Identification of Novel Targets for Regulation of Adipose Tissue Mass
Identification of Novel Targets for Regulation of Adipose Tissue Mass
| Patrocinadores |
Patrocinador principal: Gottfried Rudofsky Colaborador: Swiss Federal Institute of Technology |
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| Fuente | Heidelberg University | ||||||
| Resumen breve | The aim of this study is to understand the metabolic changes occurring in fat tissue both during controlled weight loss that lead to the improvement of type 2 diabetes and other obesity associated metabolic disorders. The novelty of the study is the analysis of preadipocytes, a poorly characterized subfraction of the adipose tissue, which provides adipocyte precursors and thereby strongly influences adipose tissue mass changes. Knowledge of pathways involved in controlling adipose tissue composition will help to design novel intervention strategies for the treatment of obesity associated metabolic disorders such as type 2 diabetes. |
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| Estado general | Completed | ||||||
| Fecha de inicio | October 2008 | ||||||
| Fecha de Terminación | August 2011 | ||||||
| Fecha de finalización primaria | August 2011 | ||||||
| Fase | N/A | ||||||
| Tipo de estudio | Interventional | ||||||
| Resultado primario |
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| Resultado secundario |
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| Inscripción | 62 | ||||||
| Condición | |||||||
| Intervención |
Tipo de intervención: Dietary Supplement Nombre de intervención: Optifast Descripción: Formula diet for twelve weeks combined with physical activity and behavioral therapy Etiqueta de grupo de brazo: Optifast |
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| Elegibilidad |
Criterios:
Inclusion Criteria: - Participants of the OPTIFAST52 program - BMI > 30 kg/m2 Exclusion Criteria: - Rejection of informed consent by the participant Género: All Edad mínima: 18 Years Edad máxima: N/A Voluntarios Saludables: No |
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| Oficial general |
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| Ubicación |
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| Ubicacion Paises |
Germany |
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| Fecha de verificación |
August 2012 |
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| Fiesta responsable |
Tipo: Sponsor-Investigator Afiliación del investigador: Heidelberg University Nombre completo del investigador: Gottfried Rudofsky Título del investigador: Oberarzt |
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| Palabras clave | |||||||
| Tiene acceso ampliado | No | ||||||
| Condición Examinar | |||||||
| Número de brazos | 1 | ||||||
| Grupo de brazo |
Etiqueta: Optifast Tipo: Other Descripción: Patients included take part at a weight reduction program over one year. |
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| Información de diseño del estudio |
Asignación: N/A Modelo de intervención: Single Group Assignment Propósito primario: Basic Science Enmascaramiento: None (Open Label) |
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