"Neighborhood Disadvantage, Sleep and Vascular Health" (NDSVH)
"Neighborhood Disadvantage, Sleep, and Vascular Health: Racial Disparities in Cardiometabolic Health and Blood Pressure"
Study Overview
Status
Status
Conditions
Conditions
Detailed Description
Study Type
Study Type
Enrollment (Actual)
Enrollment
Contacts and Locations
Study Locations
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Alabama
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Auburn, Alabama, United States, 36949
- Kinesiology Building
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Participation Criteria
Eligibility Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
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Exclusion Criteria:
- Systolic blood pressure greater than 150 mmHg
- Diastolic blood pressure greater than 90 mmHg
- Body mass index above 35 kg/m^2
- History of cardiovascular disease
- Recent (one year) history of cancer
- History of metabolic disease (e.g. type 2 diabetes)
Study Plan
How is the study designed?
Design Details
Number of groups / cohorts
Cohorts and Interventions
Group / CohortGroup / Cohort |
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College Students
The cohort consists of Black and White college students at a university in a southeastern state in America.
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What is the study measuring?
Primary Outcome Measures
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
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Flow-mediated dilation (FMD)
Time Frame: Baseline racial comparison
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Flow-mediated vasodilation will be assessed using continuous measures of brachial artery diameter and velocity via duplex Doppler ultrasound (Hitachi Arietta 70).
The brachial artery will be imaged in the longitudinal plane proximal to the medial epicondyle using a high-frequency (6-12 MHz) linear-array probe.
The ultrasound probe will be stabilized using a custom-built clamp.
Shear rate (sec-1) will be calculated as [(blood flow velocity (cm*s-1) *4)/blood vessel diameter (mm)] The image will be recorded throughout a 60-s baseline, a 300-s ischemic stimulus (250 mmHg), and 180 seconds post deflation.
FMD will be expressed as % dilation (final diameter-baseline diameter/baseline diameter x 100) and also normalized to the shear stimulus.
Allometric scaling will be used if appropriate, including if there are baseline differences in artery diameter by race or condition.
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Baseline racial comparison
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Pulse wave velocity (arterial stiffness)
Time Frame: Baseline racial comparison
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The investigators will use the SphygmoCor XCEL system to assess pulse wave velocity (PWV).
A high-fidelity strain-gauge transducer is used to obtain the pressure waveform at the carotid pulse.
Distances from the carotid artery sampling site to the femoral artery (upper leg instrumented with a thigh cuff for oscillometric sphygmomanometry), and from the carotid artery to the suprasternal notch will be recorded.PWV will be expressed as cm/s.
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Baseline racial comparison
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Pulse wave analysis (arterial stiffness)
Time Frame: Baseline racial comparison
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The investigators will use the SphygmoCor XCEL system to assess pulse wave analysis (PWA) using an upper arm blood pressure cuff.
PWA will be expressed as % (calculated as augmentation pressure divided by the pulse pressure).
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Baseline racial comparison
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24-hour ambulatory blood pressure
Time Frame: Baseline racial comparison
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Participants will wear an Oscar2 (with SphygmoCor) ambulatory blood pressure monitor on their upper arm for up to 24-hours preceding their study visit to measure systolic and diastolic blood pressure.
The purpose of the ambulatory blood pressure monitoring is to determine blood pressure regulation over an entire day.
This blood pressure monitor will be set to automatically take blood pressure every 20 minutes.
The monitor records and saves each blood pressure measurement automatically.
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Baseline racial comparison
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Blood pressure reactivity
Time Frame: Baseline racial comparison
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The investigators will measure systolic and diastolic pressure using photoplethysmography at the finger.
Systolic and diastolic blood pressure will be assessed at rest and during handgrip exercise.
Blood pressure reactivity will be expressed as a change in pressure (mmHg) from baseline to a predetermined time during the stressor (e.g., minute one average and minute two average).
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Baseline racial comparison
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Objective sleep duration and quality
Time Frame: Baseline racial comparison
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Philips actiwatch spectrum will be used to quantify sleep duration.
Participants will wear the watch units for 7 days.
The investigators will cross-check actigraphy wear times with a sleep diary.
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Baseline racial comparison
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Subjective sleep quality
Time Frame: Baseline racial comparison
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The investigators will use the Pittsburgh Sleep Quality Index (PSQI) to asses sleep duration and perceived sleep quality reflective of the one month period leading into the study.
The PSQI global score has a possible range of 0-21 points.
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Baseline racial comparison
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Secondary Outcome Measures
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
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Circulating reactive oxygen species
Time Frame: Baseline racial comparison
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The investigators will use electron paramagnetic resonance to measure reactive oxygen species (spectra units) in whole blood samples treated with a spin probe.
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Baseline racial comparison
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Blood biomarkers of nitric oxide bioavailability
Time Frame: Baseline racial comparison
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The investigators will measure nitric oxide metabolites (nitrate and nitrite nanomolar concentration) using chemiluminescence
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Baseline racial comparison
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Physical activity
Time Frame: Baseline racial comparison
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Participants will wear an ActiGraph GT3X accelerometer for seven days to objectively quantify steps per day and metabolic equivalents per day.
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Baseline racial comparison
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Mental health - social anxiety
Time Frame: Baseline racial comparison
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The investigators will administer the Liebowitz Social Anxiety Scale.
The scale starts at 0 (none) and ends at 3 (severe) for 24 questions related to anxiety and avoidance, and a cumulative score is calculated.
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Baseline racial comparison
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Mental health - depression
Time Frame: Baseline racial comparison
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The investigators will administer the Beck's Depression Inventory.
The scale starts at 0 and ends at 3 for 21 questions related to depression.
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Baseline racial comparison
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Neighborhood disadvantage
Time Frame: Baseline racial comparison
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The investigators will ask participants to identify their home addresses with investigator assistance and Google maps and potential assistance from their guardians or parents during early- and mid-childhood and adolescence.
The investigators will use the participant's address and census tract information to determine measures of neighborhood quality such as median income, crime rates, and median education level.
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Baseline racial comparison
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Habitual dietary intake
Time Frame: Baseline racial comparison
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The investigators will instruct participants to complete a diet log for 5 days which will be operationalized with Nutrition Data System for Research (NDSR).
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Baseline racial comparison
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Other Outcome Measures
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
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24-hour urine electrolytes
Time Frame: Baseline racial comparison
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The investigators will use an electrolyte analyzer to assess sodium, potassium, and chloride concentration.
The investigators will use urine volume and electrolyte concentration to determine 24-hour electrolyte excretion
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Baseline racial comparison
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Collaborators and Investigators
Sponsor
Sponsor
Investigators
Investigators
- Principal Investigator: Austin T Robinson, PhD, Auburn University
Publications and helpful links
General Publications
- Jeong S, Linder BA, Barnett AM, Tharpe MA, Hutchison ZJ, Culver MN, Sanchez SO, Nichols OI, Grosicki GJ, Bunsawat K, Nasci VL, Gohar EY, Fuller-Rowell TE, Robinson AT. Interplay of Race and Neighborhood Deprivation on Resting and Ambulatory Blood Pressure in Young Adults. Am J Physiol Heart Circ Physiol. 2024 Jul 12. doi: 10.1152/ajpheart.00726.2023. Online ahead of print.
- Robinson AT, Linder BA, Barnett AM, Jeong S, Sanchez SO, Nichols OI, McIntosh MC, Hutchison ZJ, Tharpe MA, Watso JC, Gutierrez OM, Fuller-Rowell TE. Cross-sectional analysis of racial differences in hydration and neighborhood deprivation in young adults. Am J Clin Nutr. 2023 Oct;118(4):822-833. doi: 10.1016/j.ajcnut.2023.08.005. Epub 2023 Aug 22.
Study record dates
Study Major Dates
Study Start (Actual)
Study Start
Primary Completion (Actual)
Primary Completion
Study Completion (Actual)
Study Completion
Study Registration Dates
First Submitted
First Submitted
First Submitted That Met QC Criteria
First Submitted That Met QC Criteria
First Posted (Actual)
First Posted
Study Record Updates
Last Update Posted (Actual)
Last Update Posted
Last Update Submitted That Met QC Criteria
Last Update Submitted That Met QC Criteria
Last Verified
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
Other Study ID Numbers
- AU IRB #20-262 FB
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
IPD Sharing Time Frame
IPD Sharing Access Criteria
IPD Sharing Supporting Information Type
- STUDY_PROTOCOL
- SAP
- ICF
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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