Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm

Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm Determined by Dynamic Analysis of Exhaled Breath Condensate.

This research is being conducted to help us better understand what causes exercise induced asthma. The investigators hypothesize that two types of chemicals, cysteinyl leukotrienes and adenosine, play an important role. The investigators will be measuring these chemicals in the exhaled breath of volunteers with exercise induced asthma as they undergo a test to mimic exercise induced asthma. The investigators will determine how the levels of these chemicals change in association with how lung function changes before, during and after an episode of exercise induced asthma.

Study Overview

• Status: Completed
• Conditions: Asthma, Exercise Induced
• Intervention / Treatment: Procedure: Hyperpnea challenge

• Study Type: Observational
• Enrollment (Actual): 8

Contacts and Locations

Study Locations

• United States
  • Vermont
    • Colchester, Vermont, United States, 05446
      • Vermont Lung Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 12 years to 75 years (ADULT, OLDER_ADULT, CHILD)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Asthmatics with exercise induced bronchospasm

Description

Inclusion Criteria:

• Physician diagnosed asthma
• Age 12-75 yrs
• FEV1 > 70% predicted
• HIB response > 10 %
• No smoking last 6 mo and < 10 pack yrs
• No URI last 4 weeks
• No asthma exacerbation last 4 weks
• Able to withhold SABA > 8 hrs and LABA > 24 hrs

Exclusion Criteria:

• Other lung disease
• Cardiac disease or other condition that would preclude safe participation, on theophylline or leukotriene modifiers

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Asthmatics; Asthmatics with exercise induced bronchospasm	Procedure: Hyperpnea challenge; 5 minutes of dry air hyperpnea to induce bronchospasm

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Change in level of cystLTs and adenosine	Before and after hyperpnea challenge

Secondary Outcome Measures

Outcome Measure	Time Frame
Change in pH of EBC and change in pulmonary function	Before and after hyperpnea challenge

Collaborators and Investigators

• Sponsor: University of Vermont
• Investigators: Principal Investigator: David A. Kaminsky, MD, University of Vermont

Study record dates

Study Major Dates

• Study Start: October 1, 2007
• Primary Completion (ACTUAL): March 1, 2009
• Study Completion (ACTUAL): July 1, 2009

Study Registration Dates

• First Submitted: July 2, 2008
• First Submitted That Met QC Criteria: July 3, 2008
• First Posted (ESTIMATE): July 4, 2008

Study Record Updates

• Last Update Posted (ESTIMATE): October 31, 2016
• Last Update Submitted That Met QC Criteria: October 27, 2016
• Last Verified: October 1, 2016

More Information

Terms related to this study

• Keywords: Asthma; adenosine; exhaled breath condensate; Exercise induced bronchospasm; Hyperpnea induced bronchospasm; leukotrienes
• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Immune System Diseases; Hypersensitivity, Immediate; Bronchial Diseases; Respiratory Hypersensitivity; Hypersensitivity; Asthma; Bronchial Spasm; Asthma, Exercise-Induced
• Other Study ID Numbers: CHRMS 08-023; Merck IISP 32710