Pharmacokinetic Response to BPI in Burns

Inclusion Criteria:

• Ages 13 years to 60 years old
• Sustained partial-thickness or full-thickness burn greater than 20% and less than 41% TBSA
• Parental consent (if subject is less than 18 years old) or individual (if subject is equal to or older than 18) signed, informed consent.
• Able to start BPI in infusion within 8 hours of burn injury.

Exclusion Criteria:

• Age > 61.
• Inhalational injury requiring mechanical ventilation.
• Partial and full thickness burns totaling > 41% total body surface area

• Cardiac dysfunction, defined as the presence of any of the following:

  1. New York Heart Class 3 or 4 heart failure.
  2. Unstable angina or acute myocardial infarction.
  3. Left ventricular ejection fraction known to be < 35%.
• Electrical or lightening induced burn injury or any injury that required cardio-pulmonary resuscitation.
• Concomitant non-burn trauma with an ISS > 9.
• Non-survivable injury secondary to burn size - patients made DNR or comfort care due to burn size.

• Patients with known causes of immunosuppression:

  1. Known history of HIV/AIDS
  2. Chronic steroid use for underlying medical conditions (equivalent to 15 mg prednisone/day).
  3. Active oncolytic therapy for known malignancy
• Known or suspected pregnancy
• Known allergy to rBPI21