AAB-001 (Bapineuzumab) Open-Label, Long-Term Extension Study in Patients With Mild to Moderate Alzheimer's Disease

October 30, 2013 updated by: JANSSEN Alzheimer Immunotherapy Research & Development, LLC

A Phase II, Multicenter, Open-Label, Long-Term Treatment Study to Determine the Safety, Tolerability, and Efficacy of Bapineuzumab (AAB-001) in Patients With Alzheimer's Disease Who Participated in Study AAB-001-201 or AAB-001-102

This is a multicenter, open-label, long-term extension study in male and female patients with mild to moderate Alzheimer's Disease (AD) who must have completed one of the following studies: AAB-001-201 or AAB-001-102. All patients enrolled in Study AAB-001-251 will receive infusions of AAB-001 (bapineuzumab), including patients randomized to placebo in Study 201 and 102. Approximately 30 study sites in the US will be involved. Each patient's participation may vary from 3 months up to 84 months depending on the date of enrollment in this study.

AAB-001 (bapineuzumab) is a humanized monoclonal antibody, which binds to and potentially clears beta amyloid peptide, and is designed to provide antibodies to beta amyloid directly to the patient.

Study Overview

Status

Terminated

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

194

Phase

  • Phase 2

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Arizona
      • Peoria, Arizona, United States, 85381
        • Janssen AI Investigational Site
      • Sun City, Arizona, United States, 85351
        • Janssen AI Investigational Site
    • California
      • Encino, California, United States, 91316
        • Janssen AI Investigational Site
      • Irvine, California, United States, 92697
        • Janssen AI Investigational Site
      • La Jolla, California, United States, 92037
        • Janssen AI Investigational Site
      • Los Alamitos, California, United States, 90720
        • Janssen AI Investigational Site
      • Sacramento, California, United States, 95817
        • Janssen AI Investigational Site
      • San Francisco, California, United States, 94143
        • Janssen AI Investigational Site
    • Connecticut
      • New Haven, Connecticut, United States, 06510
        • Janssen AI Investigational Site
    • District of Columbia
      • Washington, District of Columbia, United States, 20057
        • Janssen AI Investigational Site
    • Florida
      • Delray Beach, Florida, United States, 33445
        • Janssen AI Investigational Site
      • Jacksonville, Florida, United States, 32224
        • Janssen AI Investigational Site
    • Illinois
      • Chicago, Illinois, United States, 60612
        • Janssen AI Investigational Site
    • Indiana
      • Indianapolis, Indiana, United States, 46202
        • Janssen AI Investigational Site
    • Massachusetts
      • Boston, Massachusetts, United States, 02115
        • Janssen AI Investigational Site
    • Michigan
      • Ann Arbor, Michigan, United States, 48105
        • Janssen AI Investigational Site
    • Minnesota
      • Rochester, Minnesota, United States, 55905
        • Janssen AI Investigational Site
    • Missouri
      • St. Louis, Missouri, United States, 63108
        • Janssen AI Investigational Site
    • New Jersey
      • Eatontown, New Jersey, United States, 07724
        • Janssen AI Investigational Site
    • New York
      • New York City, New York, United States, 10032
        • Janssen AI Investigational Site
      • Rochester, New York, United States, 14620
        • Janssen AI Investigational Site
    • North Carolina
      • Durham, North Carolina, United States, 27710
        • Janssen AI Investigational Site
    • Oregon
      • Portland, Oregon, United States, 97239
        • Janssen AI Investigational Site
    • Pennsylvania
      • PIttsburgh, Pennsylvania, United States, 15213
        • Janssen AI Investigational Site
    • Rhode Island
      • Providence, Rhode Island, United States, 02906
        • Janssen AI Investigational Site
    • Texas
      • Dallas, Texas, United States, 75390
        • Janssen AI Investigational Site
      • Houstan, Texas, United States, 77030
        • Janssen AI Investigational Site
    • Vermont
      • Bennington, Vermont, United States, 05201
        • Janssen AI Investigational Site
    • Washington
      • Seattle, Washington, United States, 98108
        • Janssen AI Investigational Site

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • ADULT
  • OLDER_ADULT
  • CHILD

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

A subject must meet ALL of the following criteria to be considered for enrollment into this study:

  1. Signed and dated written informed consent obtained from the subject and/or the subject's caregiver in accordance with the local regulations.
  2. Subjects must have completed Study 201 Visit 22 (Week 78), or Study 102 Visit 11 (Week 16).
  3. Magnetic resonance imaging scan of sufficient quality for the Radiologist to evaluate subject safety from Study 201 Visit 21 (Week 71), or Study 251 Screening Visit for subjects from Study 102.
  4. Lives at home with appropriate caregiver capable of accompanying the subject on all clinic visits, or community dwelling with caregiver capable of accompanying the subject on all clinic visits and visiting with the subject approximately five times per week for the duration of the study.
  5. In the opinion of the investigator, the subject and the caregiver will be compliant.

Exclusion Criteria:

ANY one of the following will exclude a subject from being enrolled into the study:

  1. Significant neurological disease other than AD that may affect cognition.
  2. Screening visit brain MRI scan (ie, Study 201 Visit 21 (Week 71), or for Study 102, the Study 251 Screening Visit) indicative of any other significant abnormality including but not limited to multiple microhemorrhages or evidence of a single prior hemorrhage >1 cm3, multiple lacunar infarcts or evidence of a single prior infarct >1 cm3, evidence of a cerebral contusion, encephalomalacia, arachnoid cysts, or brain tumors (eg, meningioma) unless approved by the medical monitor.
  3. Current presence of a clinically significant major psychiatric disorder according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM IV) or any clinically significant symptom that could affect the subject's ability to participate in the study.
  4. Current clinically significant systemic illness that is likely to result in deterioration of the subject's condition or affect the subject's safety during the study.
  5. History of clinically evident stroke or history of clinically significant carotid or vertebrobasilar stenosis or plaque.
  6. History of seizures, excluding febrile seizures in childhood.
  7. Weight greater than 120 kg (264 lbs).
  8. History or evidence of any clinically significant autoimmune disease or disorder of the immune system.
  9. Clinically significant infection within the last 30 days (eg, chronic persistent or acute infection).
  10. Treatment with immunosuppressive medications (eg, systemic corticosteroids) within the last 90 days (topical and nasal corticosteroids and inhaled corticosteroids for asthma are permitted) or chemotherapeutic agents for malignancy within the last three years.
  11. Myocardial infarction within the last two years.
  12. History of cancer within the last five years, with the exception of basal cell carcinoma, and nonmetastatic squamous cell carcinoma of the skin.
  13. Other clinically significant abnormality on screening (ie, Study 201 Visit 22 [Week 78], or Study 102 Visit 11 [Week 16]) physical, neurological, laboratory, or ECG examination (eg, atrial fibrillation) that could compromise the study or be detrimental to the subject.
  14. Hemoglobin less than 11 g/dL at screening (ie, Study 201 Visit 22 [Week 78], or Study 102 Visit 11 [Week16]).
  15. Smoking more than 20 cigarettes per day.
  16. History of alcohol or drug dependence or abuse within the last two years.
  17. Current use of anticonvulsant for seizures, anti-Parkinson's, anticoagulant (excluding the use of aspirin 325 mg/day or less), or narcotic medications.
  18. Any prior experimental treatment with AN1792 or other experimental immunotherapeutic or vaccine for AD (other than bapineuzumab).
  19. Any known hypersensitivity to any of the excipients contained in the study drug formulation.
  20. Women of childbearing potential.
  21. Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, cerebrospinal fluid (CSF) shunts, metal fragments or foreign objects in the eyes, skin, or body that would contraindicate a brain MRI scan (unless otherwise approved by the Sponsor and/or its designees).

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Allocation: NON_RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: NONE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
ACTIVE_COMPARATOR: 1
0.15 mg/kg active bapineuzumab
Drug: Bapineuzumab (AAB-001)
IV q13w
Other Names:
  • AAB-001
ACTIVE_COMPARATOR: 2
0.5 mg/kg active bapineuzumab
Drug: Bapineuzumab (AAB-001)
IV q13w
Other Names:
  • AAB-001
ACTIVE_COMPARATOR: 3
1.0 mg/kg active bapineuzmab
Drug: Bapineuzumab (AAB-001)
IV q13w
Other Names:
  • AAB-001

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
To assess the safety and tolerability of long-term treatment of bapineuzumab in subjects with AD.
Time Frame: 3-84 months
  • The incidence and severity of treatment-emergent adverse events (TEAEs);
  • Clinically important changes in safety assessment results (including, as appropriate, vital signs, weight, clinical laboratory tests, electrocardiograms [ECGs], brain magnetic resonance imaging [MRIs], physical and neurological examinations, and infusion site assessments).
3-84 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
To evaluate the efficacy of long-term treatment of bapineuzumab in subjects with AD.
Time Frame: 3-84 months

Change from Visit 2 (Pre-Day 1) and Visit 22 (Week 78) of Study AAB-001-201 for the following scales:

  • Alzheimer's Disease Assessment Scale - Cognitive subscale (ADAS-Cog)
  • Disability Assessment for Dementia (DAD)
  • Mini Mental State Examination (MMSE)

Change from Study AAB-001-251Visit 1 (Day 1) for the following scales:

  • Dependence Scale
  • Resource Utilization in Dementia (RUD) Lite

Change from Study 251 Screening Visit for the following scales for subjects entering from Study AAB-001-102 (US):

  • ADAS-Cog
  • DAD
  • MMSE
3-84 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

JANSSEN Alzheimer Immunotherapy Research & Development, LLC

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

December 1, 2006

Primary Completion (ACTUAL)

September 1, 2012

Study Completion (ACTUAL)

September 1, 2012

Study Registration Dates

First Submitted

January 11, 2008

First Submitted That Met QC Criteria

January 22, 2008

First Posted (ESTIMATE)

February 4, 2008

Study Record Updates

Last Update Posted (ESTIMATE)

November 25, 2013

Last Update Submitted That Met QC Criteria

October 30, 2013

Last Verified

August 1, 2012

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • AAB-001-251

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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