- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00890916
Hand Function for Tetraplegia
May 21, 2021 updated by: VA Office of Research and Development
Hand Function for Tetraplegia Using a Wireless Neuroprosthesis
The purpose of this study is to evaluate the effectiveness of an implanted stimulator for providing hand function to individuals with cervical level spinal cord injury.
The device stimulates the paralyzed muscles of the hand and forearm.
The user of the device controls the stimulation by moving muscles that are not paralyzed, such as a wrist or neck muscle.
The ability of the user to pick up and move objects, as well as perform various activities such as eating, drinking, and writing.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
The overall object of this research is to provide restored functional abilities to individuals with cervical-level spinal cord injury through the use of an advanced wireless myoelectrically controlled battery-powered implanted neuroprosthetic system known as the "FIRSTHAND" System.
This restored function can enable the individual to achieve greater independence in activities of daily living and an improved quality of life.
Electrical stimulation of paralyzed muscles will be used to generate functional movements.
The movements will be controlled using myoelectric signals generated from muscles under the subject's voluntary control.
The specific hypotheses of this study are: 1) at least 75% of all subjects will be able to manipulate at least one more object in the Grasp-Release Test when using the advanced neuroprosthesis compared to without the neuroprosthesis.
2) At least 75% of all subjects will demonstrate an increased level of independence in at least one functional activity when using the advanced neuroprosthesis.
3) At least 75% of all subjects will demonstrate an average neuroprosthesis usage of at least three days/week.
Study Type
Interventional
Enrollment (Actual)
10
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Ohio
-
Cleveland, Ohio, United States, 44106
- Louis Stokes VA Medical Center, Cleveland, OH
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- cervical level spinal cord injury;
- complete paralysis of fingers and thumbs;
- voluntary shoulder motion;
- electrically excitable forearm and hand musculature
Exclusion Criteria:
- extreme contractures of the joints;
- skeletal immaturity;
- extensive denervation in the forearm and hand;
- poor surgical risk
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: NA
- Interventional Model: SINGLE_GROUP
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: Neuroprosthesis System
Receives implanted device for hand function.
|
Implanted neuroprosthesis with myoelectric control and electrical stimulation of multiple channels.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Grasp Release Test - Test of Functional Ability to Pick up and Move Objects
Time Frame: 6-9 weeks
|
Grasp and Release Test (GRT) - The Grasp and Release Test (GRT) [Wuolle, 1994; Smith et al., 1996; Carroll et al., 2000; Taylor et al., 2002; Mulcahey et al., 2004], developed at the Cleveland FES Center, has been utilized by multiple centers to show improvements in hand function after implantation of a neuroprosthesis and tendon transfers [Peckham, 2001].
This pick-and-place test requires the participant to unilaterally acquire, move, and release six objects varying in weight and size.
The objects are: 1) a small peg, 2) a wooden cube, 3) a small juice can, 4) a videotape, 5) a paperweight (~1000g) and a simulated fork task (spring-loaded plunger).
The number of objects that the participant can successfully manipulate are scored.
Success in manipulating each object in the GRT is defined as the ability to pick up and place the object at least once within 30 seconds.
|
6-9 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Kevin L Kilgore, PhD, Louis Stokes VA Medical Center, Cleveland, OH
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Peckham PH, Kilgore KL. Challenges and opportunities in restoring function after paralysis. IEEE Trans Biomed Eng. 2013 Mar;60(3):602-9. doi: 10.1109/TBME.2013.2245128. Epub 2013 Mar 7.
- Kilgore KL, Bryden A, Keith MW, Hoyen HA, Hart RL, Nemunaitis GA, Peckham PH. Evolution of Neuroprosthetic Approaches to Restoration of Upper Extremity Function in Spinal Cord Injury. Top Spinal Cord Inj Rehabil. 2018 Summer;24(3):252-264. doi: 10.1310/sci2403-252.
- Kilgore KL, Hoyen HA, Bryden AM, Hart RL, Keith MW, Peckham PH. An implanted upper-extremity neuroprosthesis using myoelectric control. J Hand Surg Am. 2008 Apr;33(4):539-50. doi: 10.1016/j.jhsa.2008.01.007.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
January 1, 2012
Primary Completion (ACTUAL)
November 1, 2015
Study Completion (ACTUAL)
May 1, 2021
Study Registration Dates
First Submitted
April 27, 2009
First Submitted That Met QC Criteria
April 29, 2009
First Posted (ESTIMATE)
April 30, 2009
Study Record Updates
Last Update Posted (ACTUAL)
June 9, 2021
Last Update Submitted That Met QC Criteria
May 21, 2021
Last Verified
May 1, 2021
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- A6027-R
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
Yes
product manufactured in and exported from the U.S.
Yes
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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