Cognition and Neuroplasticity Sedentary Adults After 8 Weeks of Aerobic Exercise

Inclusion Criteria:

• age ≥ 55years
• no clinically detectable cognitive impairment (MoCA score ≥ 24 and Clinical Dementia Rating (CDR) score of 0)
• low activity level (individuals who do not engage in regular exercise, or currently exercise once a week or less)
• primary language is English

Exclusion Criteria:

• any unstable medical condition (i.e.: uncontrolled hypertension or uncontrolled diabetes)
• medical contraindication to physical exercise
• contraindication to TMS Neuroplasticity testing, as per the TMS Safety Guidelines.
• History of fainting spells of unknown or undetermined etiology that might constitute seizures
• History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or family history of treatment resistant epilepsy
• Any current history of a psychiatric illness
• No medication is an absolute exclusion from TMS. Medications will be reviewed by the Principal Investigator and a decision about inclusion will be made based on the following:
• The subject's past medical history, drug dose, history of recent medication changes or duration of treatment, and combination with other Central Nervous System (CNS) active drugs.
• The published TMS guidelines review medications to be considered with TMS.
• Any metal in the brain, skull or elsewhere unless approved by the responsible MD
• Any medical devices (i.e. Cardiac pacemaker, deep brain stimulator, medication infusion pump, cochlear implant, vagal nerve stimulator)
• Intracranial lesion
• Substance abuse or dependence within the past six months
• Pregnant women
• Vulnerable populations such as prisoner's
• People unable to consent themselves
• Subjects who, in the Investigator's opinion might not be suitable for the study