Taking tricyclic antidepressant medications
  • Taking neuroleptic medications
  • Diagnosis of headache or migraine
  • Taking more than 3 alcoholic units in the last 24 hours
  • Taking 2 or more cups of coffee or caffeine from other sources in the last 2 hours

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Grundvidenskab
  • Tildeling: Ikke-randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Enkelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: Real motion
Participants will be asked to perform a possible motor imagery task: imagining an abduction movement of the right index finger. Each session will consist of three blocks, counterbalanced across participants. During these blocks, single TMS pulses will be delivered at different phases of the EEG oscillation: positive peak, negative peak, and random phase, the latter serving as the control condition.
Andet: Behavioral Treatment
Imagining an abduction movement of the right index finger
Andet: Behavioral Treatment
Imagining the right index finger remaining still, which will serve as the control condition
Sham-komparator: No motion
Participants will be asked to perform a possible motor imagery task: imagining the right index finger remaining still, which will serve as the control condition. Each session will consist of three blocks, counterbalanced across participants. During these blocks, single TMS pulses will be delivered at different phases of the EEG oscillation: positive peak, negative peak, and random phase, the latter serving as the control condition.
Andet: Behavioral Treatment
Imagining an abduction movement of the right index finger
Andet: Behavioral Treatment
Imagining the right index finger remaining still, which will serve as the control condition

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Motor-evoked potential
Tidsramme: Baseline
Motor-evoked potentials (MEPs) will be recorded from the right index-finger abductor muscle following single-pulse TMS delivered over the primary motor cortex. MEPs will be used as an index of corticospinal excitability. The main outcome measure will be the peak-to-peak MEP amplitude, calculated as the difference between the maximum and minimum EMG signal within the post-stimulation time window.
Baseline
Motor-evoked potential
Tidsramme: Immediately after the intervention
Motor-evoked potentials (MEPs) will be recorded from the right index-finger abductor muscle following single-pulse TMS delivered over the primary motor cortex. MEPs will be used as an index of corticospinal excitability. The main outcome measure will be the peak-to-peak MEP amplitude, calculated as the difference between the maximum and minimum EMG signal within the post-stimulation time window.
Immediately after the intervention
TMS-evoked potential
Tidsramme: Baseline
TMS-evoked potentials (TEPs) will be recorded using EEG following single-pulse TMS. TEPs will be used as an index of cortical responsiveness to stimulation. The main outcome measures will be the amplitude and latency of the main TEP components within predefined post-stimulation time windows.
Baseline
TMS-evoked potential
Tidsramme: Immediately after the intervention
TMS-evoked potentials (TEPs) will be recorded using EEG following single-pulse TMS. TEPs will be used as an index of cortical responsiveness to stimulation. The main outcome measures will be the amplitude and latency of the main TEP components within predefined post-stimulation time windows.
Immediately after the intervention

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

IRCCS San Camillo, Venezia, Italy

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

1. oktober 2025

Primær færdiggørelse (Faktiske)

26. februar 2026

Studieafslutning (Faktiske)

26. februar 2026

Datoer for studieregistrering

Først indsendt

3. juni 2026

Først indsendt, der opfyldte QC-kriterier

3. juni 2026

Først opslået (Faktiske)

9. juni 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

9. juni 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

3. juni 2026

Sidst verificeret

1. juni 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • 2024.01

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

INGEN

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Kliniske forsøg med Transkraniel magnetisk stimulation

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