Identification of Novel Targets for Regulation of Adipose Tissue Mass

Identification of Novel Targets for Regulation of Adipose Tissue Mass


Patrocinador principal: Gottfried Rudofsky

Colaborador: Swiss Federal Institute of Technology

Fuente Heidelberg University
Resumen breve

The aim of this study is to understand the metabolic changes occurring in fat tissue both during controlled weight loss that lead to the improvement of type 2 diabetes and other obesity associated metabolic disorders. The novelty of the study is the analysis of preadipocytes, a poorly characterized subfraction of the adipose tissue, which provides adipocyte precursors and thereby strongly influences adipose tissue mass changes. Knowledge of pathways involved in controlling adipose tissue composition will help to design novel intervention strategies for the treatment of obesity associated metabolic disorders such as type 2 diabetes.

Estado general Completed
Fecha de inicio October 2008
Fecha de Terminación August 2011
Fecha de finalización primaria August 2011
Fase N/A
Tipo de estudio Interventional
Resultado primario
Medida Periodo de tiempo
number of adipocytes and preadipocytes under weight loss three years
Resultado secundario
Medida Periodo de tiempo
metabolic function of adipocytes and preadipocytes under weight loss three years
Inscripción 62

Tipo de intervención: Dietary Supplement

Nombre de intervención: Optifast

Descripción: Formula diet for twelve weeks combined with physical activity and behavioral therapy

Etiqueta de grupo de brazo: Optifast



Inclusion Criteria:

- Participants of the OPTIFAST52 program

- BMI > 30 kg/m2

Exclusion Criteria:

- Rejection of informed consent by the participant

Género: All

Edad mínima: 18 Years

Edad máxima: N/A

Voluntarios Saludables: No

Oficial general
Apellido Papel Afiliación
Christian Wolfrum, PhD Study Chair ETH Zürich
Instalaciones: University Hospital Heidelberg
Ubicacion Paises


Fecha de verificación

August 2012

Fiesta responsable

Tipo: Sponsor-Investigator

Afiliación del investigador: Heidelberg University

Nombre completo del investigador: Gottfried Rudofsky

Título del investigador: Oberarzt

Palabras clave
Tiene acceso ampliado No
Condición Examinar
Número de brazos 1
Grupo de brazo

Etiqueta: Optifast

Tipo: Other

Descripción: Patients included take part at a weight reduction program over one year.

Información de diseño del estudio

Asignación: N/A

Modelo de intervención: Single Group Assignment

Propósito primario: Basic Science

Enmascaramiento: None (Open Label)