Neural Bases of the Check Process (Check)
Effective exploration of the environment, check for information to improve one's own performance, are fundamental abilities of human cognition. These abilities are dependent on the process of cognitive control.
However, they are clearly impaired and uncontrollable in certain behavioral disorders such as obsessive-compulsive disorder (OCD). Compulsive checks of these patients, spontaneously associated with a feeling of intense uncertainty, suggest disturbances of evaluative and metacognitive functions. However, no biological observations have yet been able to feed these hypotheses.
The evaluation of decisions and actions involves the middle cingulate cortex (MCC) (which belongs to a cortico-subcortical network structurally and functionally altered in OCD patients). Cingulotomy has long been used as a therapy in severe OCD, with However, the precise part of the cingulate cortex that contributes to check (and its pathological forms) remains to be discovered.
The purpose of this research campaign is to determine, through functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) in healthy human subjects:
- the location and role of the MCC region involved in normal check decision processes,
- determine the identity of the entire network involved
調査の概要
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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Bron、フランス
- Inserm U1208
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- adults age range 20-45 years
- being able to provide a written consent form
- having a social insurance
- have a normal vision (with or without corrections)
- Right-handed
Exclusion Criteria:
- Subjects with MRI contraindications (e.g. pacemaker, claustrophobia, metal in the body, etc…).
- Pregnant subjects
- Subjects with neurological history
- Subjects must be willing to be advise in case of discovery of brain abnormality.
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：基礎科学
- 割り当て：なし
- 介入モデル：単一グループの割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：fMRI and EEG study
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fMRI and EEG study
|
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Measuring changes in brain activity in regions of interest when performing cognitive tasks.
時間枠：through study completion, an average of 3 years
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Behavior: Measurement of reaction times of correct answer during cognitive task. fMRI and EEG: Brain activity signal, |
through study completion, an average of 3 years
|
|
Measuring changes in brain activity in regions of interest when performing cognitive tasks.
時間枠：through study completion, an average of 3 years
|
Behavior: Measurement of % of correct answer during cognitive task.
|
through study completion, an average of 3 years
|
|
Measuring changes in brain activity in regions of interest when performing cognitive tasks.
時間枠：through study completion, an average of 3 years
|
- Measurement of the amplitude of the BOLD signal change in MRI according to the different cognitive tasks in the different regions of interest. Measurement of resting GABA and Glutamate concentrations in the different regions of interest. Measurement of the amplitude of the change of the electrical signal in EEG according to the different cognitive tasks in the different regions of interest. |
through study completion, an average of 3 years
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Calculation of the correlations in the regions of interest of the individual values of the Blood Oxygen Level Dependent (BOLD) signal with the data of the concentration of Acide γ-aminobutyrique (GABA)
時間枠：through study completion, an average of 3 years
|
calculate with the bold signal (spectroscopy)
|
through study completion, an average of 3 years
|
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Calculation of the correlations in the regions of interest of the individual values of the Blood Oxygen Level Dependent (BOLD) signal with the data of the amplitude of the electrical signal (EEG)
時間枠：through study completion, an average of 3 years
|
through study completion, an average of 3 years
|
協力者と研究者
スポンサー
捜査官
- 主任研究者：Emmanuel Procyk、Inserm U1208
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
その他の研究ID番号
- 69HCL17_0143
- 2018-A00405-50 (その他の識別子：ID-RCB)
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
米国FDA規制機器製品の研究
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
fMRI and EEG studyの臨床試験
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Federal Research Center of Fundamental and Translational...完了
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Rennes University Hospitalわからない
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University of BirminghamUniversity Hospital Birmingham; Birmingham and Solihull Mental Health NHS Foundation Trust完了
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Medical University of South CarolinaColumbia University; University of Wisconsin, Madison; University of Oklahoma; Defense Advanced...募集
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Hospices Civils de LyonUniversity of Konstanz完了
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University of MichiganNational Center for Complementary and Integrative Health (NCCIH)募集
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CSEM Centre Suisse d'Electronique et de Microtechnique...Institute for Diagnostic and Interventional Neuroradiology, Inselspital募集てんかん | 健康 | 精神病 | 本態性振戦スイス