- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00953095
Social and Communication Outcomes for Young Children With Autism
Optimizing Social and Communication Outcomes for Young Children With Autism
The goal of this project is to test an intervention program for caregivers and their young children with autism that is focused on improving social communication. This study specifically targets underserved populations, specifically children from low SES and racial/ethnic minority families. Participants will include 40 children (aged 24 months to 60 months) and their caregivers who will be randomized (as if by flipping a coin) to one of the two treatments: Parent education sessions for two hours a week for 12 weeks or parent-child intervention sessions with the child for one hour, twice a week for 12 weeks. Young children with autism have difficulty with engaging in joint attention with others (e.g. pointing, showing. Joint attention skills are important to later development of language. Therefore, targeting this problem in young children may result in better language outcomes for these children.
In order to examine the effects of the interventions, all participants will be complete cognitive, language, communication and play-based assessments prior to treatment, at the end of the first 12 weeks of the intervention, and post-treatment immediately following the intervention (approximately 2.5 to 3 hours each).
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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California
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Los Angeles, California, United States, 90095
- University of California, Los Angles
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Florida
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Tallahassee, Florida, United States, 32306
- Florida State University
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Maryland
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Baltimore, Maryland, United States, 21211
- Kennedy Krieger Institute
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Michigan
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Ann Arbor, Michigan, United States, 48109
- University of Michigan
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Washington
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Seattle, Washington, United States, 98195
- University of Washington
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Children must be between 24 months and 60 months at entry into the study
- Children must have a clinical diagnosis of autism or PDD-NOS, and/or meet criteria on the ADOS for ASD or autism
- Children must have an age equivalent of 12 months or greater for non-verbal ability based on the Mullen Visual Reception and Fine Motor scales
- Caregiver and child must be available for all assessments
- Children must be able to walk independently
- Parents must be between the ages of 16 and 50 years old
- Family should be currently underserved (inability to obtain services for their child) and have limited family resources
Exclusion Criteria:
- Children must not have a seizure disorder
- Children must not have associated sensory (uncorrected hearing loss greater than 20 db or vision loss) or physical disorders that restrict mobility (e.g., cerebral palsy)
- Children must not have sustained a head injury
- Children's diagnosis of autism spectrum disorder must not be comorbid with other medical syndromes (e.g., Tuberose Sclerosis, Neurofibromatosis, Down syndrome, fragile X) or diseases
- Children must not be in foster care
- English must be the primary language spoken at home
- Parents must not have a psychiatric diagnosis or a diagnosis of mental retardation
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Caregiver Mediated Model (CMM)
focuses on joint attention/engagement intervention using an established evidence based treatment (Kasari et al., 2006).
It involves meeting the parent and child in their home for one hour, twice a week for 12 weeks.
In this intervention, the parent-child pair meet with the interventionist (as opposed to the group training in the CEM condition).
Parents will be specifically taught techniques for altering the home environment and ways to enhance children's language, social, and play development.
Parents will given guided practice (input and coaching from the interventionist) as they implement these techniques with their child.
|
Intervention in both conditions occurs once a week for 2 hours.
Participants will be randomized to 1 of 2 interventions : (1) Caregiver Mediated Model (CMM):focuses on joint attention/engagement and involves individual meetings with the parents and children at their homes.
Parents will be specifically taught techniques for altering the home environment and ways to enhance children's language, social, and play development.
Parents will given guided practice (input/ coaching from the interventionist) as they implement these techniques with their child.
(2) Caregiver Education Model (CEM): focuses on teaching parents information about autism, behavior modification, and community services.
Parents will receive information on child development each week, and will be able to ask questions and discuss the information.
Parents meet in a group (without their children) in a community-based setting to receive the intervention.
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Experimental: Caregiver Education Model (CEM)
focuses on teaching parents information about autism, behavior modification, and community services using a manualized approach (Brereton & Tonge, 2005).
Parents will receive information on child development each week, and will be able to ask questions and discuss the information vis-à-vis their own child.
This intervention is manualized (Brereton & Tonge 2005).
In the CEM condition, parents meet in a group (without their children) in a community-based setting to receive the intervention.
Intervention sessions occur once a week for 2 hours.
|
Intervention in both conditions occurs once a week for 2 hours.
Participants will be randomized to 1 of 2 interventions : (1) Caregiver Mediated Model (CMM):focuses on joint attention/engagement and involves individual meetings with the parents and children at their homes.
Parents will be specifically taught techniques for altering the home environment and ways to enhance children's language, social, and play development.
Parents will given guided practice (input/ coaching from the interventionist) as they implement these techniques with their child.
(2) Caregiver Education Model (CEM): focuses on teaching parents information about autism, behavior modification, and community services.
Parents will receive information on child development each week, and will be able to ask questions and discuss the information.
Parents meet in a group (without their children) in a community-based setting to receive the intervention.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
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Early Social Communication Scale
Time Frame: Before treatment, after treatment and 3 months after treatment
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Before treatment, after treatment and 3 months after treatment
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Secondary Outcome Measures
Outcome Measure |
Time Frame |
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Mullen Scales of Early Learning
Time Frame: Before treatment, after treatment, and 3 months after treatment
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Before treatment, after treatment, and 3 months after treatment
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Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Connie Kasari, Ph.D., University of California, Los Angeles
Publications and helpful links
General Publications
- Kasari C, Freeman S, Paparella T. Joint attention and symbolic play in young children with autism: a randomized controlled intervention study. J Child Psychol Psychiatry. 2006 Jun;47(6):611-20. doi: 10.1111/j.1469-7610.2005.01567.x. Erratum In: J Child Psychol Psychiatry. 2007 May;48(5):523.
- Koegel RL, Bimbela A, Schreibman L. Collateral effects of parent training on family interactions. J Autism Dev Disord. 1996 Jun;26(3):347-59. doi: 10.1007/BF02172479.
- Rutter M. Diagnosis and definition of childhood autism. J Autism Child Schizophr. 1978 Jun;8(2):139-61. doi: 10.1007/BF01537863. No abstract available.
- Tomasello M, Farrar MJ. Joint attention and early language. Child Dev. 1986 Dec;57(6):1454-63.
- Whalen C, Schreibman L. Joint attention training for children with autism using behavior modification procedures. J Child Psychol Psychiatry. 2003 Mar;44(3):456-68. doi: 10.1111/1469-7610.00135.
- Mahoney, G., Kaiser, A., Girolametto, L., MacDonald, J., Robinson, C., Safford, P., & Spiker, D. (1999). Parent education in early intervention: A call for a renewed focus. Topics in Early Childhood Special Education, 19(3), 131-140.
- Adamson LB, Bakeman R, Deckner DF, Romski M. Joint engagement and the emergence of language in children with autism and Down syndrome. J Autism Dev Disord. 2009 Jan;39(1):84-96. doi: 10.1007/s10803-008-0601-7. Epub 2008 Jun 26.
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- G09-02-016-01
- UA3MC11055 (Other Grant/Funding Number: Health Resources and Services Administration)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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