- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00003466
Temozolomide in Treating Patients With Progressive Low-Grade Glioma
Phase II Treatment of Adults and Children With Progressive Low Grade Gliomas With Temodal
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: This phase II trial is studying how well temozolomide works in treating patients with progressive low-grade glioma.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
OBJECTIVES:
- Assess the response rate in patients with progressive low-grade gliomas treated with temozolomide.
- Determine the activity of this drug, in terms of stabilizing growth of progressive low-grade gliomas, in adult patients.
OUTLINE: Patients are stratified by disease type (pilocytic astrocytoma, mixed glioma, well-differentiated oligodendroglioma, and nonbiopsied optic pathway glioma or pontine glioma).
Patients receive temozolomide orally once daily on days 1-5. Courses repeat every 28 days. In the absence of disease progression or unacceptable toxicity, patients may continue with treatment until tumor has remained stable for 12 courses.
Patients are followed every 8-12 weeks for 2 years.
PROJECTED ACCRUAL: A total of 36-100 patients (9-25 per stratum) will be accrued for this study within 3 years.
Study Type
Enrollment (Anticipated)
Phase
- Phase 2
Contacts and Locations
Study Locations
-
-
North Carolina
-
Durham, North Carolina, United States, 27710
- Duke Comprehensive Cancer Center
-
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Pennsylvania
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Philadelphia, Pennsylvania, United States, 19104-4318
- Children's Hospital of Philadelphia
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
DISEASE CHARACTERISTICS:
Histologically confirmed progressive, primary, intracranial, supratentorial, low-grade glioma including:
- Astrocytoma
- Oligodendroglioma
- Mixed glioma
- Optic pathway glioma*
- Pontine glioma* NOTE: *Biopsy not required
Patients with optic pathway glioma must also meet the following criteria:
- Progressive loss of vision as defined by doubling of octaves
- Visual acuity loss not explained by other causes
- Increase in proptosis of greater than 3 mm
- Increase in diameter of optic nerve of at least 2 mm on neuroimaging
- Increase in distribution of tumor involving optic tracts or optic radiations as indicated by CT scan or MRI
PATIENT CHARACTERISTICS:
Age:
- 4 and over
Performance status:
- Karnofsky 70-100%
Life expectancy:
- More than 12 weeks
Hematopoietic:
- Absolute neutrophil count at least 1,500/mm^3
- Platelet count at least 100,000/mm^3
- Hemoglobin at least 10 g/dL
Hepatic:
- Bilirubin less than 1.5 times upper limit of normal (ULN)
- SGOT and SGPT less than 2.5 times ULN
- Alkaline phosphatase less than 2 times ULN
Renal:
- Creatinine less than 1.5 times ULN
- BUN less than 1.5 times ULN
Other:
- Must be neurologically stable
- No systemic disease
- No acute infection requiring IV antibiotics
- No frequent vomiting
- No other medical condition that would interfere with oral medication (e.g., partial bowel obstruction)
No other prior or concurrent malignancies except:
- Surgically cured carcinoma in situ of the cervix
- Basal or squamous cell skin cancer
- HIV negative
- No AIDS-related illness
- Not pregnant or nursing
- Fertile patients must use effective contraception
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- No concurrent biologic therapy (growth factors or epoetin alfa)
Chemotherapy:
- At least 6 weeks since prior chemotherapy unless evidence of disease progression
- No other concurrent chemotherapy
Endocrine therapy:
- Not specified
Radiotherapy:
- At least 6 weeks since prior radiotherapy unless evidence of disease progression
- No concurrent radiotherapy
Surgery:
- At least 3 weeks since prior surgery unless evidence of disease progression
- Recovered from all prior surgery
Other:
- No other concurrent investigational drugs
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
---|
Response rate
|
Activity of temozolomide
|
Collaborators and Investigators
Sponsor
Collaborators
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
- untreated childhood brain stem glioma
- recurrent adult brain tumor
- adult brain stem glioma
- adult diffuse astrocytoma
- adult oligodendroglioma
- adult subependymoma
- adult mixed glioma
- adult pilocytic astrocytoma
- recurrent childhood cerebral astrocytoma
- recurrent childhood brain stem glioma
- recurrent childhood visual pathway and hypothalamic glioma
- untreated childhood visual pathway and hypothalamic glioma
- childhood mixed glioma
Additional Relevant MeSH Terms
- Nervous System Diseases
- Neoplasms by Histologic Type
- Neoplasms
- Neoplasms by Site
- Neoplasms, Glandular and Epithelial
- Neoplasms, Neuroepithelial
- Neuroectodermal Tumors
- Neoplasms, Germ Cell and Embryonal
- Neoplasms, Nerve Tissue
- Glioma
- Nervous System Neoplasms
- Central Nervous System Neoplasms
- Molecular Mechanisms of Pharmacological Action
- Antineoplastic Agents
- Antineoplastic Agents, Alkylating
- Alkylating Agents
- Temozolomide
Other Study ID Numbers
- 1703 (CDR0000066502)
- DUMC-1703-04-12R7
- DUMC-000693-01-3R1
- DUMC-1703-01-94R
- DUMC-1502-97-10
- DUMC-1569-98-10R1
- DUMC-97125
- NCI-G98-1469
- DUMC-1703-02-9R5
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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